To Evaluate the Efficacy and Safety of Pegozafermin in Subjects With Severe Hypertriglyceridemia

To join this study, you need to be at least 22 years old. You should also be willing to keep your current medications, diet, and exercise routine consistent throughout the study period. If you're taking medication to help manage cholesterol or other fats in your blood, it needs to have been stable for at least 4 weeks before you join.

There are certain reasons why you might not be able to participate. For example, if you have certain infections like hepatitis B or C, or HIV. People with uncontrolled type 2 diabetes or a recent diagnosis (within the last 3 months) would also not be able to join, and your long-term blood sugar levels (HbA1c) need to be below a certain point. If you have type 1 diabetes, you also wouldn't be eligible.

Additionally, if you have a history of certain gallbladder issues, recent acute pancreatitis, or a specific genetic condition called familial chylomicronemia syndrome, you wouldn't be able to take part. The study team will discuss all the specific criteria with you to determine if you are a good fit.

If you decide to participate, you will receive either the study drug, Pegozafermin, or a placebo (a dummy drug). You'll have regular visits to the clinic over 26 weeks where doctors will monitor your health, take blood samples to check your triglyceride levels and other markers, and discuss how you're feeling. These visits help us understand how the drug is working and check for any side effects. You'll be asked to maintain your medication, eating, and exercise habits as consistently as possible throughout the study. The total duration of active treatment and follow-up will be outlined by the study team.