- not yet recruitingPhase II
Trial to establish whether dapagliflozin and spironolactone in patients with severe aortic stenosis undergoing aortic valve replacement result in better left ventricular mass regression, myocardial health and patient-reported outcomes than standard-of-care therapy alone
This UK study tests whether two common heart medications, dapagliflozin and spironolactone, help the heart muscle heal after a valve replacement for severe aortic stenosis. Researchers want to see if taking one or both tablets for a year improves heart recovery and daily wellbeing compared to standard care alone.
United Kingdom · England - recruitingTherapeutic confirmatory (Phase III)
AntiCoagulation versus AcetylSalicylic Acid after Transcatheter Aortic Valve Implantation
This study is looking at different blood-thinning medicines after a keyhole heart valve operation for a condition called aortic stenosis. We want to find the safest and most effective medication to prevent problems like blood clots and bleeding, comparing them to aspirin.
Norway - recruitingPhase III and phase IV (Integrated)
Routine versus selective protamine administration to reduce bleeding complications after transcatheter aortic valve implantation
This study looks at using a medicine called protamine to help prevent serious bleeding after a heart procedure called TAVI. Researchers want to see if giving protamine to everyone or only some patients makes a difference to safety and recovery after TAVI.
Netherlands · Belgium - recruitingTherapeutic use (Phase IV)
EMPagliflozin after Aortic Valve Replacement - the EMPAVR study - a randomized clinical trial
This study, called EMPAVR, is looking into whether a drug called empagliflozin (known as Jardiance) can help hearts recover better after an operation for a heart problem called aortic stenosis. We want to see if it reduces the size of the heart's pumping chamber over 12 months.
Denmark - active not recruitingNA
PARTNER 3 Trial: Safety and Effectiveness of the SAPIEN 3 Transcatheter Heart Valve in Low Risk Patients With Aortic Stenosis
This study compares two ways to replace a heart valve (aortic valve) in people with a condition called aortic stenosis. It looks at a new, less invasive method (TAVR) versus traditional open-heart surgery for patients who are generally healthy.
United States · Australia · Canada - not yet recruiting
Prospective, Long-term Evaluation of the SAPIEN 3 Ultra RESILIA Valve
This study looks at how well a new heart valve, called SAPIEN 3 Ultra RESILIA, works in patients with heart valve problems. Researchers will follow patients for up to 10 years to see how the valve performs and affects their health.
Germany - recruitingPHASE4
Angiotensin Receptor Blockers in Aortic Stenosis
This study is looking at whether a common type of blood pressure medicine, called ARBs, can help slow down a heart valve problem called aortic stenosis. We want to see if ARBs can protect the heart and stop the condition from getting worse in people with a mild to moderate form of the disease.
Canada · Denmark - recruiting
Phenotyping Heterogeneity and Regionality of the Aorta
This study aims to better understand how the body's main artery, the aorta, works and changes in people with certain heart conditions. Researchers will collect health information from healthy volunteers and patients with aortic problems to learn more about these conditions.
Germany - recruitingNA
PARTNER 3 Trial - Aortic Valve-in-Valve
This study looks at a new heart valve called SAPIEN 3/SAPIEN 3 Ultra. It's for people whose artificial aortic heart valve is failing. Doctors want to check how safe and effective this new valve is for these patients.
United States · Canada - active not recruitingNA
Transcatheter Aortic Valve Replacement Versu Surgical Aortix Valve Replacement for Treating Elderly Patients With Severe Aortic Stenosis and Small Aortic Annuli: A Prospective Randomized Study The VIVA Trial
This study compares two ways to replace a heart valve: surgery or a less invasive procedure. It's for older patients with a specific heart valve problem called severe aortic stenosis, where the valve opening is smaller than usual. It aims to see which method works best and is safest for them.
Canada - active not recruitingNA
ACURATE IDE: Safety and Effectiveness Study of ACURATE Valve for Transcatheter Aortic Valve Replacement
This study looked at a new heart valve called ACURATE for people with a serious heart condition called aortic stenosis. It compared the ACURATE valve to other common valves to see if it was safe and worked well. However, the company has stopped making the ACURATE valve.
United States · Canada - recruiting
Avr Thrombosis OutcoMe Study
This study looks at new blood tests to find out which people having a heart valve replacement are more likely to develop blood clots. We want to see if these tests can predict problems like strokes or issues with the new valve, so we can help prevent them.
United Kingdom - recruiting
The Scottish Aortic Stenosis LongiTudinal Imaging and biomarkeR (SALTIRE) Programme
This study looks at a heart condition called aortic stenosis, where a heart valve narrows. We want to understand what causes it and how it gets worse. We'll use special scans and tests to track changes in people with the condition and those who've had valve replacements.
United Kingdom - recruiting
Post-Market Clinical Follow Up Study With Navitor Valve
This study is looking at how well a new heart valve called Navitor works after it's been used in patients. It's for people with a condition called aortic stenosis, where a heart valve doesn't open properly, and aims to check its safety and how long it lasts in real-world use.
Australia · France · Germany - recruiting
Fibrosis in Chronic and Delayed Myocardial Infarction
This study looks at how a problem called fibrosis affects different heart conditions, like when heart valves narrow, or heart damage from chemotherapy or a rare condition called carcinoid syndrome. Researchers are using special scans to spot this fibrosis early and understand it better.
United Kingdom - recruitingPHASE2
A Multicenter Trial Assessing the Impact of Lipoprotein(a) Lowering With Pelacarsen (TQJ230) on the Progression of Calcific Aortic Valve Stenosis
This study is looking into a new medicine called Pelacarsen (TQJ230) for a heart condition called aortic stenosis. We want to see if this medicine can slow down the stiffening and narrowing of the heart's aortic valve. Participants will get either the study medicine or a dummy pill (placebo).
United States · Austria · Belgium - recruitingNA
The Early Valve Replacement in Severe ASYmptomatic Aortic Stenosis Study
This study looks at the best time to treat a heart condition called aortic stenosis in people who don't have symptoms. It compares early surgery or a keyhole procedure to careful monitoring, to see which approach leads to better health and is more cost-effective.
Australia · Belgium · Netherlands - active not recruiting
CMR-AI and Outcomes in AS
This study uses a special computer program called AI to look at heart scans of people with a serious heart valve problem called aortic stenosis. We want to see if these AI measurements can predict how well people will do after their valve is fixed, helping doctors decide the best time for treatment.
Austria · Belgium · Germany - active not recruitingNA
PERIGON Pivotal Trial
This study looks at how safe and effective a new heart valve, called the Model 400, is for people with issues with their natural or artificial aortic heart valve. It tracks patients for many years to see how well the new valve works.
United States · Canada · France