RecruitingOBSERVATIONAL

International Leukemia Target Board

The International Leukemia Target Board (iLTB) is a project designed to help children and young people up to age 25 who have blood cancers that have come back or are difficult to treat. Across Europe, a team of medical experts looks at each patient's specific cancer details, like genetic information and how the cancer has responded to past treatments. They then offer expert advice to the patient's local doctor about the most promising treatment options available. This project doesn't involve new medicines or tests; it's about providing guidance and collecting information to see how well these expert recommendations work for patients over time. The goal is to improve the chances of finding effective treatments for these challenging situations, especially when standard treatments have not been successful.

At a glance

Status

Recruiting

Sponsor

Princess Maxima Center for Pediatric Oncology

Enrolment target

600

Start

31 Dec 2022

Estimated completion

01 Jun 2032

Relapsed Hematologic Malignancy Refractory Hematologic Malignancy

What is this study about?

When children and young people have blood cancers that are difficult to treat – meaning they've come back after treatment or haven't responded well to standard care – finding the best next steps can be very challenging. Often, there might be many different ways doctors could try to help, but it's hard to know which one will work best for that particular person. This is where the International Leukemia Target Board (iLTB) comes in.

The iLTB is a special group of many different types of medical experts from all over Europe, including cancer specialists, geneticists, and data scientists. Their job is to look at all the detailed information about a patient's cancer, like its genetic makeup and how it has behaved before. They also consider things like the patient's past treatments and their overall health goals, for example, if they are preparing for a stem cell transplant or another advanced therapy. Based on all this information, the iLTB team gives advice to the patient's local doctor about the most suitable treatment options.

It's important to understand that the iLTB itself doesn't provide medical treatment or prescribe new drugs. Instead, it offers a second opinion and expert guidance. The project also keeps a record of the advice given and what treatments patients actually receive, and then tracks how patients are doing. This helps the medical community learn what works best for different types of hard-to-treat blood cancers, improving knowledge and care for future patients.

Key takeaways

Expert team gives advice for hard-to-treat blood cancers.
For children and young people up to age 25.
No new tests or clinic visits required.
Aims to find better treatment options.
Information gathered helps future patients.

Who may be eligible?

This project is for children and young people who have been diagnosed with a blood cancer that has either come back after treatment or isn't responding to standard care. You must have been diagnosed with cancer before your 18th birthday, and you need to be under 25 years old when you join the project.

Your doctors must feel that you have at least six weeks of life expectancy. You also need to have had special tests recently that look closely at your cancer's genetic makeup and other markers. These test results must be available for the expert panel to review.

Finally, you and your parents or guardians (if you're under 18) must give your written permission for your medical information to be discussed by the iLTB team, following local rules. There are no specific reasons that would automatically exclude you, as long as you meet these requirements.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you under 25 years old?
Do you have a blood cancer that has come back or is hard to treat?
Have you had special genetic tests on your cancer recently?
Are you able to give permission for your medical information to be discussed?

Answer every question to see your result.

What does participation involve?

Taking part in this project means that your medical information will be discussed by a team of experts. You won't need to visit any new clinics or have extra tests specially for this project. The experts will review your existing medical files, including results from genetic tests and other cancer markers that your local hospital has already carried out.

Based on this review, the iLTB will provide advice to your treating doctor. Your doctor will then discuss these options with you and your family. The project will also follow up on your progress by collecting information about the treatments you receive and how you are doing over time. This information is collected from your existing medical records, so it won't require any additional appointments or assessments for you. The overall aim is to gather knowledge and improve care without adding any burden to you as a patient.

Potential risks and benefits

There are no direct risks to taking part in this project, as it's purely about getting expert advice; you won't be undergoing any new medical procedures or treatments specifically for the iLTB. The potential benefit is that a broad team of international experts will review your specific case, which might help your local doctor find a more effective treatment pathway for your difficult-to-treat cancer. You have the right to withdraw your consent for your information to be discussed at any time without affecting your medical care.

Locations (7)

Some site locations are approximate. We're improving this — please verify with the trial team before travelling.

UH Gent
Verified postcode
Ghent, Belgium· Recruiting
Righospitalet
Verified postcode
Copenhagen, Denmark· Recruiting
Semmelweis
Verified postcode
Budapest, Hungary· Recruiting
Princess Máxima Center for Pediatric Oncology
Verified postcode
Utrecht, Netherlands· Recruiting
Vall d'Hebron
Verified postcode
Barcelona, Spain· Recruiting
Queen Silvia
Verified postcode
Gothenburg, Sweden· Recruiting
Newcastle Hospital
Verified postcode
Newcastle, United Kingdom· Recruiting

Common questions

What kind of cancer does this project focus on?

It focuses on blood cancers (like leukaemia and lymphoma) in children and young people that have either come back or are difficult to treat with standard methods.

Will I have to travel or get extra tests for this project?

No, you won't need to travel or have any extra tests. The experts will review your existing medical information that your local doctors have already gathered.

Who are the experts involved?

It's a team of many different specialists from across Europe, including cancer doctors, genetic experts, and scientists.

Will the iLTB directly treat me?

No, the iLTB offers expert advice to your local doctor. Your doctor will still be in charge of your treatment and will discuss any options with you.

What is the main goal of this project?

The goal is to help find the most promising treatment options for children and young people with hard-to-treat blood cancers, and to learn what works best for future patients.

How to find out more

Uri Ilan, MD

iltb@prinsesmaximacentrum.nl +31889725206 Official trial record

Always speak to your GP or specialist before deciding to take part in a study.