advanced/metastatic solid tumors research hub
4 indexed studies · 2 currently recruiting
- ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
A Phase 1, Open-label, Multicenter Study of the Safety, Pharmacokinetics, and Pharmacodynamics of MK-4464 as Monotherapy and in Combination with Pembrolizumab in Participants with Advanced/Metastatic Solid Tumors
This early-stage study is testing a new medicine, MK-4464, alone and with another drug (pembrolizumab). It's for adults with advanced cancers to see if it's safe, how it moves through the body, and what effects it has. This is one of the first times it's being used in people.
Netherlands - recruitingPHASE1, PHASE2
A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors
This study is looking at a new drug called MCLA-158 for advanced cancers like bowel and head and neck cancer. It aims to find the safest dose and see how well it works alone or with other treatments. It's for patients whose cancer has spread or come back.
United States · Belgium · France - authorisedHuman Pharmacology (Phase I)- First administration to humans
A phase I/II trial of IOMX-0675 a fully human monoclonal antibody selectively inhibiting LILRB1/2 alone or in combination with pembrolizumab in patients with previously treated advanced/metastatic solid tumors (LIMNOS)
This study is testing a new drug (IOMX-0675) alone or with an existing treatment (Keytruda) for advanced cancers. The main goal is to find a safe and effective dose, and see how well it works and if it causes side effects.
Spain - recruitingPHASE1
A Study to Learn About the Study Medicine Called PF-08046876 in People With Advanced Solid Tumors
This study is looking at a new medicine called PF-08046876 for people with advanced cancers like bladder, lung, head & neck, oesophageal, or pancreatic cancer. It checks how safe the medicine is and how well it works. The medicine is given through a drip.
United States · Canada · Puerto Rico