Not yet recruitingNAINTERVENTIONAL

Urinary Proteomics Combined With Home Blood Pressure Telemonitoring for Health Care Reform

This study, called UPRIGHT-HTM, is for people aged 55-75 who don't have symptoms but might be at risk of heart or kidney problems, especially if they have high blood pressure or type 2 diabetes. It aims to find better ways to spot these risks early. Participants will check their blood pressure at home and provide urine samples for a special test. This new urine test looks for specific proteins. Researchers want to compare if combining home blood pressure monitoring with this urine test is better than just monitoring blood pressure at home. The goal is to see if this combined approach helps doctors personalise care, prevent serious conditions like heart attacks or strokes, and if it's a good value for health services.

At a glance

Status

Not yet recruiting

Phase

Sponsor

KU Leuven

Enrolment target

1,000

Start

01 Apr 2020

Estimated completion

31 Jul 2026

Protein Deregulation Blood Pressure Health Care Utilization Cost Effectiveness Patient Empowerment

What is this study about?

This study is about finding better ways to predict and prevent serious health problems like chronic kidney disease and heart issues, which often become more common as people get older. Many people have a higher risk for these conditions, especially if they have high blood pressure or type 2 diabetes, even if they don't feel unwell yet. Catching these risks early means doctors can offer the right treatments sooner, which could make a big difference to people's health in the long run.

Currently, checking your blood pressure at home is a good way to keep an eye on your heart health. This study is exploring if adding a new type of urine test could make this even better. This special urine test looks for tiny protein clues that might show up early if your kidneys or heart are starting to have problems. By combining home blood pressure checks with this advanced urine test, the researchers hope to create a more accurate picture of someone's health risks earlier than before.

The main goal is to see if this combined approach helps healthcare services deliver more effective and affordable care. They want to find out if it leads to better treatment plans, reduces the number of people who develop serious heart or kidney problems, and ultimately improves people's health in different places around the world.

Key takeaways

Study for 55-75 year olds at risk of heart/kidney problems.
Compares home blood pressure monitoring with a new urine test.
Aims to find better ways to predict and prevent serious health issues.
Involves daily home blood pressure checks and urine samples.
Could help improve future healthcare and patient outcomes.
Participation involves long-term follow-up (around 4 years).

Who may be eligible?

This study is looking for volunteers between 55 and 75 years old.

You might be suitable if you don't currently have major health symptoms but have at least three risk factors for heart or kidney problems. These risk factors often include high blood pressure or type 2 diabetes. You'll need to be comfortable using the internet and have an email address, as a big part of the study involves monitoring your blood pressure at home and sending the results online.

There are also some reasons why you wouldn't be able to join. For example, if you have type 1 diabetes, a severe heart condition, have had cancer in the last five years, or are taking certain medications that can affect your kidneys. The research team will carefully check all applicants to make sure the study is safe and appropriate for them.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you between 55 and 75 years old?
Do you have at least three risk factors for heart or kidney problems (e.g., high blood pressure, type 2 diabetes)?
Are you comfortable using the internet and have an email address?
Are you willing to check your blood pressure daily at home for some time?
Do you *not* have type 1 diabetes or a history of severe heart/kidney disease?
Have you *not* had cancer in the last 5 years?

Answer every question to see your result.

What does participation involve?

If you join this study, you will be asked to monitor your blood pressure at home once a day using a special device. You'll need to be able to send these readings online. You will also provide urine samples for a new diagnostic test. The study is divided into two groups: one group will use home blood pressure monitoring only, and the other will combine it with the special urine test. The study involves regular check-ups to track your health over time.

The total duration of your involvement could be around 4 years, following an initial enrolment period of about 1 year. During this time, the research team will explain everything to you and provide support. There aren't specific details provided about the exact number of hospital visits, but you will have follow-up appointments.

Potential risks and benefits

Participating in this study might offer several benefits. You'll receive careful monitoring of your blood pressure and potentially have early insights into your heart and kidney health. This could lead to earlier interventions if any issues are detected. The study aims to improve health for future patients. As with any study, there could be some minor inconveniences like the time commitment for blood pressure readings or clinic visits. However, all procedures are designed to be as safe as possible. You are always free to withdraw from the study at any time and for any reason, without it affecting your usual medical care.

Locations (12)

Some site locations are approximate. We're improving this — please verify with the trial team before travelling.

European Kidney Health Aliance
Verified postcode
Brussels, Belgium
Diabetes Liga
Verified postcode
Ghent, Belgium
Alliance for the Promotion of Preventive Medicine
Verified postcode
Mechelen, Belgium
Steno Diabetes Center Copenhagen
Verified postcode
Gentofte Municipality, Denmark
Mosaiques-Diagnoostics and Therapeutics AG
Verified postcode
Hanover, Germany
Biomedical Research Foundation of the Academy of Athens
Verified postcode
Athens, Greece
Department of Internal Medicine, Faculty of Clinical Sciences, College of Health Sciences, University of Abuja
Verified postcode
Abuja, Nigeria
Department of Hypertension, Medical University of Gdańsk
Verified postcode
Gdansk, Poland
First Department of Cardiology, Interventional Electrocardiology and Hypertension, Jagiellonian University Medical College
Verified postcode
Krakow, Poland
Department of Internal Medicine, Division of Hypertension, University Medical Centre Ljubljana
Verified postcode
Ljubljana, Slovenia
Hypertension in Africa Research Team, Medical Research Council Unit for Hypertension and Cardiovascular Disease, North-West University
Verified postcode
Potchefstroom, South Africa
Centro de Nefrología and Departamento de Fisiopatología, Hospital de Clínicas, Universidad de la República
Verified postcode
Montevideo, Uruguay

Common questions

What is 'home blood pressure telemonitoring'?

It means you check your blood pressure at home using a special device and send the readings electronically, often through the internet, to a healthcare team.

What is a 'urine proteomic test'?

It's a special urine sample analysis that looks for very tiny proteins or protein bits. These can sometimes give early clues about your kidney or heart health.

Do I need to have a specific health problem to join?

No, you don't need to have symptoms, but you should have certain risk factors like high blood pressure or type 2 diabetes, even if you don't feel unwell.

How long will I be in the study?

The study aims for participants to be followed for about 4 years after an initial enrolment period.

Will I get free treatment if I join?

The study is focused on monitoring and diagnosis. Any treatment decisions would still be made by your doctor based on your overall health.

How to find out more

Jan A Staessen, MD, PhD

jan.staessen@med.kuleuven.be +32 47 632 4928 Official trial record

Always speak to your GP or specialist before deciding to take part in a study.