Long-term Follow-up Study for Participants of Kite-Sponsored Interventional Studies Treated With Gene-Modified Cells
This study is gathering important information about people who have previously received gene-modified cell therapies in other studies sponsored by Kite. These treatments are for various types of cancer, both solid tumours and blood cancers. The main goal is to understand the long-term effects of these special cell treatments. We want to find out more about their safety over time, how effective they continue to be in managing cancer, and how long their benefits might last. By carefully following up with participants, researchers hope to gain a better understanding of these innovative therapies, which could help improve future treatments for cancer patients.
At a glance
What is this study about?
This study is designed to keep track of people who have taken part in earlier research looking at new cell treatments for cancer. You might have heard of these as 'gene-modified cells' or 'CAR T-cell therapies'. These are treatments where some of a patient's own immune cells are changed in a lab to better fight cancer, and then put back into the patient's body.
The main purpose of this follow-up study is to learn more about how these treatments work over many years. Researchers want to understand two key things: how safe these treatments are in the long run and how well they continue to control the cancer over time. This kind of information is really important because it helps doctors and scientists understand the full picture of these new therapies, not just what happens in the first few months or years.
By carefully watching the health of people who have had these treatments, we can learn valuable lessons that will help improve future cancer care. This study isn't about giving new treatment, but about gathering information from ongoing health checks to see how participants are doing after their initial therapy.
Key takeaways
- This study is for people who've had specific cell treatments for cancer in past Kite studies.
- It's about checking your long-term health and how well those treatments continue to work.
- No new treatments or medicines are given in this follow-up study.
- Your participation helps improve how we understand and use these advanced cancer therapies.
- You'll have regular appointments to monitor your well-being.
- You can stop taking part at any time without affecting your medical care.
Who may be eligible?
To be part of this study, you must have already taken part in a previous Kite-sponsored study where you received one of the special gene-modified cell treatments. You would have finished or stopped the regular follow-up from that first study.
It's very important that you understand what the study involves and are happy to sign a consent form. This form explains everything in detail. You also need to be willing and able to attend all the scheduled follow-up appointments and meet the study's requirements.
There are no specific reasons why someone would be excluded from this study, other than not meeting the points mentioned above.
Could this study suit you?
Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.
- Did you receive a gene-modified cell treatment in a previous Kite-sponsored study?
- Have you finished or completed the follow-up period from that first study?
- Are you able to understand and sign a consent form for this study?
- Are you willing and able to attend follow-up appointments when asked?
What does participation involve?
If you join this study, you won't be given any new medication or treatment. Instead, your participation will mainly involve attending follow-up appointments. These visits are important for monitoring your health and how you're doing after your original cell therapy.
During these appointments, the study team will carry out health checks and assessments, which might include things like blood tests or reviewing your medical history. The exact schedule and what happens at each visit will be explained to you thoroughly before you agree to take part. The total duration of your participation will depend on the specific requirements for long-term monitoring, which can extend for several years after your initial treatment.
Potential risks and benefits
Locations (90)
- Banner MD Anderson Cancer CenterVerified postcodeGilbert, United States
- City of HopeVerified postcodeDuarte, United States
- UC San Diego Moores Cancer CenterVerified postcodeLa Jolla, United States
- Children's Hospital Los AngelesVerified postcodeLos Angeles, United States
- University of California Los AngelesVerified postcodeLos Angeles, United States
- Children's Hospital of Orange CountyVerified postcodeOrange, United States
- Stanford UniversityVerified postcodePalo Alto, United States
- University of California Davis Comprehensive Cancer CenterVerified postcodeSacramento, United States
- University of California, San Francisco Medical CenterVerified postcodeSan Francisco, United States
- Colorado Blood Cancer InstituteVerified postcodeDenver, United States
- Georgetown University Medical CenterVerified postcodeWashington D.C., United States
- Sylvester Comprehensive Cancer CentreVerified postcodeMiami, United States
Common questions
What is a 'gene-modified cell' treatment?
It's a special therapy where some of your own immune cells are changed in a lab to help them fight cancer better, and then put back into your body.
Will I receive new treatment in this study?
No, this study is about checking on your health after previous treatments. You won't be given any new medicines or therapies as part of this study.
Why is this long-term follow-up important?
It helps doctors learn about the long-term safety and effectiveness of these new cancer treatments, which can improve future care for other patients.
What kind of appointments will I have?
You'll have regular check-ups and assessments, which might include reviewing your health and taking blood samples, as explained by your doctor.
Can I stop participating if I change my mind?
Yes, you can choose to leave the study at any time, and it won't affect the medical care you get.
How to find out more
Always speak to your GP or specialist before deciding to take part in a study.
Interested in taking part?
Discussion
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