RecruitingNAINTERVENTIONAL

In-clinic Endoscopic Polypectomy for Chronic Sinusitis With Nasal Polyps

This study is looking into a new way to treat chronic sinusitis with nasal polyps, a common condition that makes breathing difficult and affects daily life. Currently, surgery for polyps is done in a hospital operating room under general anaesthesia. However, a newer, simpler procedure called "in-clinic polyp removal" can be done in a doctor's office with local anaesthetic. This study aims to find out if this in-clinic removal is as good as the traditional surgery at easing symptoms. Researchers will also compare the costs and recovery times. If successful, this new method could offer patients a quicker, less expensive, and equally effective way to manage their sinusitis, potentially becoming the new standard treatment in the UK.

At a glance

Status

Recruiting

Phase

Sponsor

Ottawa Hospital Research Institute

Enrolment target

140

Start

11 Apr 2017

Estimated completion

01 Dec 2026

Sinusitis Nasal Polyps

What is this study about?

If you suffer from chronic sinusitis with nasal polyps, you know how disruptive it can be. Symptoms like daily facial pain, headaches, difficulty breathing through your nose, and losing your sense of smell can severely impact your daily life. Currently, the main treatment often involves surgery performed in a hospital operating room under general anaesthesia. This can mean long waiting lists and a significant cost to the healthcare system.

Researchers are now exploring a different approach: "in-clinic polyp removal." This procedure is much simpler, performed in a doctor's office rather than an operating room, and uses local anaesthesia to numb the area. Previous studies have hinted that this in-clinic method might improve symptoms just as much as the traditional hospital surgery.

This study aims to thoroughly compare these two treatment options. We want to see if in-clinic polyp removal is just as effective at reducing symptoms for people with chronic sinusitis and polyps. We also want to understand the differences in cost for the NHS and the recovery time for patients. If this simpler procedure proves to be as good as the more complex surgery, it could lead to quicker treatment, lower costs, and less disruption to patients' lives, potentially changing how this condition is usually treated.

Key takeaways

Compares two treatments for chronic sinusitis with nasal polyps.
One treatment is a new, simpler in-clinic polyp removal.
The other is standard surgery in a hospital operating room.
Aims to see if the clinic procedure is as effective, lower cost, and quicker recovery.
Could improve how this condition is treated in the future.

Who may be eligible?

To join this study, you need to be 18 years or older and have a diagnosis of chronic sinusitis with nasal polyps that needs surgery, even after trying other medical treatments. Your polyps must be a certain size and visible on both sides of your nose, and you should be experiencing significant nasal blockage.

We cannot include you if you are pregnant or breastfeeding. You also can't participate if your polyps are so large they change the shape of your nose, or if you have severe facial pain. If you have certain other serious health conditions like immunodeficiency, cystic fibrosis, or severe mouth abnormalities, you won't be able to join. We also need to make sure you'll be able to attend all follow-up appointments.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you 18 years old or older?
Do you have ongoing sinusitis with polyps that needs surgery?
Are your nasal polyps visible on both sides of your nose and of a certain size?
Do you have significant trouble breathing through your nose?
Are you NOT pregnant or breastfeeding?
Do you have good overall health, without certain serious medical conditions?

Answer every question to see your result.

What does participation involve?

The length of this study is not specified, but it will involve multiple appointments. You will be randomly assigned to either receive the in-clinic polyp removal or the standard endoscopic sinus surgery. Both procedures aim to remove nasal polyps and improve your symptoms. You will have regular follow-up visits to check your progress, assess your symptoms, and see how well each treatment is working. This will likely involve answering questionnaires about your symptoms and having your polyps checked by a doctor.

Potential risks and benefits

Participating in this study might offer the benefit of potentially quicker access to treatment for your nasal polyps and chronic sinusitis. Both procedures aim to improve your symptoms, and the in-clinic method could offer a faster recovery and be less invasive. As with any medical procedure, there are potential risks, which your doctor will explain in detail. These risks could include bleeding, infection, or other complications, although the in-clinic procedure is generally considered less risky than full surgery. You are free to withdraw from the study at any time without giving a reason, and your decision will not affect your future medical care.

Locations (4)

Vancouver General Hospital
Verified postcode
Vancouver, Canada· Recruiting
St. Joseph's Hospital London
Verified postcode
London, Canada· Recruiting
Ottawa Hospital Research Institute
Verified postcode
Ottawa, Canada· Recruiting
McGill University Health Center
Verified postcode
Montreal, Canada· Recruiting

Common questions

What are nasal polyps?

Nasal polyps are soft, painless, non-cancerous growths that hang down like teardrops or grapes inside your nose or sinuses. They often develop from ongoing inflammation.

What is chronic sinusitis?

Chronic sinusitis means your sinuses (the air-filled spaces in your skull behind your nose, eyes, and cheekbones) are inflamed and swollen for 12 weeks or longer, even with treatment.

What is the main difference between the two treatments?

The main difference is where and how the procedure is done. One is a simpler procedure in a clinic with local numbing, while the other is traditional surgery in a hospital operating room under general anaesthesia.

Will I get to choose which treatment I receive?

No, you will be randomly assigned to one of the two treatment groups. This helps researchers fairly compare how well each treatment works.

Why is this study important for the NHS?

If the simpler, in-clinic procedure works just as well, it could save the NHS a lot of money and shorten waiting lists, allowing more people to get treatment quicker.

How to find out more

Andrea Lasso, MSc

alasso@toh.ca 6137985555 Official trial record

Always speak to your GP or specialist before deciding to take part in a study.