RecruitingNAINTERVENTIONAL

Effect of Prebiotic Sodas on Postprandial Levels of GLP-1, PYY, Transit Time and Satiety Levels: A Pilot Study

Researchers are investigating whether drinking special sodas, known as prebiotic sodas, can help healthy adults feel fuller after eating. They're also checking how these sodas affect certain natural body chemicals, called hormones (GLP-1 and PYY), that play a role in digestion and how full you feel. Participants will try different types of prebiotic sodas and a regular soda over several visits. The main goal is to understand if these new sodas could influence digestion and appetite in healthy people. This is a pilot study, meaning it's an early look to see if further, larger studies would be worthwhile.

At a glance

Status

Recruiting

Phase

Sponsor

Olipop, PBC

Enrolment target

Start

01 Jan 2026

Estimated completion

01 May 2026

Satiety in Healthy Volunteers

What is this study about?

Imagine you're trying to feel full and satisfied after a meal. This study explores whether certain sodas, which have an added ingredient called 'prebiotics' (a type of fibre), could help with that feeling. Prebiotics are known to be good for your gut health, and researchers want to see if they can also impact how full you feel and how your body digests food. They'll be looking at specific natural chemicals in your gut, called hormones (GLP-1 and PYY), which are involved in telling your brain that you've eaten enough, and also how quickly food moves through your digestive system.

Over several weeks, healthy adults will visit the research clinic and try different types of these prebiotic sodas, as well as a standard soda without the added fibre. By comparing the effects of each drink, the scientists hope to learn if these prebiotic sodas might make a difference in how people feel after eating and how their digestive system works. Because this is an early, small study, it's called a 'pilot study'. This means it's designed to see if there's enough promising information to do a bigger study in the future.

The findings from this study could help us understand more about how what we drink affects our gut and our appetite. It's a step towards learning more about how drinks with added beneficial ingredients might play a role in healthy eating patterns.

Key takeaways

This study explores how special sodas with added fibre (prebiotics) affect feelings of fullness.
It aims to understand how these drinks impact natural gut hormones and digestion.
Healthy adults will try different sodas over several visits in a randomised order.
Participants will need to follow specific rules about food, drink, and exercise before visits.
This is a small, early-stage study to see if more research is needed.
Your involvement helps us learn more about health and digestion.

Who may be eligible?

To join this study, you need to be a healthy adult between 18 and 60 years old. Your weight should be within a healthy range for your height (your BMI should be between 18 and 30), and your weight should have been stable for the past three months.

There are certain things that would mean you couldn't take part. For example, if you are pregnant or breastfeeding, have severe allergies (especially to certain pain relievers like paracetamol), or have conditions like diabetes, liver disease, or digestive problems that affect how your body absorbs food. If you've had major surgery recently, or if you regularly use certain supplements or medications, you might not be able to join. It's also important that you haven't been on antibiotics or certain diabetes medications (called GLP-1 receptor agonists) in the last two months.

The study also asks that you avoid certain activities or substances before and during your study visits, such as strenuous exercise, alcohol, smoking, certain fibre supplements, and marijuana. You also need to live in Canada and have health insurance, like OHIP, to participate.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you between 18 and 60 years old?
Is your weight generally stable and within a healthy range?
Are you able to avoid alcohol, smoking, and certain strenuous exercises before study visits?
Do you have any severe allergies or conditions like diabetes or digestive diseases?
Have you used antibiotics or certain diabetes medications in the last two months?
Do you live in Canada and have health insurance?

Answer every question to see your result.

What does participation involve?

If you decide to take part, you'll visit the clinic on a few different occasions, separated by at least one week, but no more than three weeks. During each visit, you'll drink one of the special sodas or the control soda. The type of soda you drink will be chosen at random each time, and you won't know which one you're getting.

On the days before your visits, you'll need to follow some specific instructions, like avoiding certain foods, drinks (especially alcohol), some medications, and strenuous exercise for about 24 hours. You'll also need to avoid smoking for 12 hours before and during your visit. During your visits, researchers will take measurements to see how your body reacts to the sodas, including checking your gut hormone levels and how full you feel. The total time you'll spend participating in the study, including all your visits, will be spread out over 4 to 12 weeks.

Potential risks and benefits

There are no direct medical benefits to you for participating in this pilot study, but your contribution will help researchers understand more about how certain drinks affect our bodies and feelings of fullness. As with any study, there could be minor risks, such as discomfort from blood tests or slight temporary effects from the drinks themselves, like mild stomach upset, although these types of sodas are generally considered safe. You have the right to withdraw from the study at any time, for any reason, without it affecting your medical care.

Locations (1)

Inquis Clinical Research
Verified postcode
Toronto, Canada· Recruiting

Common questions

What is a 'prebiotic soda'?

A prebiotic soda is a fizzy drink that has added fibre (prebiotics) which can be good for your gut health.

What are GLP-1 and PYY?

These are natural hormones in your body that help control how hungry or full you feel and how food is digested.

Will I know which soda I'm drinking?

No, you won't know which soda you're drinking on each visit. This helps ensure the study results are fair and unbiased.

How long does the study last?

Your total participation, including all visits, will be spread out over 4 to 12 weeks.

Is this a new medicine?

No, these are sodas being tested, not a new medicine. The study is looking at their effects on digestion and fullness.

How to find out more

Director of Clinical Operations

jcampbell@inquis.com 416-861-0506 Official trial record

Always speak to your GP or specialist before deciding to take part in a study.