Mechanisms of Myocardial Injury and Ischemia in Patients With Rapid Atrial Fibrillation
This study aims to understand why some people with a very fast and irregular heartbeat, called atrial fibrillation, might also show signs of heart damage. We're looking at whether this heart damage is connected to blocked arteries in the heart. We also want to see if signs that the heart isn't getting enough oxygen are linked to past heart attacks that can be seen on scans. To do this, we will measure a special protein in the blood called troponin, which can indicate heart damage. We will also use several heart tests, including special scans and ECGs, to get a full picture of what's happening in the heart. This will help doctors better understand and treat patients with this condition.
At a glance
What is this study about?
This study is looking into a common heart condition called atrial fibrillation, where the heart beats very quickly and irregularly. Sometimes, when this happens, blood tests can show signs of damage to the heart muscle, measured by a protein called troponin.
We want to find out two main things. Firstly, if people with a fast, irregular heartbeat and signs of heart damage are more likely to have blocked arteries in their heart, which can reduce blood flow. Secondly, if these patients, especially those whose hearts show signs of not getting enough oxygen, are more likely to have had a heart attack that can be seen on special scans.
To answer these questions, we will monitor people with a fast, irregular heartbeat who are taking part in the study. We will measure the troponin levels in their blood and then perform several heart tests, including a detailed CT scan of the heart's arteries, an ultrasound of the heart (echocardiogram), an electrical tracing of the heart (ECG), and a special magnetic scan (cardiac MRI). This will help us understand the links between these different signs of heart trouble.
Key takeaways
- The study investigates heart damage in people with a fast, irregular heartbeat.
- It aims to see if heart damage is linked to blocked heart arteries.
- Special blood tests and heart scans (CT, MRI) will be used.
- This is an observational study, so you won't receive new treatments.
- Results could help doctors better understand and treat this condition.
- You can withdraw from the study at any time.
Who may be eligible?
To join this study, you need to be at least 18 years old and experiencing symptoms because of your atrial fibrillation. Your heart rate on an electrical heart tracing (ECG) must be over 100 beats per minute due to your atrial fibrillation. You must also be able to understand the study and agree to take part.
However, you won't be able to join if you've had a heart attack or a procedure to open up blocked heart arteries before. People with severe kidney problems or a major allergy to the dye used in some scans cannot take part. Also, if you are pregnant or breastfeeding, or if the doctor thinks the study isn't right for you, you won't be able to join. You also can't join if you've already been part of this specific trial.
Could this study suit you?
Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.
- Are you 18 years old or older?
- Are you experiencing symptoms because of a fast, irregular heartbeat (atrial fibrillation)?
- Have you had a heart attack or artery-unblocking procedure in the past? (If yes, you likely can't join)
- Do you have severe kidney problems or a major allergy to scan dyes? (If yes, you likely can't join)
- Are you pregnant or breastfeeding? (If yes, you likely can't join)
What does participation involve?
This study is observational, meaning you won't be given any new medications or treatments as part of the trial itself. You will undergo several tests to help us understand your heart condition better. This will include blood tests to check troponin levels, an electrocardiogram (ECG) to measure your heart's electrical activity, an echocardiogram (a heart ultrasound), a CT coronary angiogram (a special X-ray scan of your heart's arteries), and a cardiac MRI (a more detailed scan of your heart). Most of these tests will likely be done during your hospital visit. There is no specified duration for the study, as it focuses on investigations at one point in time.
Potential risks and benefits
Locations (1)
- Royal Infirmary of EdinburghVerified postcodeEdinburgh, United Kingdom· Recruiting
Common questions
What is atrial fibrillation?
It's a condition where the heart beats very fast and irregularly, which can lead to various symptoms.
What is 'troponin'?
Troponin is a protein found in your heart muscle. When heart muscle is damaged, troponin is released into your bloodstream, and a blood test can measure it.
What is a CT coronary angiogram?
It's a special type of X-ray scan that takes detailed pictures of the arteries around your heart to check for blockages.
Will I get new medicine or treatment?
No, this study is to gather information through tests, not to give you new medicines or treatments.
How long will I be in the study?
The study involves a series of tests, usually during your hospital visit. There isn't a long-term follow-up period specified.
How to find out more
Always speak to your GP or specialist before deciding to take part in a study.
Interested in taking part?
Discussion
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