A Study to Assess the Safety and Anti-Tumor Activity of REGN7945 in Combination With Linvoseltamab in Adult Participants With Relapsed/Refractory Multiple Myeloma

To join this study, people generally need to be 18 years or older. You would typically have been diagnosed with multiple myeloma and have tried at least three different types of treatment in the past, including specific kinds of drugs (like one called an anti-CD38 antibody, an IMiD, and a proteasome inhibitor). Importantly, your cancer must have started growing again after your last treatment.

You would also need to be generally well enough to take part, meaning you can mostly go about your daily activities without much help, and your body's systems like your blood, liver, and kidneys need to be working reasonably well. Doctors will check to make sure your myeloma can be measured, so we can see if the treatment is working.

There are also some reasons why you might not be able to join. For example, if you have certain other specific blood conditions (like plasma cell leukaemia), if you've had certain types of transplants recently, or if you're taking high doses of steroids. People with certain severe brain or nerve conditions, or who have recently had certain vaccinations, might also not be able to participate. Your medical team will carefully review all these details to see if this study is right for you.

Unfortunately, the detailed plan for what taking part involves (like the number of visits, specific tests, or how long the total study lasts) wasn't provided in the information shared. However, in most clinical trials like this one, you can expect:

* **Regular Hospital Visits:** You would likely have frequent visits to the hospital or clinic, especially at the start of the study, for examinations, blood tests, and to receive the study medication. * **Study Medication:** You will receive either the combination of REGN7945 and linvoseltamab or linvoseltamab on its own, based on what the study design indicates. These are typically given intravenously (through a drip). * **Side Effect Monitoring:** The study team will closely monitor you for any side effects and how you are feeling generally. * **Tests and Scans:** Expect to have regular blood tests, scans (like CT or MRI), and other checks to see how your multiple myeloma is responding to the treatment and to keep an eye on your overall health. * **Questionnaires:** You might be asked to complete questionnaires about your symptoms and quality of life. * **Follow-up:** Even after you stop receiving the study medication, there will usually be a follow-up period to continue monitoring your health and the long-term effects of the treatment.

Before you agree to participate, the study team would explain everything in much more detail, including the exact schedule and what's expected of you, so you know exactly what is involved.