A Study to Test the Safety and Tolerability of Staccato Alprazolam in Study Participants 12 Years of Age and Older With Stereotypical Prolonged Seizures

To join this study, you must be at least 12 years old. You'll also need to have an adult caregiver, aged 18 or over, who can recognise and observe your seizures. This caregiver will be an important part of your support during the study.

Participants must have been diagnosed with epilepsy (either focal, generalised, or both) and have a clear history of prolonged seizures that follow a typical pattern. These prolonged seizures must meet specific criteria regarding their length and type. A very important condition for joining this study is that you must have already taken Staccato alprazolam as part of a previous clinical trial.

You cannot join if you have struggled with alcohol or drug use in the past year, or if you are allergic to any part of the study medicine or similar drugs, including certain asthma medicines. You also can't participate if you've had a severe generalised seizure (called convulsive status epilepticus) in the 8 weeks before checking for the study, or if you have seizures that aren't epilepsy-related but look very similar to your epileptic seizures. Finally, if you have severe asthma or a serious sensitivity to things like pollen or animals that cause breathing problems, you would not be able to join.

If you decide to take part, the researchers will check your health carefully. You'll continue to use Staccato alprazolam, which you've already used in a past study. The study team will regularly monitor your health, how often your seizures happen, and any side effects you might experience. This will involve regular visits to the study clinic for assessments. The exact number of visits, what happens at each visit, and the total length of your participation will be explained in detail by the study team, as it can vary.