Risk-benefit analysis of intrathecal morphine administration to patients undergoing surgical treatment of proximal femoral fracture (monocentric, single-blinded, randomized clinical study compared to standard treatment)

This study is about making sure people who've broken their hip (often called a 'proximal femoral fracture') have the best possible pain relief during and after their surgery. A broken hip is a serious injury, and managing the pain effectively is very important for recovery. The study is comparing a specific way of giving a strong painkiller called morphine to the usual pain relief methods. Instead of just giving morphine through a drip or as a tablet, this study involves giving a small amount of morphine directly into the fluid around the spinal cord during the operation.

The main aim is to see if this method reduces pain more effectively than standard care. They'll be checking how much pain people feel both when they're resting and when they're moved, especially in the first 24 hours after surgery. The study also wants to find out if giving morphine this way means people need fewer other painkillers, how quickly they need more pain relief after surgery, and the total amount of strong painkillers (opioids) they use while in intensive care.

Researchers are also looking at other important things. They'll be monitoring for common side effects of strong painkillers, such as problems with breathing (hypoventilation), low blood pressure (hypotension), a slow heart rate (bradycardia), and feeling sick or vomiting after the operation. They'll also check for itching and how well any treatment for itching works. This detailed look helps them understand the full benefits and any potential downsides of this pain relief method.