Study to Assess the Efficacy, Safety, and Tolerability of NOC-110 in Adults With Refractory or Unexplained Chronic Cough

To join this study, you need to be an adult between 18 and 80 years old who has had a chronic cough for at least 12 months that hasn't responded to treatment or has no clear cause. If you are a woman who could become pregnant, or a man whose partner could become pregnant, you would need to agree to use specific birth control methods throughout the study.

There are several reasons why you might not be able to join. For example, if you've ever taken the study medicine before, or if you're allergic to it, you wouldn't be eligible. You also can't be in another drug study at the same time, or have been in another cough study recently. If you have certain other health conditions like severe lung diseases (such as COPD or asthma), unexplained lung scarring, or a recent chest infection, you wouldn't qualify. Those who currently smoke or vape, or have stopped very recently, also cannot take part. Additionally, if you're pregnant, breastfeeding, or planning to become pregnant, you cannot join.

Other reasons that might prevent you from joining include a history of certain serious illnesses like cancer in the last two years, poorly controlled heart, kidney, or other major health conditions, a high BMI (over 40), or if you're unable to avoid certain cough medicines during the study. The study also cannot accept individuals with HIV, Hepatitis B or C, or those with certain drug or alcohol issues in the last two years.

If you decide to take part in this study, you would first go through a screening process to make sure you meet all the requirements. This could involve medical checks and answering questions about your health history. The study itself would last for about 13 weeks. During this time, you would attend several appointments at the study clinic. These visits would involve taking the study medicine (either NOC-110 or a dummy medicine), having medical assessments, and discussing how you are feeling and if your cough has changed. You'd be monitored closely to check for any side effects and to see how the medicine is affecting your cough. The full details of the schedule and different assessments would be explained to you before you agree to participate.