Ongoing, recruitingTherapeutic exploratory (Phase II)Interventional

VItamin C in Thermal injuRY: The VICToRY Trial A phase III multi-center randomized trial

The VICToRY (VItamin C in Thermal injuRY) trial is a study looking at how vitamin C might help people who have suffered severe burns. When someone has severe burns, their body and organs can struggle to work properly. This study aims to find out if giving a specific dose of vitamin C, compared to standard fluids like salt water or sugar water, can help prevent organs from failing. Researchers specifically want to see if vitamin C can help patients avoid needing machines to support their heart, lungs, or kidneys, and ultimately help them live longer and leave the hospital sooner. This is an important step in finding better ways to care for burn victims.

At a glance

Status

Ongoing, recruiting

Phase

Therapeutic exploratory (Phase II)

Sponsor

Queen's University

Enrolment target

339

Start

24 Jul 2023

Severely burned patients

What is this study about?

When someone has severe burns, it's a very serious injury that can affect many parts of their body, not just their skin. Sometimes, their internal organs, like their heart, lungs, or kidneys, can struggle to work properly. This can lead to a condition called 'organ dysfunction', where organs don't work as well as they should, which can be life-threatening.

This study, called the VICToRY trial, is exploring if giving vitamin C can help these severely burned patients. Vitamin C is known for its role in healing and protecting cells. Researchers want to see if giving extra vitamin C can help prevent or reduce organ dysfunction, meaning it could help organs recover and work normally again.

Ultimately, the main goal of this research is to see if vitamin C can improve how well patients recover. This includes helping them to stay alive and avoid needing machines to support their major organs, like ventilators for breathing or dialysis for kidneys. They also want to find out if vitamin C can help patients recover faster and be able to go home sooner from the hospital.

Key takeaways

The VICToRY trial explores vitamin C for severe burn patients.
It aims to improve organ function and reduce complications.
Compares vitamin C to standard hospital fluids.
Studies how quickly patients recover and leave the hospital.
Involves adults (18+) with severe burns.
All treatment is given via a drip, with careful monitoring.

Who may be eligible?

This study is looking for adults who have severe burns. You need to be at least 18 years old to take part, and there's no upper age limit. Both men and women are welcome to join.

The doctors and nurses involved in the study will carefully check if an individual's specific burn injuries and overall health are suitable. This ensures that the study is safe for everyone involved and that the results will be accurate and helpful for future patients.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you 18 years old or older?
Have you recently suffered severe burns?
Are you currently receiving care for your burns in a hospital?
Are you able to provide consent, or is a family member able to do so on your behalf if you cannot?

Answer every question to see your result.

What does participation involve?

If you are eligible and choose to take part, you would be given one of three different treatments through a drip: either vitamin C, salt water (called D5W), or a sugar water solution (called NaCl). The study is 'randomised', which means a computer will decide which treatment you receive, like flipping a coin. You won't get to choose, and often, neither you nor your doctors will know which one you are receiving.

Doctors will carefully monitor your health and recovery over the next 28 days following your burn injury. They'll keep track of how your organs are functioning, if you need any life support machines, and when you are well enough to leave the hospital. There won't be extra visits beyond your normal hospital care; all assessments will be done as part of your standard treatment.

Potential risks and benefits

Participating in this study might offer a potential benefit if vitamin C proves to be helpful in protecting organs and improving recovery from severe burns, but this is not guaranteed. There might also be risks associated with receiving any treatment, although the medicines used in this study are either standard fluids or a vitamin that is generally safe. Your doctor will discuss the known risks and benefits in detail with you. Remember, you can choose to withdraw from the study at any time, for any reason, without it affecting your medical care.

Locations (5)

Some site locations are approximate. We're improving this — please verify with the trial team before travelling.

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Unverified
Belgium
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Unverified
Germany
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Unverified
France
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Unverified
Italy
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Unverified
Portugal

Common questions

What is the main goal of this study?

The main goal is to see if vitamin C can help severely burned patients' organs work better and reduce serious health complications.

Who can take part in this study?

Adults aged 18 and over, both men and women, who have severe burn injuries can potentially take part.

What will participants receive?

Participants will receive a treatment through a drip: either vitamin C, standard salt water, or standard sugar water.

How long does the study last for each person?

Doctors will closely monitor participants for 28 days to see how their organs are recovering.

Will I know if I'm getting vitamin C?

No, it's a 'blinded' study, meaning you and your doctors usually won't know which treatment you are receiving, to keep the results fair.