A Study of Brenipatide (LY3537031) in Adult Participants With Moderate-to-Severe Chronic Obstructive Pulmonary Disease (COPD)

To be considered for this study, you would need to be an adult between 40 and 75 years old with a confirmed diagnosis of moderate to severe COPD. You must have been diagnosed with COPD at least a year ago. We're looking for people who are current or former smokers, with a smoking history equivalent to smoking at least 20 cigarettes a day for 10 years.

Your COPD should be making breathing quite difficult, to the point where it affects your daily life. Also, in the past year, you should have had at least two flare-ups (times when your symptoms got much worse and needed treatment) or one very serious flare-up. You must also be on a stable dose of your current COPD medicines (either a 'double' or 'triple' inhaler combination) for at least three months before the study starts.

There are also some reasons why you might not be able to join. For example, if you have another significant lung condition that isn't COPD, or if you have a current or recent active infection before the study begins, you wouldn't be able to participate.

If you decide to take part, you would be involved in the study for about one year. During this time, you would have regular visits to the study clinic. At these visits, doctors and nurses would check your health, ask about your symptoms, and carry out some tests. These tests might include breathing tests to measure your lung function and blood tests.

You would receive either the new medicine, Brenipatide, or a placebo (a dummy medicine). Neither you nor your study doctor would know which one you are receiving. You would also continue taking your usual COPD medications as prescribed. The study team would carefully monitor how you are doing throughout this period. It's important to attend all scheduled visits so the researchers can gather all the necessary information.