- recruitingTherapeutic confirmatory (Phase III)
Impact of a treatment with angiotensin receptor blocker on outcome after acute kidney injury in patients discharged from the ICU “START-or-NOT” trial. A prospective, randomized, double blinded, multicenter study
This clinical trial looks at whether a common blood pressure medicine called irbesartan can protect people who had sudden kidney problems during an intensive care stay. Researchers want to see if taking this daily tablet lowers the risk of heart attacks, strokes, and long-term kidney disease over the following year.
France - not yet recruiting
Treatment Costs of Kidney Injury in Patients Having Heart Surgery in the UK
This study looks at how much it costs to treat kidney problems that can happen after heart surgery in the UK. Researchers compared costs for patients who developed kidney injury with those who didn't, using existing hospital records.
United Kingdom - recruitingTherapeutic exploratory (Phase II)
A randomized, multi-centric, placebo-controlled, participant and investigator-blinded study to evaluate the safety, tolerability and efficacy of TIN816 in adult patients at risk for acute kidney injury following cardiac surgery
This study is testing a new medicine, TIN816, for adults having heart surgery. It aims to see if TIN816 can protect kidneys from injury, which can sometimes happen after such operations. Researchers are checking how safe and effective the medicine is.
Spain · Germany · Czechia - recruitingPHASE2
LSALT Peptide for Prevention or Attenuation of Acute Kidney Injury (AKI) in Patients Undergoing On-Pump Cardiac Surgery
This study looks into a new treatment called LSALT peptide to help prevent or reduce kidney damage in people having heart surgery. It compares LSALT with a dummy treatment to see if it's safe and effective.
Canada · Turkey (Türkiye) - recruiting
Association Between Renal Regional Oxygen Saturation Measured by Near-InfraRed Spectroscopy and Postoperative Renal Failure After Lung Transplantation Surgery: A Pilot Study
This study aims to see if a special monitor, using light, can help doctors predict kidney problems after lung transplants. It measures kidney oxygen levels during surgery, hoping to prevent serious kidney damage.
France - recruiting
Hamburg Acute Renal Injury Study (HARIS)
The HARIS study in Hamburg looks at kidney injury in hospital patients. It aims to understand why some people get kidney damage, how it develops, and what happens afterwards. This research could help doctors better predict, treat, and prevent long-term problems from kidney injury.
Germany - recruiting
Nephroprotective Measures in Critically Ill Patients With Moderate/Severe Acute Kidney Injury
This study looks at how well recommended kidney-protecting steps are used in very unwell hospital patients who have developed moderate to severe acute kidney injury (AKI). We want to see if these steps help improve their kidney health and overall recovery.
Austria · Germany · Netherlands - recruitingNA
Non-invasive Measurement of the Hypotension Prediction Index for the Reduction of Intraoperative Hypotension
This study is looking at a new way to prevent low blood pressure during major surgery. It uses a non-invasive device to predict low blood pressure before it happens, hoping to reduce complications like kidney and heart problems after surgery.
Germany - active not recruitingPHASE3
Does High-dose Vitamin B3 Supplementation Prevent Major Adverse Kidney Events During Septic Shock?
This study is testing if a high dose of vitamin B3 (Nicotinamide) can help prevent kidney problems in very sick patients with an infection called septic shock. We want to see if it reduces serious kidney issues within 30 days.
France - recruiting
The Rhabdomyolysis Evaluation in the Emergency Department (REED) Score
This study looks at older adults (60+) who fall and stay on the floor for a long time. It aims to create a tool to predict who might get a serious muscle breakdown condition called rhabdomyolysis and need hospital care, helping doctors decide who can safely go home.
United Kingdom - active not recruiting
A Study to Support the Development of the Enhanced Fluid Assessment Tool for Patients With Acute Kidney Injury
This study aims to create a better tool for doctors and nurses to check fluid levels in hospital patients with sudden kidney problems (AKI). Currently, it's hard to tell if patients have too much or too little fluid. This new tool could help them get the right care.
United Kingdom - active not recruitingNA
Urine Alkalinisation in COVID-19
This study looks at whether a simple treatment called sodium bicarbonate can protect the kidneys of very sick COVID-19 patients. We know kidney problems are common with severe COVID-19. This research wants to see if making blood less acidic might help prevent this serious issue.
United Kingdom - recruiting
MEMRI and Kidney Disease
This study uses a special MRI scan to look at how kidney injury, kidney transplants, and other kidney problems affect your heart. Researchers want to find a new way to identify people at risk of heart problems and ongoing kidney disease, helping them get treatment earlier.
United Kingdom - recruitingNA
Remote Ischemic Preconditioning in Septic Patients
This study looks at a simple method called Remote Ischemic Preconditioning (RIPC) in very ill patients with sepsis. It aims to see if this method, which involves briefly restricting blood flow to an arm, can help prevent or reduce kidney damage, a common problem in these patients.
Germany - not yet recruitingNA
The Effect of Standard vs. Shorter Filter Lifespan During Continuous Renal Replacement Therapy
This study looks at changing kidney filters more often for very ill patients with acute kidney injury. It wants to see if shorter filter use can lower the risk of new infections and if this can be done consistently.
Germany - recruitingPHASE2
Prevention of Nephrotoxin-Induced Acute Kidney Injury Using Cilastatin
This study looks at whether a medicine called cilastatin can stop kidney damage in hospital patients taking other strong medicines. Many common medicines can harm the kidneys, so researchers want to see if cilastatin can protect them. Participants will receive cilastatin or a dummy medicine.
Canada - recruitingPHASE3
Bleeding Reduction in Acute and Chronic Kidney Patients Having Surgery (BRACKETS) Pilot Trial
This study looks at two medicines, tranexamic acid and desmopressin, to see if they can reduce serious bleeding in people with kidney disease who are having surgery. It's a first step to see if a bigger study should be done.
Canada - recruiting
Cisplatin Induced Kidney Toxicity
This study looks for ways to predict and detect kidney damage caused by a cancer drug called Cisplatin. We'll examine blood and urine samples from children and adults with cancer to find early warning signs, aiming to improve treatment and protect kidneys.
Canada - recruitingNA
LoW Dose-Intensity vs. Standard Dose-Intensity COntinuous Renal ReplaceMent Therapy in Critically Ill Patients (WISDOM)
The WISDOM trial is looking into how much dialysis critically ill patients with severe kidney problems need. It compares the usual amount of dialysis with a lower amount to see if less is just as good, safer, and maybe even better for recovery and hospital costs.
United States · Canada · United Kingdom - recruitingNA
Pilot Study on HA380 Column Use in Critically Ill Patients Receiving Extracorporeal Support.
This study looks at a special blood filter, HA380, for very sick patients in intensive care. It's connected to machines like dialysis or ECMO to see if it can help them recover faster by reducing the body's overreaction to illness.
United Kingdom - authorisedTherapeutic confirmatory (Phase III)
Efficacy and tolerance of nicotinamide supplementation during acute kidney injury: a prospective randomized double-blind trial
This study is testing if a vitamin called nicotinamide can help people with sudden kidney problems (acute kidney injury) recover better. Researchers will give some patients nicotinamide and others a dummy pill to see if it improves their kidney function after 21 days.
France - recruiting
Improving Patient Assessment After Acute Kidney Injury (AKI)
This study aims to improve care for people after acute kidney injury (AKI). It looks at better ways to measure kidney function and understands patients' experiences to suggest new ways to support them. Participants may have blood tests, body scans, and interviews.
United Kingdom - recruitingNA
The Effect of Vasopressor Therapy on Renal Perfusion in Septic Shock
This study looks at how different medicines, like vasopressin and angiotensin II, affect blood flow to the kidneys in very unwell patients with a serious infection called septic shock. We want to see if these medicines can help improve kidney function when it's failing.
United Kingdom - recruitingPHASE2
A Study to Investigate the Efficacy, Safety, and Tolerability of AZD4144in Participants With Sepsis-associated Acute Kidney Injury.
This study looks at a new medicine called AZD4144 for people who have kidney damage from a serious infection (sepsis). We want to see if it's safe and helps their kidneys work better than a dummy medicine.
United States · Argentina · Belgium