Study Evaluating LDL-C Change and Adherence to Inclisiran Lipid-lowering Therapy in ASCVD

To join this study, you need to be an adult, 18 years or older, and have high cholesterol. You must also have a diagnosis of certain heart or blood vessel diseases (like previous heart attack or stroke) or be at high risk of developing them, or have a specific genetic type of high cholesterol called HeFH.

Crucially, your current cholesterol-lowering medicines should not have brought your LDL-C down to the level your doctor aims for, based on health guidelines. This study is for people whose doctors feel they need to improve their cholesterol treatment, and who are just starting inclisiran as part of their regular care.

You cannot join if you've already had inclisiran before, or if you're currently in another study testing a new medicine. Also, if you've recently switched from another similar cholesterol-lowering injection (called a PCSK9 inhibitor) within the last three months, you wouldn't be able to take part.

If you join this study, your doctor will enrol you while you begin treatment with inclisiran, which will be prescribed as part of your normal care. You won't be given any experimental medicines; you'll receive inclisiran according to how it's usually prescribed in the UK. Researchers will collect information from your routine doctor visits over a period of up to 24 months (two years). They will look at your cholesterol levels at the start of the study and throughout your treatment. They'll also observe whether you're taking your inclisiran as planned. You'll continue to have your regular appointments and tests as recommended by your doctor, and the study will gather information from these visits. There won't be extra visits or special tests just for the study; it's all about observing your care as it happens.