A Multicenter Trial Assessing the Impact of Lipoprotein(a) Lowering With Pelacarsen (TQJ230) on the Progression of Calcific Aortic Valve Stenosis

To join this study, we are looking for men and women between the ages of 50 and 80. You would need to have been diagnosed with either mild or moderate calcific aortic valve stenosis, which is when the aortic valve is becoming stiff and narrowed. We also need to check your blood for a specific fat called Lipoprotein(a) – your levels would need to be above a certain amount for you to take part.

There are also some reasons why you might not be able to join. For example, if your aortic stenosis is already severe, or if you have certain other serious health issues like uncontrolled high blood pressure, severe kidney or liver problems, or a history of certain cancers or bleeding in the brain. They also can't include women who are pregnant or breastfeeding.

All your existing health conditions that might increase your risk of heart problems would need to be well managed before you start the study. There might be some other specific reasons why you couldn't take part, which the study team would explain to you.

If you decide to take part, you would receive monthly injections, either of the study medicine Pelacarsen or a placebo (a dummy medicine that looks the same but contains no active drug). You wouldn't know which one you are getting. Throughout the study, you'd have regular check-ups, which would involve blood tests, heart scans (like echocardiograms to look at your aortic valve), and general health assessments. These visits are important so the study team can monitor your health, how the medicine is affecting you, and how your aortic stenosis is progressing. The total duration of your participation in the study would be explained by the research team.