STI Prophylaxis and Emergence of Antimicrobial Resistance
This study aims to understand if taking antibiotics to prevent sexually transmitted infections (STIs), specifically doxycycline after sex (often called 'doxyPEP'), changes the helpful bacteria in our bodies (our microbiome) or makes germs resistant to antibiotics. Researchers will look at men who have sex with men, both those using and not using this prevention method. They want to see how easy it is to find these changes in throat and gut samples. Over 100 participants will visit a clinic every six months. At each visit, they'll give a throat swab and a stool sample, and answer some questions. Scientists will then check the DNA in these samples to identify bacteria and see if any new antibiotic resistance has developed.
At a glance
What is this study about?
You might have heard about using antibiotics to prevent sexually transmitted infections (STIs), sometimes called 'doxyPEP'. This study is investigating how using this prevention method might affect the helpful bacteria that live inside and on our bodies, known as the human microbiome. We all have a unique mix of these bacteria in places like our gut and throat, and they play an important role in our health.
The main concern is whether regularly using antibiotics for prevention could lead to what's called 'antibiotic resistance'. This happens when germs become stronger and antibiotics stop working against them. The study wants to explore this risk by looking closely at the bacteria in people who use antibiotics for STI prevention compared to those who don't. It's a way for us to learn more about keeping people healthy while also protecting the effectiveness of antibiotics for everyone.
Specifically, this research focuses on men who have sex with men (MSM), as they are a key group who might use doxyPEP. By understanding the changes in their microbiome and any development of antibiotic resistance, the study hopes to provide valuable information. This will help doctors and patients make informed decisions about STI prevention strategies in the future.
Key takeaways
- This study explores how antibiotics for STI prevention might affect your body's natural bacteria.
- It aims to understand if antibiotic resistance becomes more common with this prevention method.
- The study involves men who have sex with men (MSM).
- Participation means occasional clinic visits to provide throat and stool samples and answer questions.
- It's an 'observational' study – no new medicines will be given to you.
- Your involvement helps us understand safer STI prevention strategies for the future.
Who may be eligible?
The study is looking for men, aged 18 or over, who have sex with men. This includes both cisgender and transgender men. You should also be able to understand what the study involves and agree to take part.
There are also some reasons why you might not be able to join. For example, if you've taken any antibiotic other than doxycycline in the last three months before the study starts. You also can't be currently receiving treatment with doxycycline for an STI.
Finally, if you've used doxycycline in the past three months for any reason other than treating an STI or preventing one, you wouldn't be able to join this particular study.
Could this study suit you?
Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.
- Are you 18 years old or older?
- Do you identify as a man (cisgender or transgender)?
- Do you have sex with men?
- Have you *not* taken any antibiotic other than doxycycline in the last 3 months?
- Are you currently *not* being treated for an STI with doxycycline?
- Have you *not* used doxycycline in the last 3 months for anything other than treating or preventing an STI?
What does participation involve?
If you decide to take part in this study, you would visit a clinic every six months. At each visit, you would provide two types of samples: a throat swab (a quick and easy swab from the back of your throat) and a stool (poo) sample. You'll also be asked to complete a questionnaire, which involves answering some questions about your health and experiences.
The researchers will then carefully examine the DNA of the bacteria from your samples to identify them and look for any signs of antibiotic resistance. This will help them understand how your body's bacteria might be changing over time.
There is no specified total duration for how long you would be followed, but the visits are every six months, and this is an observational study, meaning you wouldn't be given any medication by the study team. You are free to withdraw at any time.
Potential risks and benefits
Locations (1)
- Central and North West London NHS Foundation TrustVerified postcodeLondon, United Kingdom· Recruiting
Common questions
What is 'doxyPEP'?
DoxyPEP stands for doxycycline post-exposure prophylaxis. It's when someone takes an antibiotic called doxycycline after sex to help prevent STIs.
What is the 'human microbiome'?
This is the collection of all the helpful bacteria, viruses, and other tiny living things that live in and on our bodies, like in our gut and throat.
What does 'antibiotic resistance' mean?
It means that germs have become strong enough that antibiotics, medicines designed to kill them, may no longer work effectively.
Will I be given antibiotics in this study?
No, this study is 'observational', meaning researchers will just watch and learn from your samples and answers. You won't be given any medication as part of the study.
How often will I need to visit the clinic?
You will need to visit the clinic once every six months to provide samples and answer questions.
How to find out more
Manik Kohli, MBChB MSc
Always speak to your GP or specialist before deciding to take part in a study.
Interested in taking part?
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