- recruiting
Fibrosis in Chronic and Delayed Myocardial Infarction
This study looks at how a problem called fibrosis affects different heart conditions, like when heart valves narrow, or heart damage from chemotherapy or a rare condition called carcinoid syndrome. Researchers are using special scans to spot this fibrosis early and understand it better.
United Kingdom - recruitingPHASE2
A Multicenter Trial Assessing the Impact of Lipoprotein(a) Lowering With Pelacarsen (TQJ230) on the Progression of Calcific Aortic Valve Stenosis
This study is looking into a new medicine called Pelacarsen (TQJ230) for a heart condition called aortic stenosis. We want to see if this medicine can slow down the stiffening and narrowing of the heart's aortic valve. Participants will get either the study medicine or a dummy pill (placebo).
United States · Austria · Belgium - active not recruiting
CMR-AI and Outcomes in AS
This study uses a special computer program called AI to look at heart scans of people with a serious heart valve problem called aortic stenosis. We want to see if these AI measurements can predict how well people will do after their valve is fixed, helping doctors decide the best time for treatment.
Austria · Belgium · Germany - not yet recruiting
Avr Thrombosis OutcoMe Study
This study looks at new blood tests to find out which people having a heart valve replacement are more likely to develop blood clots. We want to see if these tests can predict problems like strokes or issues with the new valve, so we can help prevent them.
United Kingdom - recruitingNA
The Early Valve Replacement in Severe ASYmptomatic Aortic Stenosis Study
This study looks at the best time to treat a heart condition called aortic stenosis in people who don't have symptoms. It compares early surgery or a keyhole procedure to careful monitoring, to see which approach leads to better health and is more cost-effective.
Australia · Belgium · Netherlands - active not recruitingNA
PERIGON Pivotal Trial
This study looks at how safe and effective a new heart valve, called the Model 400, is for people with issues with their natural or artificial aortic heart valve. It tracks patients for many years to see how well the new valve works.
United States · Canada · France - ongoing, recruitingTherapeutic use (Phase IV)
EMPagliflozin after Aortic Valve Replacement - the EMPAVR study - a randomized clinical trial
This study, called EMPAVR, is looking into whether a drug called empagliflozin (known as Jardiance) can help hearts recover better after an operation for a heart problem called aortic stenosis. We want to see if it reduces the size of the heart's pumping chamber over 12 months.
Denmark - ongoing, recruitingPhase III and phase IV (Integrated)
Routine versus selective protamine administration to reduce bleeding complications after transcatheter aortic valve implantation
This study looks at using a medicine called protamine to help prevent serious bleeding after a heart procedure called TAVI. Researchers want to see if giving protamine to everyone or only some patients makes a difference to safety and recovery after TAVI.
Netherlands · Belgium - recruiting
Post-Market Clinical Follow Up Study With Navitor Valve
This study is looking at how well a new heart valve called Navitor works after it's been used in patients. It's for people with a condition called aortic stenosis, where a heart valve doesn't open properly, and aims to check its safety and how long it lasts in real-world use.
Australia · France · Germany - recruiting
The Scottish Aortic Stenosis LongiTudinal Imaging and biomarkeR (SALTIRE) Programme
This study looks at a heart condition called aortic stenosis, where a heart valve narrows. We want to understand what causes it and how it gets worse. We'll use special scans and tests to track changes in people with the condition and those who've had valve replacements.
United Kingdom