A Study to Investigate the Efficacy, Safety, and Tolerability of AZD4144in Participants With Sepsis-associated Acute Kidney Injury.

This study is looking for adults between 18 and 80 years old. You must be in a hospital's critical care unit (like an ICU) because of a serious infection, known as sepsis.

Crucially, your kidneys must have also been affected within three days of your sepsis starting. Doctors will check this based on your blood and urine tests. You’ll also need to be receiving certain medicines (like ‘vasopressors’) to help keep your blood pressure stable due to the sepsis. Your overall kidney health before getting sick will also be considered.

There are also specific medical details your doctors will need to check to make sure participating is safe and suitable for you. For example, your weight needs to be between 40kg and 125kg.

If you decide to take part, you'll first have some checks to make sure the study is right for you. If you qualify, you'll be randomly assigned to receive either the study medicine (AZD4144) or a dummy medicine (placebo). Neither you nor your study doctor will know which you are receiving.

This medicine will be given once a day through a drip while you are in hospital. During this time, the study team will closely monitor your safety daily, take regular blood and urine samples, and carry out other health checks. After you stop receiving the study medicine, you'll continue to be monitored while you're in hospital and for up to two follow-up visits after you’ve gone home. The total time you're involved in the study, including follow-up, will be determined by how long you're in hospital and when your follow-up visits are scheduled.