RecruitingOBSERVATIONAL

Invasive Group A Streptococcal Infection

This research is looking into serious Strep A infections in children who are admitted to hospital. Strep A is a common germ, but sometimes it can cause very severe illness, like sepsis (a dangerous reaction to an infection). The study aims to understand why some children get these serious infections and what makes them worse. Researchers are gathering information on children under 18 who have been diagnosed with a severe Strep A infection. They want to learn more about the best ways to care for these children and improve their treatment. By collecting details from hospitals, including intensive care units, they hope to get a clearer picture of these infections and how to manage them better.

At a glance

Status

Recruiting

Sponsor

Association Clinique Thérapeutique Infantile du val de Marne

Enrolment target

100

Start

01 Sep 2022

Estimated completion

01 Sep 2026

Sepsis Due to Streptococcus, Group A Risk Factors Severe Infection Medical Care Medical Complications Outcome, Fatal Therapy Strain Virulence Factors

What is this study about?

This study is focused on a type of infection caused by a common germ called Streptococcus pyogenes, often known as Strep A. While many Strep A infections are mild, sometimes they can become very serious and spread into parts of the body that are normally free of germs. This can lead to severe conditions like sepsis, which is a dangerous reaction to an infection that can affect the whole body.

The main goal of this research is to keep a record of all serious Strep A infections in children who are admitted to hospital. Researchers want to understand how often these serious infections happen and what might make a child more likely to develop a severe illness. They also want to find the best ways to treat these children and improve their care.

The study will collect information from children in hospitals, including those in intensive care. By looking at things like how the illness developed, what symptoms children had, and the specific type of Strep A germ involved, the researchers hope to explain why there might have been an increase in these types of infections. This information is very important for doctors and scientists to better understand, treat, and prevent serious Strep A infections in the future.

Key takeaways

The study helps understand serious Strep A infections in children.
It aims to improve how these infections are managed.
No new treatments or different care are given in this study.
Information is collected from existing medical records.
Participation is only for children under 18 with confirmed serious Strep A.

Who may be eligible?

This study is looking for children who are under 18 years old. This means anyone from newborn babies up to 17-year-olds.

To be included, the child must have a confirmed serious Strep A infection. This means that tests must have shown the Strep A germ in a part of the body that's normally sterile (like blood), or they have symptoms of a very serious infection such as toxic shock or a severe skin infection, and Strep A was identified.

Children definitely cannot be included if they or their parents (or legal guardians) do not want them to take part in the study. Your wishes will always be respected.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Is the person under 18 years old?
Has a doctor confirmed they have a serious Strep A infection?
Were they admitted to hospital because of this serious infection?
Do you (or they) agree to let their medical information be used for research?

Answer every question to see your result.

What does participation involve?

This is an 'observational' study. This means that children in the study will not be given any new treatments or medicines specifically for the research. Instead, the doctors and researchers will simply be collecting information about their existing medical care and their recovery. This information will come from their medical records, and possibly from interviews with parents or guardians if appropriate. There will be no extra visits to the hospital or additional tests that wouldn't normally be part of their treatment. The focus is on learning from how real patients are cared for. The total duration of participation would last for as long as their medical information is being collected for this specific study, which is usually until their discharge from the hospital or a period shortly after.

Potential risks and benefits

As this is an observational study, there are no direct medical risks or benefits to taking part, as no new treatments are given, and no extra procedures are performed. However, the information gathered could help improve care for other children with similar infections in the future. Your or your child's medical information will be kept confidential. You have the right to withdraw your child from the study at any time without it affecting their medical care.

Locations (1)

ACTIV
Verified postcode
Créteil, France· Recruiting

Common questions

What is Strep A?

Strep A is a common type of germ (bacteria). It often causes mild illnesses like sore throats, but can sometimes lead to more serious infections.

What does 'invasive' Strep A mean?

It means the Strep A germ has spread into parts of the body that are usually free of germs, like the bloodstream, which can be very serious.

Will my child get different treatment in this study?

No, your child will receive the same medical care as any other patient. This study only collects information about their illness and treatment.

Who is running this study?

The study is managed by researchers looking into health issues, sometimes linked with health organisations like Santé Publique France.

Can I say no to my child being in the study?

Yes, absolutely. If you or your child doesn't want to take part, you can say no without it affecting their medical care in any way.

How to find out more

Levy Corinne

corinne.levy@activ-france.fr 1 48 85 04 04 Official trial record

Always speak to your GP or specialist before deciding to take part in a study.