A Study Evaluating the Efficacy and Safety of Afimetoran Compared With Placebo in Participants With Active Systemic Lupus Erythematosus (SLE)

To be part of this study, you would generally need to be between 18 and 70 years old. You must have been diagnosed with lupus at least 12 weeks before checking your suitability for the study, and your diagnosis needs to meet specific criteria for lupus.

You would also need to have positive results for certain blood tests related to lupus, which show that your immune system is overactive. Additionally, your lupus symptoms should currently be active, particularly affecting your joints or causing skin rashes. This activity will be measured using a specific scoring system.

However, some conditions would mean you couldn't join. For example, if you have severe kidney problems caused by lupus, or active severe brain or nerve problems from lupus, you wouldn't be eligible. Also, if you have another condition called Mixed Connective Tissue Disease where lupus isn't the main problem, or a condition called Antiphospholipid Syndrome, you wouldn't be able to participate. The study team will check other specific rules too.

If you decide to take part, you would receive either the study medicine, Afimetoran, or a placebo (a dummy pill). You wouldn't know which one you're getting, and neither would your study doctor, until the end of that part of the study. You would need to attend regular appointments at the study clinic. These visits would include physical examinations, blood and urine tests, and answering questions about your health and any symptoms you're experiencing. You would also need to take the study medication as instructed. The total time you'd be involved in the study and receiving treatment would be explained to you in detail by the study team.