Cryoablation for Monomorphic Ventricular Tachycardia

To be considered for this study, you need to be at least 18 years old. You must have scarring in your heart muscle that is causing recurrent, bothersome episodes of a specific type of fast heart rhythm called monomorphic ventricular tachycardia (VT). This heart scarring can be due to a previous heart attack or other heart problems, and doctors would typically recommend an ablation procedure for your condition.

You also need to have an Implantable Cardioverter Defibrillator (ICD) already fitted, which helps manage dangerous heart rhythms. Furthermore, you should have experienced at least one episode of this specific VT in the last six months and either found that your current medications aren't working well enough, or you can't tolerate their side effects. The study also needs you to be able and willing to attend all scheduled appointments and give your informed consent.

There are some conditions that would prevent you from joining. These include having a blood clot in your heart, having VT caused by reasons other than scarring (like very specific types of fast heartbeats or problems with your body's chemistry), or if your VT problem is only on the outer surface of your heart. Specific types of VT that aren't caused by scar tissue or are linked to other conditions like electrolyte imbalances would also mean you couldn't take part.

If you decide to take part in this study, you will undergo a cryoablation procedure using the Adagio VT Cryoablation System. Before and after the procedure, you will have several appointments where the study team will monitor your health, heart rhythm, and the effectiveness of the treatment. These appointments will involve check-ups and possibly some tests to see how you are responding to the procedure and to look for any side effects. The study has two phases, an initial safety check and then a larger phase to gather more information, meaning your follow-up will continue for a certain period to track your progress. The total duration of your participation, including all follow-up visits, will be explained in detail by the study team, but it will last for a sustained period to collect all necessary safety and effectiveness data. You won't be expected to take any new study medications, as the focus is on the cryoablation procedure itself.