AuthorisedTherapeutic use (Phase IV)Interventional

ASSESSMENT OF THE EFFICACY IN REDUCING EDEMA, TRISMUS AND PAIN, OF DEXAMETHASONE ACCORDING TO DIFFERENT INTRAORAL AND EXTRAORAL PREOPERATIVE APPLICATION ROUTES, IN THE SURGERY OF RETAINED LOWER THIRD MOLARS.

This study is investigating the best way to give a medicine called dexamethasone to people who are having their wisdom teeth removed. When wisdom teeth are taken out, it can sometimes cause swelling, make it hard to open your mouth (jaw stiffness), and lead to pain. Dexamethasone is a type of steroid medicine that can help reduce these issues. Researchers are comparing different methods of giving this medicine before surgery to see which one works best. This is an important step to help improve comfort and recovery for patients. The study is open to adults aged 18 and over, and they will be followed for one year after their surgery to see the long-term effects.

At a glance

Status

Authorised

Phase

Therapeutic use (Phase IV)

Sponsor

Complutense University Of Madrid

Enrolment target

Start

14 Mar 2025

Third molar extraction

What is this study about?

When you have your wisdom teeth removed, it's common to experience some swelling, pain, and difficulty opening your mouth widely afterwards. Doctors often use medicines to help manage these side effects and make your recovery more comfortable.

This study is focusing on a specific medicine called dexamethasone. This is a type of steroid that's known for reducing swelling and discomfort. What the researchers want to find out is whether giving this medicine in different ways just before your surgery makes any difference to how well it works. For example, they might be looking at giving it as a tablet, or as an injection in different places, to see if one method is better at preventing swelling, jaw stiffness, and pain.

The main goal of this research is to improve the experience for people having wisdom tooth surgery. By understanding the best way to give dexamethasone, healthcare professionals can make sure patients have the smoothest and most comfortable recovery possible. This type of study is important because it helps doctors choose the most effective treatments for their patients.

Key takeaways

The study investigates the best way to give dexamethasone for wisdom tooth surgery.
It aims to reduce swelling, jaw stiffness, and pain after tooth removal.
Participants will be adults having their wisdom teeth out.
The study involves a one-year follow-up after surgery.
It's about making recovery from wisdom tooth surgery more comfortable.

Who may be eligible?

This study is for adults who are planning to have their wisdom teeth removed. To take part, you need to be at least 18 years old. There isn't an upper age limit, so people of any adult age can join if they meet the other requirements.

Both men and women can participate in this research. The study is specifically for individuals who are having wisdom teeth surgery. If you're having other dental procedures or are not an adult, this study wouldn't be suitable for you.

Further details about specific health conditions or medications you might be taking would be discussed by the study team to make sure it's safe for you to participate.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you 18 years old or older?
Are you planning to have your wisdom teeth removed?
Are you comfortable with a one-year follow-up period?
Are you open to trying different ways of receiving medication before surgery?

Answer every question to see your result.

What does participation involve?

If you decide to take part in this study, you would receive the medicine called dexamethasone before your wisdom tooth surgery. The study team will explain exactly how it will be given to you, as this is what they are studying – comparing different ways of giving the medicine.

After your surgery, the research team will monitor your recovery. This will involve regular check-ups to see how your swelling, jaw movement, and pain are progressing. These assessments will happen over a period of one year. The study team will explain how many appointments you'll need and what will happen at each one.

Potential risks and benefits

Taking part in this study may offer potential benefits, such as receiving treatment that could help reduce swelling, pain, and jaw stiffness after wisdom tooth surgery. While dexamethasone is a commonly used medicine, like all medications, it can have side effects. The study team will explain any known or potential risks associated with the different ways the medicine is given. You have the right to withdraw from the study at any time, for any reason, without it affecting your medical care.

Locations (1)

Some site locations are approximate. We're improving this — please verify with the trial team before travelling.

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Unverified
Spain

Common questions

What is dexamethasone?

Dexamethasone is a medicine that helps reduce swelling and discomfort. It's a type of steroid often used after surgery.

Why are you studying this medicine?

We are studying different ways to give dexamethasone before wisdom tooth surgery to find out which method works best at reducing swelling, jaw stiffness, and pain.

Will I know how I'm getting the medicine?

The study team will explain all aspects of the study, including how the medicine will be given to you, before you agree to take part.

How long will I be involved in the study?

You'll be followed for one year after your wisdom tooth surgery to track your recovery and see the long-term effects of the treatment.

What happens if I don't want to continue in the study?

You are free to leave the study at any time, for any reason, without it affecting your usual dental care.