RecruitingNAINTERVENTIONAL

Exercise Training and Endothelial Function in Type 1 Diabetes

This research is investigating whether exercise can improve blood vessel health in adults with Type 1 diabetes (T1D). Many people with T1D can experience problems with their blood vessels early on, even before they notice any symptoms. This study aims to find out if a non-drug approach, like exercise, can help prevent or improve these issues. We're looking at how exercise affects both large and small blood vessels, and how it might impact the body's energy use and brain health. We hope to show that exercise can offer a simple, natural way to support blood vessel function and overall health for people living with Type 1 diabetes.

At a glance

Status

Recruiting

Phase

Sponsor

University Hospital, Lille

Enrolment target

Start

12 Nov 2019

Estimated completion

01 Nov 2028

Type1diabetes

What is this study about?

This study is called 'Exercise Training and Endothelial Function in Type 1 Diabetes.' It's looking at how exercise might help the blood vessels in people who have Type 1 diabetes. Think of your blood vessels like tiny pipes that carry blood all around your body. In people with Type 1 diabetes, these pipes can sometimes start to show problems early on, even before they cause any noticeable symptoms. This is what we call 'endothelial dysfunction' – it simply means the inner lining of these blood vessels isn't working as well as it should. The researchers want to find natural ways, besides medication, to keep these blood vessels healthy.

The main goal of this particular study is to see if regular exercise can make a positive difference to how these blood vessels work in adults with Type 1 diabetes. The participants in this study are adults who have Type 1 diabetes but haven't yet developed any of the common complications associated with it, like kidney problems or eye damage. The researchers believe that exercise could be a safe and effective way to protect blood vessel health.

They will also be looking at other things, such as how exercise affects smaller blood vessels, larger blood vessels, and how well blood flows to your tissues during exercise. They're also interested in how exercise might impact your body's energy use and brain health. Researchers expect that this exercise programme will improve how blood vessels work, especially the inner lining, and also improve how the body uses energy. This could be a really important step in finding simple, everyday ways to help people with Type 1 diabetes stay healthier for longer.

Key takeaways

Looks at how exercise affects blood vessels in Type 1 diabetes.
Focuses on adults aged 18-50 without diabetes complications.
Aims for a non-drug way to improve health.
May involve an exercise programme vs. usual activity.
Could help us understand how to prevent diabetes complications.
You can withdraw from the study at any time.

Who may be eligible?

This study is looking for adults aged between 18 and 50 years old who have Type 1 diabetes. To be included, you must have been diagnosed with Type 1 diabetes for at least one year and, importantly, you must not have any signs of existing diabetes-related complications, such as problems with your eyes, kidneys, or nerves. You also need to be covered by social security.

There are several reasons why someone might not be able to join the study. For example, if you've been diagnosed with Type 1 diabetes for less than a year, or if you have other types of diabetes like Type 2. You also can't take part if you already have diabetes-related complications, if you are a smoker, or if you have high blood pressure. They are also unable to include people who are very overweight (with a Body Mass Index over 30), or if you have other chronic health conditions (apart from Type 1 diabetes itself). If you have any ongoing pain that makes it difficult to move your body, or if you've had a head injury in the past, you also won't be able to participate. This is to make sure the study focuses on the effects of exercise in a specific group of people.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you between 18 and 50 years old?
Have you had Type 1 diabetes for at least one year?
Do you *not* have any diabetes complications like eye, kidney, or nerve problems?
Are you a non-smoker?
Do you *not* have high blood pressure, and are you *not* very overweight (BMI over 30)?

Answer every question to see your result.

What does participation involve?

The detailed information about what taking part involves isn't provided in the summary. However, in studies like this, participants are usually divided into different groups by chance (like flipping a coin). One group might follow an exercise training programme, while another might continue with their usual daily activities. You would likely have a series of appointments, which could include some health checks, blood tests, and tests to see how your blood vessels are working, both before and after the exercise period. The length of the exercise programme and the total duration of your involvement in the study would be clearly explained by the research team.

Potential risks and benefits

Taking part in a study like this could offer potential benefits, such as improving your understanding of how exercise affects your body and potentially improving your blood vessel health. However, as with any exercise program, there are potential risks, such as muscle soreness or minor injuries, though these would likely be managed and supervised. All medical tests also carry a very small risk, which the research team will explain. You are always free to change your mind and withdraw from the study at any time, for any reason, without it affecting your medical care.

Locations (1)

Hop Claude Huriez Chu Lille
Verified postcode
Lille, France· Recruiting

Common questions

What is 'endothelial function'?

Endothelial function means how well the inner lining of your blood vessels works. It's important for keeping your blood vessels healthy.

Why are you studying exercise for Type 1 diabetes?

We want to see if exercise can be a natural way to help protect blood vessel health in people with Type 1 diabetes, potentially preventing future complications.

Do I need to be a super fit athlete to join?

The information doesn't say you need to be an athlete, but generally, exercise studies want people who are able to exercise safely.

Will I have to take new medicine in this study?

This study is focused on 'non-pharmacological interventions,' which means we are looking at treatments like exercise, not new medications.

What does 'non-pharmacological' mean?

It simply means treatments that don't involve medicines, like exercise or changes to your diet.

How to find out more

Anne Vambergue, MD,PhD

anne.vambergue@chu-lille.fr 320444184 Official trial record

Always speak to your GP or specialist before deciding to take part in a study.