A Study to Learn About the Study Medicine Called PF-08046876 in People With Advanced Solid Tumors

To be able to join this study, there are certain requirements you would need to meet. You must be at least 18 years old. You should have advanced cancer of the bladder, lung, head and neck, oesophagus, or pancreas. The doctors need to be able to measure your cancer to see if the treatment is working. Your general health and ability to perform daily activities, often described as 'performance status', should be good.

If you're joining the first part of the study, your cancer should have progressed or come back after you've had standard treatments. For the second part of the study, you shouldn't have had more than two previous treatments targeting the whole body for your advanced cancer. Any side effects from your previous cancer treatments need to have mostly cleared up or be very mild. You also need to agree to provide a small sample of your tumour tissue, if it's safe to do so.

There are also some reasons why you wouldn't be able to join. For example, if you've already had a similar type of antibody drug conjugate medicine that contains a specific kind of drug (like sacituzumab govitecan or trastuzumab deruxtecan). Also, if you have severe eating problems, sickness, or bowel issues, or specific serious lung problems, you might not be suitable for this study. The study also has other specific health conditions that would prevent you from taking part.

If you decide to take part in this study, you will have regular visits to the hospital or clinic. During these visits, doctors and nurses will monitor your health closely, perform physical exams, take blood and urine samples, and do scans to see how the treatment is affecting your cancer. The medicine, PF-08046876, will be given to you through a drip into a vein. The exact number of visits and the full length of your participation will depend on which part of the study you are in and how you respond to the treatment, but studies like this usually involve ongoing visits over several months, followed by regular check-ups.

It's important to understand that research studies require careful monitoring, so you should expect to spend time at the clinic for your appointments and treatment. Nurses will be on hand to answer questions and help with any side effects. You will be told the complete schedule of visits and procedures before you agree to join the study.