Multivessel Balloon Occlusion to Investigate Obstructive Coronary Artery Disease and aNgina

To join this study, you would need to have chest pain (angina) that doctors think could be helped by a procedure to open up your heart arteries (a PCI or stenting). You'd also need to have clear evidence from scans or other tests that you have significant narrowing in two or more of your heart arteries that are at least 2.5mm wide.

There are some reasons why you might not be able to take part. For example, if you've recently had a heart attack, if you've previously had major heart bypass surgery, if you have severe narrowing in a very important main heart artery, or if you have a completely blocked artery that can't be easily opened. Other reasons might include severe problems with your heart valves, very weak heart pump function, or if you can't have the PCI procedure or are allergic to certain medications used during the procedure, like antiplatelet drugs or adenosine. Pregnant individuals are also not able to participate.

If you decide to take part in this study, you will undergo a procedure where doctors treat your heart arteries. During this procedure (which is similar to putting in a stent), they will carefully assess each narrowed artery one by one. This involves temporarily and safely blocking individual narrowed arteries and monitoring any symptoms you might experience. This part of the study will involve careful observation to see how each blockage contributes to your angina.

After the procedure, you will likely have regular check-ups and assessments to monitor your health and symptoms. The full duration of your participation, including follow-up appointments, will be clearly explained by the study team. You will be given full details about any medications you need to take before, during, and after the procedure.