Oxford Pre-cancerous Lymphoproliferative Disorders Study

To be considered for this study, you must have been diagnosed in the last three years with one of the following conditions: high-count Monoclonal B-cell Lymphocytosis (MBL), early-stage Chronic Lymphocytic Leukaemia (CLL) that doesn't yet need treatment, certain types of Monoclonal Gammopathy of Uncertain Significance (MGUS), Waldenstrom's Macroglobulinaemia without symptoms that doesn't need treatment, or Smouldering Myeloma that also doesn't need treatment.

You must be at least 16 years old. You also need to be well enough to take part, meaning you can generally go about your daily life without too much difficulty, even if you have some symptoms. You'll need to be able to understand what the study involves and agree to take part by signing a consent form.

However, you cannot join if you are pregnant or breastfeeding, or if you have previously received chemotherapy or other treatments for these conditions. If you've been referred to a doctor for further checks on some of these conditions due to your GP's concerns or symptoms, you might still be eligible.

If you join the study, you'll be monitored for up to five years. During this time, you'll have regular visits where researchers will take blood, bone marrow, and saliva samples. These samples will be used to look for the markers mentioned earlier. The visits will be scheduled at key times throughout the study period.

In addition to giving samples, you'll be asked about your experiences of living with your condition. This includes discussing any symptoms you might have, how you're feeling generally, and if you've developed any other health problems like infections or blood clots. The study does not involve taking any new medications; it's purely about observing and collecting information and samples over time. The total duration of your participation will be up to five years.