A Study of Bleeding and Treatment in Participants With Von Willebrand Disease

To join this study, you need to be between 16 and 69 years old and have been diagnosed with Type 1 or Type 2A Von Willebrand Disease. Your diagnosis must be confirmed by specific blood test results, showing low levels of the von Willebrand factor and another clotting factor called FVIII.

It's important that you experience some bleeding symptoms related to your VWD. This could mean you've had bruising or bleeding that needed treatment at least three times a year, or you regularly experience heavy menstrual bleeding.

There are also some reasons why you might not be able to join. For example, if you have a history of serious allergic reactions to certain medications, a personal history of blood clots (unless it was a mild, catheter-related clot), or if you have other serious bleeding disorders or conditions that significantly increase your risk of blood clots. If you're planning major surgery during the study period or are already on continuous medication to prevent bleeding, you also wouldn't be able to participate.

If you decide to take part, you'll first have a screening visit to check if you're suitable for the study. Then, there will be a baseline evaluation where more information about your VWD will be collected. You'll then enter an observation period lasting about 4 months.

During this 4-month period, you'll have check-ins every two weeks, likely done remotely (like a phone or video call). In these check-ins, you'll discuss entries you've made in a bleed diary, where you'll record any bleeding episodes and what treatments you used. After the initial 4 months, you'll have the option to continue in the study for a longer observation period, up to a total of 12 months.