RecruitingPHASE4INTERVENTIONAL

Staphylococcus Aureus Network Adaptive Platform Trial

The SNAP trial is looking into better ways to treat a serious blood infection caused by a germ called Staphylococcus aureus (S. aureus), also known as SAB. This infection can be very dangerous, and sadly, some people don't survive. Doctors currently use different ways to treat it, but aren't sure which is most effective. This study will test several existing treatments to see which ones save the most lives within 90 days. Unlike traditional studies, SNAP can change as it goes along, focusing more on treatments that seem to work better and removing those that don't. This helps ensure patients receive the most promising care and helps doctors quickly learn the best ways to treat this infection.

At a glance

Status

Recruiting

Phase

PHASE4

Sponsor

University of Melbourne

Enrolment target

8,000

Start

16 Feb 2022

Estimated completion

01 Dec 2028

Staphylococcus Aureus Bacteremia

What is this study about?

The Staphylococcus aureus Network Adaptive Platform (SNAP) trial is a really important study looking for better ways to treat a serious blood infection. This infection is caused by a germ called Staphylococcus aureus, which doctors often shorten to S. aureus or SAB. When S. aureus gets into your bloodstream, it can be very dangerous and can lead to serious health problems, and sadly, some patients don't survive.

Currently, there are several ways doctors treat S. aureus blood infections, but they don't have a clear idea of which treatment plan is the best. The SNAP trial wants to change that. It's designed to compare different treatments to find out which ones lead to the best results, specifically looking at which treatments help the most patients survive the first 90 days after getting the infection.

What's special about the SNAP trial is that it's 'adaptive.' This means that as the study goes on and doctors learn more about which treatments are working better, they can adjust the trial. They can give more patients the treatments that seem more effective and stop using treatments that aren't working as well. They can also add new treatments if they look promising. This smart approach helps ensure that patients in the trial get the best possible care based on the latest information, and it helps doctors quickly figure out the most effective ways to fight this infection.

Key takeaways

The SNAP trial studies treatments for a serious blood infection (S. aureus).
It aims to find the best treatments to improve survival.
The study is 'adaptive', meaning it learns and adjusts as it goes.
All treatments are existing medicines, not experimental ones.
Participation could help uncover better future treatments for this infection.

Who may be eligible?

To join the main part of this study, you would need to have a Staphylococcus aureus germ found in at least one of your blood tests. You also need to be a patient in a hospital taking part in the study. If you've sadly passed away, but were in a participating hospital when your blood sample was taken, your medical information might still be included in the study.

However, there are reasons why you might not be able to join. For example, if it's been more than 72 hours (3 days) since your blood test was taken, or if other germs are found in your blood at the same time as S. aureus. You also can't join if you've already been part of this specific trial before, or if your medical team feels that joining wouldn't be in your best interest due to other serious health concerns or if you are receiving end-of-life care. Patients under 18 years old can only join if the hospital has special approval for younger patients.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Do you have Staphylococcus aureus found in your blood?
Are you currently an inpatient at a hospital participating in this study?
Is it less than 3 days since your blood sample was taken?
Do you have only S. aureus in your blood, and no other serious infections there?
Are you aged 18 or over (unless your hospital has approval for younger patients)?

Answer every question to see your result.

What does participation involve?

If you are asked to join the SNAP trial, you'll be assigned by chance to one of the different treatment groups. These treatments are all ones that doctors already use. You'll receive your antibiotics, likely through an drip into your vein while you're in the hospital. The study team will closely monitor your health and recovery while you are receiving treatment and thereafter. They will review your medical information to see how well the treatment is working. The SNAP trial aims to find the most effective treatments for S. aureus blood infections to improve patient outcomes.

Potential risks and benefits

Taking part in this study could help doctors learn which treatments for S. aureus blood infections are most effective, potentially helping you and many future patients. All treatments used are already part of standard medical care, so you wouldn't be receiving an experimental drug. However, as with any medical treatment, there can be side effects, and your doctor will discuss these with you. You are free to withdraw from the study at any time without it affecting your medical care.

Locations (161)

Some site locations are approximate. We're improving this — please verify with the trial team before travelling.

Houston Methodist Research Institute
Verified postcode
Houston, United States· Recruiting
Canberra Hospital
Verified postcode
Garran, Australia· Recruiting
Blacktown Hospital
Verified postcode
Blacktown, Australia· Recruiting
Royal Prince Alfred Hospital
Verified postcode
Camperdown, Australia· Recruiting
Concord Repatriation and General Hospital
Verified postcode
Concord, Australia· Recruiting
St Vincent's Hospital Sydney
Verified postcode
Darlinghurst, Australia· Recruiting
Nepean Hospital
Verified postcode
Kingswood, Australia· Recruiting
St George Hospital
Verified postcode
Kogarah, Australia· Not yet recruiting
Liverpool Hospital
Verified postcode
Liverpool, Australia· Recruiting
John Hunter Hospital
Verified postcode
New Lambton Heights, Australia· Recruiting
John Hunter Children's Hospital
Verified postcode
Newcastle, Australia· Recruiting
Orange Health Service
Verified postcode
Orange, Australia· Recruiting

Common questions

What is Staphylococcus aureus (S. aureus) blood infection?

It's a serious infection where a common germ called Staphylococcus aureus gets into your bloodstream. It can make you very unwell.

What does 'adaptive platform trial' mean?

It's a smart study design that can change as it goes along. Doctors can learn from early results and focus more on treatments that are working best, or remove those that aren't.

Will I get a new or experimental medicine?

No, all the treatments being tested in this study are medicines already used by doctors. The study is comparing them to find out which works best.

How long will I be in the study?

The study will look at how you are doing for 90 days after your infection. Your medical team will monitor you during this time.

Can I choose my treatment?

No, if you join, you will be randomly assigned to one of the established treatment options. This helps ensure fair testing of each treatment.

How to find out more

Lauren Barina

lauren.barina@unimelb.edu.au +61 (03) 8344 1623 Official trial record

Always speak to your GP or specialist before deciding to take part in a study.