PODOMOUNT-Basket, a Study to Test Whether BI 764198 Helps Adults and Adolescents With Different Types of Kidney Disease

This study is mainly for adults aged 18 and over with certain kidney conditions. However, teenagers aged 12 and above who have a type of kidney disease called Minimal Change Disease (MCD) that hasn't responded to other treatments can also be considered.

To be eligible, your weight needs to be at least 40 kg, and your Body Mass Index (BMI) should be 40 or less. Your kidneys should also be working at a certain level, which doctors will check with a specific blood test. Your blood pressure needs to be within certain limits when measured by the study doctors.

If you're already taking certain kidney medications, like ACE inhibitors or ARBs, you must have been on a stable dose for at least 8 weeks before joining. The same applies to other medications like MRAs, ERAs, GLP-1s, or SGLT2 inhibitors.

If you join this study, you'll be in it for about 7 months in total. You'll be asked to visit the study clinic 6 times during this period, and there will also be 3 phone calls with the study team. You'll be given either the study medicine, BI 764198, or a dummy pill (placebo), which looks identical but contains no medicine. There's a higher chance (twice as high) of getting the actual study medicine than the dummy pill.

Both the study medicine and the dummy pill are taken as tablets once a day for 20 weeks. Throughout the study, you'll continue to take your usual kidney medications as prescribed by your doctor. The study team will regularly check your health, which includes providing urine samples to measure protein levels and having blood samples taken to check your kidney function. They will also carefully record any side effects you might experience.