Ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence StudyInterventional

A Study to Learn How Different Forms of The Study Medicine Called Prazosin Are Taken up Into the Blood in Healthy Adults

This research is a Phase I study, which means it's an early look at a medicine called Prazosin. The main goal is to understand how different forms of this medicine are absorbed into the body and get into the bloodstream of healthy adults. Prazosin is a treatment used for high blood pressure and heart failure. This study helps scientists learn more about how the medicine works, which can improve treatments for these conditions in the future. It's not testing a new medicine, but rather different ways an existing one is given.

At a glance

Status

Ongoing, recruiting

Phase

Human Pharmacology (Phase I)- Bioequivalence Study

Sponsor

Pfizer Inc.

Enrolment target

Start

10 Oct 2025

Primary and secondary hypertension and heart failure

What is this study about?

This study is about a medicine called Prazosin, which is currently used to treat conditions like high blood pressure (hypertension) and heart failure. When doctors talk about primary hypertension, they mean high blood pressure that doesn't have an obvious cause, while secondary hypertension is high blood pressure caused by another health problem. Heart failure means your heart isn't pumping blood as well as it should. This study isn't testing whether Prazosin works, as we already know it does; instead, it's looking at how the body absorbs it.

Specifically, this research is trying to understand how different versions or forms of Prazosin get into your blood. This is often called a 'bioequivalence study.' It means researchers want to see if different ways of making or giving the medicine result in the same amount of medicine reaching your bloodstream and doing its job effectively.

Understanding how medicines are absorbed is really important. It helps ensure that patients always get the right amount of medication in their system, no matter the specific pill or type of Prazosin they are prescribed. This research could help improve how Prazosin is made or prescribed in the future, making sure it's as effective as possible for people who need it.

Key takeaways

The study is about an existing medicine called Prazosin.
It's checking how Prazosin gets absorbed into the blood.
Healthy adults (18+) can take part.
It helps improve future treatments for high blood pressure and heart failure.
Participation involves clinic visits and blood tests.
It's a very early-stage research study.

Who may be eligible?

This study is looking for healthy adult volunteers, aged 18 years and older (there isn't an upper age limit mentioned). Both men and women are welcome to take part.

To be considered healthy for this type of research, you would generally need to be overall well, without any major ongoing health conditions or medications that could affect how your body handles the study medicine.

Because this is a study about how a medicine is absorbed, volunteers will likely need to meet specific health criteria to ensure the results are clear and not influenced by other health issues.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you 18 years old or older?
Are you generally healthy?
Are you willing to have blood tests?
Are you able to attend clinic visits as required?
Are you happy to take a study medicine as directed?

Answer every question to see your result.

What does participation involve?

Taking part in this study would involve a few visits to a clinic. You would be given different forms of the study medicine, Prazosin, and the research team would then take blood samples from you at set times over a period. This is to check how quickly and how much of the medicine gets into your blood. There might also be other general health checks, like blood pressure or heart rate monitoring. After the study medication is given, you would be carefully monitored for any effects. The total duration of your participation, including all visits and follow-up, would be fully explained before you agree to join.

Potential risks and benefits

The potential benefit of taking part is contributing to medical knowledge that could improve treatments for high blood pressure and heart failure in the future. As with any study involving medication, there are potential risks, which will be fully explained to you. These might include common side effects associated with Prazosin (like dizziness) or discomfort from blood draws. You have the right to withdraw from the study at any time, for any reason, without it affecting your medical care.

Locations (1)

Some site locations are approximate. We're improving this — please verify with the trial team before travelling.

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Unverified
Belgium

Common questions

What is Prazosin?

Prazosin is a medicine used to treat high blood pressure and heart failure.

What does 'Phase I' mean?

Phase I is an early stage of research, often looking at how a medicine is handled by the body in healthy volunteers.

Will I get paid for taking part?

Payment for participation varies between studies and will be discussed before you join, usually covering time and travel expenses.

Do I need to have high blood pressure to join?

No, this specific study is looking for healthy adults. It's not testing the medicine's effect on illness, but how it's absorbed.

How long will the study last for me?

The exact duration for your participation will be explained in detail by the study team, as it can vary.