RecruitingNAINTERVENTIONAL

Is There a Genetic Predisposition for Acute Stress-induced (Takotsubo) Cardiomyopathy

This study aims to discover if certain genes make people more likely to develop 'broken heart syndrome,' also known as Takotsubo cardiomyopathy. This condition can feel like a heart attack and is often triggered by intense emotional or physical stress. Researchers are collecting blood samples from people diagnosed with this condition to look for specific genetic patterns. Understanding these genetic links could help us learn more about why some people get this syndrome and could also be important for their family members. This work is crucial for improving our understanding of this often serious heart condition.

At a glance

Status

Recruiting

Phase

Sponsor

University of Aberdeen

Enrolment target

700

Start

12 Mar 2019

Estimated completion

31 Dec 2028

Takotsubo Cardiomyopathy

What is this study about?

Imagine feeling a sudden, intense chest pain, much like a heart attack, but it turns out your heart is temporarily weakened, often after a very stressful event. This condition is called Takotsubo cardiomyopathy, or 'broken heart syndrome.' While it's serious and can have lasting effects, the good news is that the heart usually recovers over time. However, we don't fully understand why some people get it and others don't, especially when faced with similar stressors.

This study is trying to answer a very important question: Is there a genetic link? In other words, do certain genes make some people more prone to developing 'broken heart syndrome' when under extreme stress? By looking at the genes of people who have experienced this condition, researchers hope to find common patterns or specific genes that might increase someone's risk. They believe that if we understand these genetic connections, it could help explain why the condition develops.

Ultimately, the goal is to improve our overall understanding of this complex heart condition. By identifying potential genetic factors, it could lead to new ways of thinking about prevention or even treatment in the future. This research could also have implications for family members, helping them understand if they might share a similar predisposition.

Key takeaways

This study explores if genetics play a role in 'broken heart syndrome' (Takotsubo cardiomyopathy).
It involves a simple blood test for genetic analysis.
Participation helps scientists understand why some people are more vulnerable to this stress-related heart condition.
All adults diagnosed with Takotsubo cardiomyopathy, especially in Scotland from 2010 onwards, are invited.
No new medications, extra visits, or direct personal treatment benefits are involved.
Your privacy and right to withdraw are fully protected.

Who may be eligible?

You might be able to take part in this study if you have been diagnosed with Takotsubo cardiomyopathy, also known as 'broken heart syndrome'.

The study is primarily looking for people in Scotland who received this diagnosis any time from 2010 onwards. However, if you live elsewhere in the world and have close family members who have also been diagnosed with Takotsubo cardiomyopathy (these are called 'familial cases'), you might also be eligible to participate.

There are not many restrictions on who can take part, as long as you meet the diagnosis criteria and are willing to participate. Importantly, adults of any age and all sexes are welcome to join.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

I have been diagnosed with Takotsubo cardiomyopathy (broken heart syndrome).
My diagnosis was made in Scotland between 2010 and now (if applicable).
I'm willing to provide a blood sample.
I am aged 18 or over.

Answer every question to see your result.

What does participation involve?

If you decide to take part in this study, it's quite straightforward. The main thing involved is providing a blood sample. This sample will be used for what's called 'genetic analysis,' which means scientists will look at your DNA to identify any specific genetic patterns associated with Takotsubo cardiomyopathy. There will be no need for hospital stays, taking new medications, or repeat visits for this study. It's a one-off involvement focusing solely on collecting your blood for analysis.

Potential risks and benefits

Taking part in this study could help us all better understand 'broken heart syndrome' and why some people get it. While there isn't a direct personal benefit to you, your contribution could lead to important discoveries that might help others and their families in the future. The risks of providing a blood sample are generally very low, similar to those of a routine blood test, such as a small bruise or slight discomfort. You are completely free to change your mind and withdraw from the study at any time without giving a reason, and this will not affect any medical care you receive.

Locations (2)

Some site locations are approximate. We're improving this — please verify with the trial team before travelling.

Cardiac Research Office, Aberdeen Royal Infirmary
Verified postcode
Aberdeen, United Kingdom· Recruiting
Cardiovascular Research Facility
Verified postcode
Aberdeen, United Kingdom· Recruiting

Common questions

What is 'broken heart syndrome'?

It's a temporary heart condition, often triggered by severe emotional or physical stress, that can feel like a heart attack but usually resolves itself.

Why is this study important?

It aims to find out if there's a genetic reason why some people develop 'broken heart syndrome,' which could help us understand and potentially treat it better.

What do I have to do if I take part?

You'll provide a single blood sample for genetic testing. That's essentially all that's involved.

Will I get results from my genetic test?

The study aims to understand patterns across many people, not to provide individual results. You won't receive personal genetic test results.

Is my information kept private?

Yes, all your personal and medical information will be kept strictly confidential according to research guidelines.

How to find out more

Amelia E Rudd, MSc

a.e.rudd@abdn.ac.uk 01224559473 Official trial record

Always speak to your GP or specialist before deciding to take part in a study.