A Study to Evaluate Ocrelizumab Treatment in Participants With Progressive Multiple Sclerosis

To join this study, you need to be an adult between 18 and 65 years old and have a clear diagnosis of progressive multiple sclerosis (PMS). Your disability level, as measured by a common scale called EDSS, should be 6.5 or less. You also need to have shown a worsening of your disability in the last two years, which wasn't clearly caused by a sudden MS relapse.

Other important points include being comfortable using a smartphone and connecting to Wi-Fi. If you're a woman who could become pregnant, you'll need to agree to use effective birth control throughout the study and for some time afterwards. Certain health conditions, like other neurological diseases, difficulty having an MRI scan, or active infections, would mean you couldn't take part. Also, if you are pregnant, breastfeeding, or need ongoing treatment with certain strong medications like steroids, you wouldn't be able to join.

This study will involve regular visits to the clinic where you'll receive the ocrelizumab medicine. During these visits, doctors and nurses will carry out various checks and tests, like blood tests and neurological exams, to monitor your health and how the treatment is affecting you. You'll also be asked to provide information about your symptoms and how you're feeling using a smartphone.

The total amount of time you'll be involved in the study will vary, but it's a long-term study designed to observe the effects of ocrelizumab over an extended period. The study will continue to gather information about your health and any effects of the medicine for some time after your last dose. The team will provide you with a detailed schedule of visits and what to expect at each appointment.