CompletedInterventional

Breast cancer risk reduction through family-based lifestyle change

This study in Manchester explores a 12-week family-based programme to help mothers at increased risk of breast cancer reduce their risk. Living with overweight or obesity is linked to a higher chance of developing breast cancer, and losing even a small amount of weight can help. The programme, called B-FAM, guides mothers to make healthy changes to their diet and physical activity, encouraging family involvement to support these changes. It aims to see if mothers and their families find this kind of programme acceptable and practical. Mothers suitable for the study are over 18, have children under 18 living with them, and have an increased risk of breast cancer.

At a glance

Status

Completed

Sponsor

University of Manchester

Enrolment target

Start

01 Feb 2026

Estimated completion

30 Apr 2026

Prevention of breast cancer in women at increased risk

What is this study about?

Breast cancer is a common cancer in women in the UK, and being overweight or obese can increase the risk. Research shows that losing just a small amount of weight, even 5-10% of your body weight, can help reduce this risk. However, we know that many mums find it hard to lose weight, especially when juggling family life, work, and childcare. Family routines and the types of food available at home can really affect a woman's ability to reach a healthy weight.

This study wants to find out if a family-based weight loss programme is a good idea and practical for mothers who are overweight or obese and have been told they're at a higher risk of breast cancer. These women would typically have been identified through NHS family history or genetic clinics. The programme, called B-FAM, will help mothers lose weight through healthier eating and more physical activity. It teaches practical skills like meal planning and encourages family support.

The results of this study will help us understand if this type of family-focused approach is worth looking into further. If successful, it could help shape future support services for women at increased risk of breast cancer, providing a new way to help them live healthier lives and potentially lower their risk.

Key takeaways

It's for mothers at higher breast cancer risk who are overweight or obese.
A 12-week programme focusing on diet and physical activity.
Led by a dietitian with family involvement encouraged.
Aims to check if this type of programme is practical.
Takes place in Manchester with some remote support.
You can leave the study at any time.

Who may be eligible?

To join this study, you need to be a woman aged 18 or over. You must have been told by an NHS clinic that you have a moderate or high risk of getting breast cancer. You also need to be overweight or obese, based on your Body Mass Index (BMI).

It's important that you live with children aged 17 or under, and speak English or another language that can be supported by the study team. You should also be able to come to two face-to-face appointments in Manchester.

There are also some reasons why you might not be able to join. For example, if you've already had cancer (except for certain skin cancers), are pregnant or breastfeeding, or are taking certain weight-loss medications. The study also cannot include those with severe mental health conditions or eating disorders, or those currently in other weight loss programmes.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you a woman aged 18 or older?
Has an NHS clinic told you that you have a higher risk of breast cancer?
Are you overweight or obese?
Do you have children aged 17 or under living with you?
Can you attend two in-person visits in Manchester?
Are you not currently pregnant or breastfeeding, and not undergoing other weight loss programmes?

Answer every question to see your result.

What does participation involve?

If you decide to take part, you'll join a 12-week programme focused on healthy eating and physical activity. Before the programme starts and again at the end, you'll have a face-to-face visit in Manchester. During these visits, we'll measure your weight, body fat, and muscle using special scales. You'll also fill out questionnaires about what you eat, how active you are, and your drinking habits, and keep a food diary for 7 days.

Throughout the 12 weeks, you'll receive personalised healthy eating and activity advice designed to help you lose about 1 to 2 pounds (0.5–1 kg) per week. You'll have regular catch-ups with a dietitian every two weeks. These will be by phone, video call, or email, covering topics like meal planning and dealing with emotional eating. While the main focus is on your weight loss, you'll be encouraged to get your family involved in healthy eating and physical activity at home.

Potential risks and benefits

While we can't promise specific health benefits, some women might find they lose weight, get fitter, or feel more supported by their family. You'll also get personalised advice from a dietitian and learn practical skills for a healthier lifestyle, potentially involving your family in positive changes. Importantly, your participation will help improve future NHS services for women at higher breast cancer risk. The study is generally low-risk, following standard healthy eating guidance, but discussing weight, body image, family, or cancer risk can sometimes be upsetting. If you feel distressed, you can pause or stop a session, or leave the study at any time without giving a reason. The study team can also provide information about family therapy or other support if needed.

Locations (1)

Wythenshawe Hospital
Approximate
Manchester, England

Common questions

What is the main goal of this study?

The main goal is to see if a family-focused health programme is practical and helpful for mothers at higher risk of breast cancer to lose weight and reduce their risk.

How long does the study last?

The main healthy lifestyle programme lasts for 12 weeks.

Do my children have to officially join the programme?

No, the weight loss focus is on the mother, but you'll be encouraged to involve your family in healthy eating and activities at home.

Where does the study take place?

The face-to-face parts of the study will be held at Manchester University Hospital Foundation NHS Trust.

Who is paying for this study?

The study is funded by the National Institute for Health and Care Research (NIHR) Manchester Biomedical Research Centre (BRC).

How to find out more

Mai Haiba

mai.haiba@postgrad.manchester.ac.uk +44 161 291 5815 Official trial record

Always speak to your GP or specialist before deciding to take part in a study.