Relapse Prevention Trial Evaluating KarXT Treatment in Schizophrenia

To join this study, you need to be an adult between 18 and 65 years old and have been diagnosed with schizophrenia for at least a year. You should have had a hospital stay for schizophrenia sometime in the last year, and currently be experiencing some symptoms, but not severely unwell or in a first-time episode.

There are also some requirements about your current health, such as your body mass index (BMI). You cannot have other significant mental health conditions diagnosed recently, or be at risk of suicidal thoughts. If you've previously had trouble responding to schizophrenia medications or had very long hospital stays recently, you might not be suitable for this study.

The medical team will carefully check all these points to make sure the study is a good and safe fit for everyone involved. They will use specific questionnaires and assessments, like one called PANSS, to confirm you meet the criteria.

If you decide to take part, you'll be randomly assigned to either receive the new medicine, KarXT, or a placebo (a dummy pill). You won't know which one you're getting, and neither will your study doctor, until the study is over. You'll need to attend regular appointments at the study clinic where you'll have check-ups, assessments, and receive your study medication. These appointments will involve talking about your symptoms, having physical health checks, and possibly blood tests.

The medical team will closely monitor your health and any changes you experience throughout the study. The exact number of visits and the full duration of your participation will be fully explained to you before you make any decisions. There will also be follow-up calls or visits after you stop taking the study medication to see how you are doing.