A Study to Evaluate the Safety of INCA33890 in Participants With Advanced or Metastatic Solid Tumors

To be considered for this study, you need to be at least 18 years old and have a confirmed diagnosis of an advanced or spreading solid cancer. For some parts of the study, you must have already tried other cancer treatments that didn't work or weren't right for you. Your general health and ability to do daily activities should also be good, which doctors measure using a score called ECOG performance status.

You would also need to be willing to have a small tissue sample (biopsy) taken from your tumour before and during the treatment, as this helps researchers understand how the medicine is working. Your cancer should also be measurable on scans so doctors can track any changes.

However, there are reasons you might not be able to join. For example, if you have other cancers that are active, unmanaged heart problems, recent serious infections, uncontrolled autoimmune diseases needing strong medication, or if your brain or spinal cord cancer has spread or is untreated. Also, if you've had an organ transplant, have certain infectious diseases like active hepatitis or HIV, or are on high doses of steroids, you might not be eligible.

If you join this study, you will receive the investigational medicine INCA33890, possibly along with other standard cancer treatments. This will involve regular visits to the hospital or clinic for treatment, blood tests, and scans to monitor your health and how the medicine is affecting your cancer. Researchers will pay close attention to any side effects you might experience.

You will also need to have biopsies taken from your tumour at certain times during the study. These are small procedures where doctors remove a tiny piece of tissue for analysis. The total length of your participation will depend on how you respond to the treatment and the study plan, but you will be closely monitored throughout.