RecruitingNAINTERVENTIONAL

Primary Failure of Eruption (PFE) : Highlighting of Clinical, Radiological and Genetic Diagnostic Criteria: Consequences on the Therapeutic Management

This research focuses on a rare dental condition known as Primary Failure of Eruption (PFE). This is when adult teeth don't fully grow into their correct position. The study aims to pinpoint clear symptoms, X-ray findings, and genetic links that can help diagnose PFE. Researchers will also investigate how different genetic changes might lead to different symptoms of PFE, and why some treatments don't work as expected. The goal is to gather better information to improve how dentists and doctors identify and manage this condition. Participants will undergo various scans, including X-rays and possibly CT scans, and provide samples for genetic testing.

At a glance

Status

Recruiting

Phase

Sponsor

University Hospital, Strasbourg, France

Enrolment target

Start

22 Oct 2018

Estimated completion

12 Oct 2025

Primary Failure of Eruption

What is this study about?

This study is all about understanding a rare condition called Primary Failure of Eruption, or PFE. Imagine your adult teeth trying to grow into place, but for some reason, they just don't make it all the way. That's PFE. Currently, it can be tricky to properly diagnose, and treatments don't always work as well as everyone hopes.

The main aim of this research is to get a clearer picture of PFE. Doctors want to identify very specific signs they can look for in your mouth, what it should look like on different types of X-rays, and if certain genes play a role. By finding these clear markers, it should become much easier to diagnose PFE consistently and correctly. This means people can get the right care sooner.

Beyond just diagnosis, the study also wants to see if particular genetic changes are linked to different types or severities of PFE. They're also looking into why some treatments for PFE don't succeed. This information is vital because it could lead to new, more effective ways to manage the condition, giving people with PFE better outcomes and happier smiles.

Key takeaways

Researchers want to improve how Primary Failure of Eruption (PFE) is diagnosed.
The study looks for signs of PFE in the mouth, on X-rays, and in genes.
It aims to understand why some treatments for PFE might not work well.
Participation involves various scans and genetic testing.
This research could lead to better future treatments for PFE.

Who may be eligible?

To join this study, you need to be at least 6 years old and have been diagnosed with Primary Failure of Eruption (PFE) where your teeth haven't grown into place properly.

There are some reasons why you wouldn't be able to join. If you're under 6 years old, you won't be able to take part. Also, if you have other health conditions that affect how your teeth grow, or certain medical treatments, then this study might not be suitable for you.

Specifically, if you have conditions like rickets, or are undergoing chemotherapy or radiotherapy, or taking certain medications called bisphosphonates, you wouldn't be able to join. These conditions or treatments could affect the results, so the researchers need to focus on people where PFE is the main issue.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you 6 years old or older?
Have you been told you have Primary Failure of Eruption (PFE)?
Do you have any endocrine conditions that affect teeth?
Are you currently having chemotherapy or radiotherapy?
Are you taking bisphosphonate medication?

Answer every question to see your result.

What does participation involve?

If you decide to take part in this study, you would undergo several assessments. These would likely include different types of X-rays, such as panoramic X-rays (which show all your teeth), teleradiography (a side-view X-ray of your head), and X-rays of individual teeth inside your mouth. You might also have a CT scan of your upper and lower jaws, which gives a detailed 3D image. Additionally, you would provide a sample for genetic analysis, which might involve a blood test or a swab from inside your cheek. The study aims to gather information at one point in time; it's not described as involving ongoing visits or medication. The total duration would depend on how long it takes to complete all the necessary tests and appointments.

Potential risks and benefits

Taking part in this study could help doctors better understand and treat Primary Failure of Eruption in the future. You wouldn't directly receive treatment as part of this study, but your information would contribute to medical knowledge. There are some minor risks, mainly from the X-rays and CT scans, which involve a small amount of radiation, similar to what you encounter naturally. Blood tests carry a small risk of bruising or discomfort. You are free to withdraw from the study at any time without giving a reason, and it won't affect your future medical care.

Locations (1)

Clinique dentaire
Verified postcode
Strasbourg, France· Recruiting

Common questions

What is Primary Failure of Eruption (PFE)?

It's a rare dental condition where adult teeth don't fully grow into their proper position in the mouth.

Why is this study important?

It aims to find clearer ways to diagnose PFE and understand why some treatments don't work, which could lead to better care for people with the condition.

Will I receive treatment if I join?

No, this study is about gathering information to improve future understanding and treatment of PFE, not providing direct treatment to participants.

Does taking part involve needles?

You might have a blood test for genetic analysis, which involves a needle, or they might take a swab from inside your cheek if that's an option.

How long will I be involved in the study?

The study collects information at one point in time, so your involvement would be for a limited number of appointments to complete the necessary scans and tests.

How to find out more

Marion STRUB, Doctor

marion.strub@chru-strasbourg.fr 388116956 Official trial record

Always speak to your GP or specialist before deciding to take part in a study.