Atrial Fibrillation (AF) research hub
36 indexed studies · 27 currently recruiting
- authorisedTherapeutic confirmatory (Phase III)
A Master Protocol for a Phase 3, Randomized, Multicenter, Double-blind Study to Assess Stroke and Systemic Embolism Prevention with REGN7508 and REGN9933, Monoclonal Antibodies Against Factor XI, versus Placebo in Participants with Atrial Fibrillation for Whom Oral Anticoagulation is Unsuitable (ROXI-INCLINE)
This clinical study tests two new medicines, REGN7508 and REGN9933, for adults with atrial fibrillation (an irregular heartbeat). It aims to find out if these treatments can safely stop blood clots and strokes in people who cannot take standard blood-thinning tablets due to a high risk of bleeding.
Spain · Bulgaria · Hungary - authorisedTherapeutic confirmatory (Phase III)
A Phase 3, Randomized, Multicenter, Double-blind Study to Assess Stroke and Systemic Embolism Prevention with REGN7508, a Monoclonal Antibody Against Factor XI, Versus Apixaban in Participants with Atrial Fibrillation (ROXI-EVEREST)
This study tests a new medicine called REGN7508 for adults with atrial fibrillation, an irregular heartbeat. Researchers want to see if it prevents strokes as effectively as the standard blood thinner, apixaban, while causing less bleeding. Participants receive either the new treatment or the standard medicine alongside regular check-ups.
Portugal · Germany · Italy - recruitingNA
Cardiac Arrhythmia Telemetry; Conventional vs HeartWatch
This study compares a new device called HeartWatch with standard heart monitors (Holter monitors). It aims to see how well HeartWatch, worn on your upper arm, can detect common heart rhythm problems like atrial fibrillation and help understand your symptoms more effectively over a longer time.
Canada - recruitingNA
Personalized Atrial Fibrillation Ablation Guided by Non-Invasive Global Mapping
This study looks at a new way to treat atrial fibrillation (a fast, irregular heartbeat) using a special mapping system to guide a procedure called ablation. It aims to see if this personalized approach works better than standard treatment for stopping AF and preventing it from coming back.
Germany · Portugal · Spain - active not recruiting
Precision Detection and Prediction of Atrial Arrhythmias Using Artificial Intelligence and Consumer Wearable Devices
This study is looking into using smartwatches and other wearable devices, along with artificial intelligence (AI), to improve how we find and predict atrial fibrillation (AF) – a common heart rhythm problem. The aim is to make detection easier, less invasive, and more continuous than current methods.
United Kingdom - not yet recruitingNA
AV Nodal Ablation With Conduction System Pacing Versus Cardiac Resynchronization for Symptomatic Heart Failure Patients With Atrial Fibrillation
This study compares two ways to help hearts in people with heart failure and a fast, irregular heartbeat (atrial fibrillation). It looks at whether a new pacing method works as well as a standard one after a procedure to control the heart's rhythm, hoping to improve symptoms and quality of life.
France · Germany · Italy - recruitingPHASE2
Clinical Randomised Phase 2 Trial of AP31969 Versus Placebo for Rhythm Control of Atrial Fibrillation
This study is testing a new medicine, AP31969, for people with an irregular heartbeat called atrial fibrillation. We want to see if it helps control heart rhythm and if it's safe, compared to a dummy pill.
Bulgaria · Denmark · Germany - recruiting
Electrophysiological Registry Duesseldorf
This study at University Hospital Düsseldorf looks at heart rhythm problems like atrial fibrillation. It gathers information from patients having common heart procedures to understand how well they work and if they are safe. This helps improve future care.
Germany - not yet recruitingNA
Microvisk Continuous Blood Donation Study
This study is helping to develop new blood test strips for people taking warfarin. These strips aim to make regular checks on your blood clotting easier and more accurate. Your blood samples will help improve these new tests.
United Kingdom - recruitingPHASE4
Monotherapy With P2Y12 Inhibitors in Patients With Atrial fIbrillation Undergoing Supraflex Stent Implantation
This study compares different ways to give blood-thinning medicines to people who have an irregular heartbeat (atrial fibrillation) and have had a heart stent fitted. It looks at whether using fewer medicines a bit sooner can be safer while still protecting the heart.
Belgium · France · Germany - active not recruitingNA
StatSeal vs Figure-of-Eight Suture for Vascular Closure in AF Ablation
This study compares two ways to close blood vessels after a heart procedure for atrial fibrillation (AF). It looks at whether a special disc (StatSeal) helps patients walk sooner than a traditional stitch (figure-of-eight suture) and if it's safer and more comfortable.
United Kingdom - recruiting
Novel Technologies to Improve Echocardiographic Estimates of Left Ventricular Filling Pressure in Heart Failure Combined With Atrial Fibrillation
This study is testing new ultrasound methods to better understand heart failure in people with atrial fibrillation. It aims to improve how doctors measure pressure in the heart, leading to better diagnosis and treatment, and help predict who might be at higher risk.
United States · Belgium · France - active not recruitingNA
Abbott Medical - VERITAS Study
This study is looking at a new device called the Amulet™ 2. It's for people with irregular heartbeat (atrial fibrillation) who are at risk of stroke. The device aims to prevent strokes without needing long-term blood thinners.
United States · Belgium · Canada - not yet recruitingNA
WSO BEAT STROKE Initiative
This study looks at whether a special learning program for doctors can help them better follow guidelines for preventing future strokes, especially those caused by heart problems. It checks if bringing heart and brain specialists together improves care for people who've had a stroke.
Canada - recruitingNA
Perioperative Anticoagulant Use for Surgery Evaluation -2 (PAUSE-2) Study Patients Receiving a Direct Oral Anticoagulant (DOACs-Dabigatran, Rivaroxaban, Apixaban or Edoxaban) and Needing Elective High-Bleed-Risk Surgery or an Invasive Procedure
This study compares two ways to manage blood thinners (DOACs) before surgery for people with atrial fibrillation or a history of blood clots. It aims to find the safest method for people having surgery with a high risk of bleeding.
United States · Belgium · Canada - recruitingNA
Conquer-AF Protocol for Redo Ablation Procedures in Recurrent Paroxysmal and Persistent Atrial Fibrillation Using the Sphere-9 Catheter and Affera Ablation System (Conquer-AF)
This study looks at a new way to treat atrial fibrillation (AF), a common heart rhythm problem. It's for people who have already had one treatment for AF and it has come back. Doctors will use a special catheter to try and fix the irregular heartbeat.
United States · Australia · Belgium - recruitingNA
Comprehensive LEFt Atrial Appendage Occlusion With Rhythm Restoration
This study looks at combining two heart procedures: one to control an irregular heartbeat (AF) and another to reduce stroke risk. It's for people with AF who need both treatments and aims to see if doing them together is safe and works well.
Belgium · Czechia · Denmark - recruiting
COCONUT Study Concomitant PVI and LAAC
The COCONUT study looks at combining two heart procedures, PVI and LAAC, for people with an irregular heartbeat (AF) who are at high risk of stroke. It investigates if doing them together, using a new technique called PFA, is safe and works well.
Germany - recruitingNA
Treating Atrial Fibrillation in Heart Failure With Preserved Ejection Fraction: Ablation or Medication
This study looks at two ways to treat an irregular heartbeat (atrial fibrillation) in people with certain types of heart failure: a procedure called ablation or daily medicines. It aims to see which treatment works better for improving quality of life, reducing hospital stays, and helping people live longer.
Canada - active not recruitingNA
From the Emergency Department Directly to Ablation of Atrial Fibrillation Study
This study looks at treating a common heart rhythm problem called atrial fibrillation (AF) right when patients arrive at the emergency room. It compares standard care with a keyhole procedure called ablation to see if early treatment works better.
Germany - recruitingNA
A Global Study Comparing Pulsed Field Ablation With Electrographic Flow Mapping Versus Posterior Wall Ablation for Persistent Atrial Fibrillation
This study looks at a new way to treat a type of irregular heartbeat called persistent atrial fibrillation. It compares two methods of a treatment called pulsed field ablation to see if one is safer and works better at stopping the heart from beating irregularly.
United States · Belgium · France - recruitingNA
Artificial Intelligence Mapping and Ablation of Non-Pulmonary Vein Electrical Drivers of AF Study
This study looks at a new AI tool, vMap®, to help treat an irregular heartbeat called Atrial Fibrillation (AF). We're comparing using vMap® alongside a standard treatment (PVI) to using PVI alone, to see if it improves outcomes for people with AF.
United States · Germany - recruitingNA
Left Atrial Imaging Prior to Cardioversion: Leveraging Computed Tomography to Rule Out Thrombus in The Emergency Department (LA CLOTTED)
This study looks at using a special heart scan called CCT in the emergency department for people with an irregular heartbeat (AF). It aims to see if this scan helps them get treatment faster, prevents hospital stays, and improves their quality of life compared to standard care.
United States · Canada - not yet recruitingNA
Catheter Ablation for AF in Patients With Severe Mitral Regurgitation After Successful Transcatheter Mitral-Valve Repair
This study looks at whether a heart procedure called catheter ablation helps patients who have irregular heartbeats (AF) and have recently had a repair for a leaky heart valve. It compares ablation to usual care to see which is better at preventing serious heart problems.
Germany - active not recruitingNA
Responding to AF: Pill-in-Pocket Anticoagulation Guided by Automated Monitoring and Alerts
This study looks into a new way to treat Atrial Fibrillation (AF), a common irregular heartbeat. Instead of daily blood thinners, patients might take a "pill-in-pocket" dose only when their heart flutters, guided by a special monitor and phone alerts.
United Kingdom - recruitingNA
Substrate Remodelling and Targeted Ablation in AF
This study at St Bartholomew's Hospital explores how detailed heart maps can improve a procedure called catheter ablation for atrial fibrillation (AF). Researchers hope to make this common heart condition treatment more effective for patients, reducing the need for repeat procedures and improving quality of life.
United Kingdom - recruitingPHASE3
Study to evaLuate the effIcacy and Safety of abeLacimab in High-risk Patients With Atrial Fibrillation Who Have Been Deemed Unsuitable for Oral antiCoagulation (LILAC-TIMI 76)
This study looks at a new medicine, abelacimab, for people with an irregular heartbeat (atrial fibrillation) who can't take usual blood thinners. It compares abelacimab to a dummy medicine to see if it can prevent strokes.
United States · Argentina · Brazil - active not recruiting
FARAPULSE Workflow Assessment Registry
This study looks at how clinics use a new treatment called Pulsed Field Ablation (using the FARAPULSE system) for an irregular heartbeat called Atrial Fibrillation. It aims to find the best ways to use this treatment and improve patient care.
Austria · Belgium · France - recruiting
AIC Genotyping Study
This study looks at how certain gene changes might make some people with an irregular heartbeat (Atrial Fibrillation or AF) more likely to develop a weakened heart muscle (heart failure). We're comparing genes in different groups of people to understand this better.
United Kingdom - not yet recruiting
Understanding the Increased Risk of Atrial Fibrillation in Athletes: a Case-control Study
This study looks into why athletes might have a higher risk of an irregular heartbeat called atrial fibrillation. Researchers will compare athletes with and without this condition to understand how heart changes and genetics could play a role.
United Kingdom - active not recruiting
Unrecognised Comorbidity Detection in Hospitalised Patients
This study aims to find hidden long-term conditions like diabetes and heart problems in hospital patients. By using routine hospital information, researchers hope to build a digital tool to identify patients who might benefit from earlier diagnosis and treatment, improving their health outcomes.
United Kingdom - recruiting
Mechanisms of Myocardial Injury and Ischemia in Patients With Rapid Atrial Fibrillation
This study looks at people with a very fast and irregular heartbeat (called atrial fibrillation). We want to understand if heart damage in these patients is linked to blocked heart arteries, and if signs of not enough oxygen to the heart are linked to heart attacks seen on scans.
United Kingdom - recruiting
Mechanisms of Atrial Pathoelectrophysiology in HCM
This study looks into why an irregular heartbeat (atrial fibrillation) is common and hard to treat in people with a thickened heart muscle condition (HCM). Researchers will use heart scans and electrical tests to understand it better, hoping to find improved future treatments.
United Kingdom - recruiting
Advancing Knowledge in Ischemic Stroke Patients on Oral Anticoagulants
This study looks at people who have a stroke while taking blood thinners for an irregular heartbeat. It aims to understand why this happens and what treatments work best afterwards to prevent another stroke. Researchers will collect information from medical records and follow some patients over time.
Croatia · Denmark · Egypt - recruitingNA
Cryoballoon/Radiofrequency/Pulsed Field Ablation of Atrial Fibrillation Versus Medical Treatment for Heart
This study is looking at the best way to treat an irregular heartbeat called atrial fibrillation (AF) if you also have heart failure. Doctors want to see if a procedure called catheter ablation works better than just medicines to reduce hospital stays and improve life quality.
Canada · United Kingdom - recruiting
Patient Selection and Long-Term Outcomes of Pace & Ablate Strategy in Atrial Fibrillation
This study looks at a heart treatment called 'pace and ablate' for people with an irregular heartbeat (atrial fibrillation). It aims to find out who might get a side effect where the heart muscle weakens and how to avoid it, while also checking costs.
Poland · Switzerland · United Kingdom