Efficacy of Lenses in Abolishing Photoparoxysmal Responses
This research is testing new types of glasses lenses for young people aged 5 to 18 who have photosensitive epilepsy. This is a type of epilepsy where seizures can be triggered by flashing lights or patterns. Some blue-tinted lenses are already used for this, but they can make it hard to see certain colours and might not be good for long-term eye health. The study aims to find out if four new lenses work just as well as, or better than, an existing blue lens (Z1 lens) at reducing these brain reactions. Researchers will use a special brain scan (EEG) to check the brain's response while wearing different lenses. They also want to know if patients find the new lenses comfortable and if they improve their quality of life.
At a glance
What is this study about?
Photosensitive epilepsy (PSE) is a type of epilepsy where seizures are triggered by certain visual things, like flashing lights (from TVs, video games, or even sunlight) or strong patterns. When someone with PSE sees these triggers, their brain can have a strong reaction, which doctors call a ‘photoparoxysmal response’ (PPR). This reaction can lead to a seizure.
Currently, some people with PSE use special blue-tinted glasses lenses, like the Z1 lens, which are designed to filter out red light. These lenses have shown to be helpful in reducing these brain reactions. However, they let very little light through and can make it difficult to see some colours, especially red and yellow. There's also a concern that letting through mostly blue light might not be good for the eyes in the long run.
This study wants to explore whether four new types of lenses, with different ways of filtering light, can be just as effective as the Z1 lens, or even better, at calming down these brain reactions in young people with PSE. The aim is to find lenses that work well but might be more comfortable, allow clearer vision of all colours, and be safer for eyes over time. The researchers will be comparing the new lenses to the Z1 lens in the same individuals to see which works best.
Key takeaways
- New glasses lenses are being tested for photosensitive epilepsy.
- The study is for children and teenagers (5-18 years old).
- It aims to find lenses that reduce brain reactions to light triggers.
- Researchers will compare new lenses to an existing blue lens (Z1).
- Participation involves an EEG scan and potentially trying the new lenses.
- The goal is to improve comfort and vision for people with photosensitive epilepsy.
Who may be eligible?
This study is looking for children and teenagers between 5 and 18 years old who have been diagnosed with, or are thought to have, photosensitive epilepsy. This includes those who are currently taking epilepsy medication and those who aren't.
To take part, participants need to be able to focus during the study activities and follow simple instructions. If you're under 16, your parents or guardians will need to agree, and you'll also need to say you're happy to take part. If you're 16 to 18, you can agree to take part yourself after understanding what's involved.
You wouldn't be able to join the study if you have conditions that might make it hard to do the tests or understand the information, such as certain learning difficulties or autism. Also, if you find it difficult to understand English, or if you refuse to take part, you wouldn't be eligible. Girls and young women who are pregnant or might be pregnant also cannot join. If you have a generalised seizure during the brain scan, you also wouldn't be able to continue in the study.
Could this study suit you?
Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.
- Is my child aged between 5 and 18?
- Does my child have photosensitive epilepsy?
- Can my child follow simple instructions and concentrate?
- Is my child able to understand explanations in English?
- Is my child not currently pregnant (if female)?
What does participation involve?
If you decide to take part, your child will have a special brain scan called an EEG. During this scan, they will be shown flashing lights and patterns. They'll wear different study lenses during this, including the Z1 lens and the four new experimental lenses, to see how their brain reacts. We'll compare these reactions.
After this, some participants might be asked to try out a pair of the new lenses for a period of time. You'll be asked to complete questionnaires about how well your child tolerates the lenses, how often they wear them, and if they feel their quality of life or seizure frequency has improved. The total duration of participation will vary depending on whether you only do the initial EEG testing or also try the lenses afterwards.
Potential risks and benefits
Locations (2)
- Birmingham Women's and Children's NHS Foundation TrustVerified postcodeBirmingham, United Kingdom
- Aston UniversityVerified postcodeBirmingham, United Kingdom
Common questions
What is photosensitive epilepsy?
It's a type of epilepsy where flashing lights, patterns, or screens can trigger seizures.
What is an EEG scan?
An EEG is a safe and common test that measures electrical activity in the brain through sensors placed on the scalp.
Will my child have to take new medication?
No, this study is only about testing different glasses lenses, not new medication.
Will I know which lens works best for my child?
The study aims to compare the lenses, and researchers will discuss the findings with you.
Can I leave the study at any time?
Yes, you or your child can choose to stop participating in the study at any point, for any reason.
How to find out more
Always speak to your GP or specialist before deciding to take part in a study.
Discussion
Community discussion
Powered by our forum at community.patient.info. Please be respectful — this is not medical advice.