PREdicting Failure of Non-inVasIve Ventilatory Support Using Non-invaSIve mONitoring in Non-intubated Patients With Acute Hypoxemic Respiratory Failure or Post-extubation Failure. The PREVISION Study
This study, called PREVISION, aims to find better ways to tell if patients using breathing support like High Flow Nasal Cannulas (HFNC) or Non-Invasive Ventilation (NIV) might be at risk of their treatment not working. It focuses on patients who have trouble breathing due to lung issues, or who are struggling after having a breathing tube removed. Researchers will use gentle, non-invasive tools, like special skin patches and ultrasound, to look at how a patient’s lungs are working and how their breathing muscles are moving. The main goal is to see if these simple measurements can help doctors predict problems early, so they can adjust treatments and improve care without causing any discomfort to the patient.
At a glance
What is this study about?
When people have serious breathing problems, doctors sometimes use special machines to help them breathe without needing a tube down their throat. Two common ways to do this are called High Flow Nasal Cannula (HFNC) and Non-Invasive Ventilation (NIV). These treatments deliver oxygen and air through a mask or tubes placed in the nose.
However, sometimes these treatments don't work as well as expected, and doctors might need to try something else. This study, called PREVISION, is trying to find better ways to spot early signs that HFNC or NIV might not be enough. The researchers want to see if specific, harmless measurements of how your lungs and breathing muscles are working can help predict if you're at risk of needing more help with your breathing.
The main question they want to answer is whether unusual patterns in how air moves in your lungs can tell us if these breathing supports might fail. This could help doctors make quicker and better decisions to ensure patients get the right breathing support at the right time, potentially preventing more serious problems.
Key takeaways
- This study helps improve breathing support for patients.
- It uses painless, non-invasive tests like a chest belt and ultrasound.
- The study aims to predict if current breathing support might fail early.
- Participation involves a single 30-minute session.
- Your involvement could help many future patients.
- You can withdraw at any time without affecting your care.
Who may be eligible?
To be able to take part in this study, you need to be at least 18 years old. You also need to be currently using a breathing support called Non-Invasive Ventilation (NIV) or High Flow Nasal Cannula (HFNC) while you are in the hospital.
However, there are some reasons why you wouldn't be able to join. For example, if you have a long-term problem where your body holds onto too much carbon dioxide, or if you have a nerve or muscle condition that affects your breathing, you wouldn't be eligible. Also, if you use NIV at home regularly, or if you have a breathing tube (tracheostomy), you can't join.
Finally, if you have a heart pacemaker or defibrillator, or if you have burns on your chest where a special sensing belt would need to go, you wouldn't be able to participate. This is because the study uses a gentle device that measures electrical signals, and these conditions could interfere with it.
Could this study suit you?
Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.
- Are you 18 years old or older?
- Are you currently using HFNC or NIV in the hospital?
- Do you *not* have a pacemaker or defibrillator?
- Do you *not* have burns on your chest?
- Do you *not* have certain long-term breathing or muscle conditions?
What does participation involve?
If you agree to take part, the study will involve one session which will last about 30 minutes. During this time, while you are using your usual breathing support (HFNC or NIV), a special soft belt will be placed around your chest. This belt measures how air moves in your lungs, but it doesn't cause any pain or use radiation. The researchers will record information from this belt for about 5 to 10 minutes.
They will also use a small ultrasound device, like those used for checking babies during pregnancy, to look at your breathing muscles in your chest and tummy. This is also painless. The study team will also note down details about your current breathing support settings, some general health information, and how breathless you are feeling. There are no extra visits or medications involved, and you'll be followed up for 7 days to see how your breathing support is working.
Potential risks and benefits
Locations (1)
- St. Michael's HospitalVerified postcodeToronto, Canada· Recruiting
Common questions
What is the main goal of this study?
The study aims to find new ways to predict if breathing support like HFNC or NIV might not be working, using simple, harmless tests.
Will taking part involve any pain or radiation?
No, the tests are completely painless and do not use any radiation. A soft belt around your chest and a gentle ultrasound are used.
How long will the study take?
The measurement part of the study will only take about 30 minutes in total, all done in one session.
Will I have to take any new medicines?
No, there are no new medicines involved in this study. You will continue with your usual medical care.
Can I stop participating if I change my mind?
Yes, you can withdraw from the study at any point without needing a reason, and your medical care will not be affected.
How to find out more
Always speak to your GP or specialist before deciding to take part in a study.
Interested in taking part?
Discussion
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