- recruiting
The MOMENTUM Study: The Multiple Outcome Evaluation of Radiation Therapy Using the MR-Linac Study
The MOMENTUM Study is tracking how a new type of advanced radiotherapy, called MR-Linac, works for people with different cancers. It aims to see if this treatment improves survival, controls cancer better, and enhances quality of life by using highly precise radiation guidance.
United States · Australia · Belgium - recruitingPHASE2
To Study the Effect of Inavolisib in Combination With Fulvestrant in Participants With Breast Cancer
This study is looking at a new combination of medicines, Inavolisib and Fulvestrant, for people with a specific type of advanced breast cancer. It aims to see how well this combination works and if it's safe after other treatments haven't worked.
United States · Argentina · Australia - not yet recruitingNA
EQUITA - A Feasibility Trial of a Faith-placed Intervention to Increase Screening Uptake in Black Adults
This study looks at how faith groups can help Black adults get important cancer and aneurysm screenings. It's a small trial in the North East, Leeds, and Scotland to see if this approach works and is well-received before a larger study.
United Kingdom - recruitingNA
Safe De-escalation of Chemotherapy for Stage 1 Breast Cancer
This study looks at how a blood test can help doctors decide on the best chemotherapy for early breast cancer. It aims to reduce strong treatments for patients who might not need them, improving their recovery and quality of life.
United Kingdom - active not recruitingPHASE2
Artificial Intelligence Supporting CAncer Patients Across Europe - the ASCAPE Project
This study uses AI to improve life quality for breast and prostate cancer patients across Europe. It aims to create personalised predictions about challenges patients might face and suggest ways doctors can help, using smart technology and data.
Greece · Spain · Sweden - recruiting
Feasibility Study to Evaluate the Use of Patient Reported Complications After Digital Consent
This study looks at how well breast cancer patients report their recovery and any problems after surgery, using an online form. It aims to see if this information can help improve how we talk about surgery risks and future patient care.
United Kingdom - active not recruitingPHASE1, PHASE2
Study of LEE011, BYL719 and Letrozole in Advanced ER+ Breast Cancer
This study looks at new drug combinations for advanced ER+ breast cancer in women aged 18-100. It tests LEE011 and BYL719 with letrozole to find safe and effective doses, hoping to improve treatment for this type of cancer.
United States · Australia · France - recruitingPHASE1
A Study Evaluating the Safety, Pharmacokinetics and Early Efficacy of AVA6000 in Solid Tumours
This study is testing a new drug, AVA6000, for people with advanced solid tumours like breast, ovarian, or salivary gland cancer. It aims to find a safe dose and see how well it works when standard treatments may no longer be effective.
United States · United Kingdom - recruiting
International Prospective REgistry on Pre-pectorAl Breast REconstruction
This study looks at how well a type of breast reconstruction works after breast cancer surgery. It's for women who have reconstruction using implants placed above the chest muscle. Doctors are collecting information on surgery, appearance, cancer results, and quality of life.
Argentina · Egypt · Greece - recruitingPHASE3
A Study to Learn About the Study Medicine Called PF-07248144 in Combination With Fulvestrant in People With HR-positive, HER2-negative Advanced or Metastatic Breast Cancer Who Progressed After a Prior Line of Treatment.
This study is testing a new medicine, PF-07248144, with an existing one, fulvestrant, for advanced breast cancer that has grown despite previous treatment. It aims to see if this combination is safe and effective.
United States · Australia · Belgium - recruitingNA
Sodium-glucose Transporter Type 2 Inhibition in Anthracycline-related Cardiotoxicity
This study looks at whether a drug called dapagliflozin can protect the heart of breast cancer patients receiving certain chemotherapy. This chemotherapy can sometimes cause heart damage, and researchers want to see if this new drug can reduce that risk.
United Kingdom - recruitingPHASE2
KORTUC Phase II - Intra-tumoural Radiation Sensitizer in Patients With Locally Advanced/Recurrent Breast Cancer
This study is testing if a very diluted version of a common chemical, hydrogen peroxide, can make radiotherapy work better for large breast cancer lumps. It involves injecting this special gel into the cancer twice a week during a standard course of radiotherapy. Early results from Japan have been promising.
India · United Kingdom - recruiting
Breast Cancer Evolution During Neoadjuvant Systemic Therapy
This study, called BELIEVE, collects tissue and blood samples from people with breast cancer before surgery. Researchers want to understand why some cancers respond well to treatment and others don't, how to better measure treatment success, and predict if cancer might return. It helps improve future breast cancer care.
United Kingdom - active not recruitingPHASE2
Study of Zelenectide Pevedotin in Participants With Advanced Breast Cancer
This study looks at a new drug, zelenectide pevedotin, for advanced breast cancer. It's for people whose cancer has a specific marker called NECTIN4. The study aims to see how well it works and if it's safe for different types of breast cancer.
United States · Australia · Belgium - recruitingPHASE1, PHASE2
A Study to Evaluate the Safety, Tolerability, Drug Levels, and Preliminary Efficacy of BMS-986507 Combinations in Adult Participants With Advanced Solid Tumors
This study is looking at new combinations of medicines for advanced lung or breast cancer. We want to see if they are safe, how much medicine gets into the body, and if they show early signs of working. It's for adults with certain types of advanced cancer.
United States · Australia · Canada - recruitingPHASE3
OP-1250 (Palazestrant) vs. Standard of Care for the Treatment of ER+/HER2- Advanced Breast Cancer
This study compares a new medicine called palazestrant with standard treatments for advanced breast cancer that has grown despite previous hormone therapy. It's for men and women whose cancer is ER-positive and HER2-negative.
United States · Argentina · Australia - recruitingPHASE1, PHASE2
A Phase I/IIa Study of AZD8205 Given Alone or Combined, in Participants With Advanced/Metastatic Solid Malignancies
This study is testing a new medicine called AZD8205, by itself or with other cancer drugs. It's for people with advanced cancers like breast, ovarian, or lung cancer, to see if it's safe and helps shrink tumours.
United States · Australia · Belgium - recruitingNA
Magseed Pro(R)/ Sentimag(R) Gen3
This study looks at a new way to mark breast cancer and affected lymph nodes before surgery. It uses a small marker called Magseed Pro and a special device called Sentimag Gen3 to help surgeons find and remove the right tissue accurately.
Germany · United Kingdom - recruitingPHASE2
A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors
This study is looking at a new treatment called HER3-DXd for people with certain advanced solid tumours that haven't responded to other treatments. It aims to see how well it works and if it's safe for different types of cancer, like melanoma, lung cancer, and breast cancer.
United States · Australia · Belgium - recruiting
Chemotherapy Induced Cognitive Impairment
This study looks into 'chemo fog' (memory/thinking problems after chemotherapy for breast cancer). Researchers want to understand why it happens, possibly due to brain inflammation, so they can find ways to help patients in the future.
United Kingdom - recruitingPHASE2
A PoC Study to Evaluate Treatments' Efficacy by Monitoring MRD Using ctDNA in HR-positive/HER2-negative EBC Population
This study looks at new treatments for HR-positive/HER2-negative breast cancer that has been surgically removed. It uses blood tests to find tiny traces of cancer that might come back. If found, patients may get new drug combinations to see if they can stop the cancer from returning.
Spain · United Kingdom - active not recruitingPHASE1
A Study to Learn About Study Medicine ALTA2618 in Adults With AKT1 E17K-Mutant Solid Tumors
This study is looking into a new medication called ALTA2618 for adults with certain advanced cancers that have a specific genetic change (AKT1 E17K mutation). The main goal is to check its safety and find the right dose.
United States · Australia · France - active not recruitingPHASE3
Trastuzumab Deruxtecan (DS-8201a) Versus Investigator's Choice for HER2-low Breast Cancer That Has Spread or Cannot be Surgically Removed [DESTINY-Breast04]
This study compares a new breast cancer drug, trastuzumab deruxtecan, with standard treatments. It's for people with HER2-low breast cancer that has spread or can't be removed by surgery and who have already had other treatments.
United States · Austria · Belgium - recruitingPHASE3
Palazestrant in Combination With Ribociclib for the First-line Treatment of ER+/HER2- Advanced Breast Cancer
This study looks at a new drug, palazestrant, combined with standard treatment (ribociclib) for advanced breast cancer that is ER-positive and HER2-negative. It compares this new combination to the standard treatment alone to see if it works better and is safe for people who haven't had other treatments for their advanced cancer.
United States · Australia · Austria - active not recruiting
Contrast-Free Magnetic Resonance Imaging for Breast Disease
This study is exploring a new MRI scan for breast problems that doesn't need a special dye. It aims to find breast changes in women, especially those with dense breasts, without using traditional contrast agents.
United Kingdom - recruitingNA
Biological Matrices Versus Synthetic Meshes
This study looks at two types of mesh used in breast reconstruction after cancer surgery: natural (biological) and man-made (synthetic). It aims to see if patients and doctors are comfortable with not choosing which mesh they get, and to check their long-term safety and how happy people are with the results.
United Kingdom - active not recruitingPHASE2
Study of Neoadjuvant Olaparib Monotherapy and Olaparib and Durvalumab Combination in HER2 Negative BRCAm Breast Cancer
This study looks at new treatments for a specific type of breast cancer with a BRCA gene change. It tests olaparib, alone or with durvalumab, before surgery. The aim is to find better ways to treat this cancer and reduce the need for strong chemotherapy.
United States · Australia · Austria - not yet recruiting
Breast Tumour Size Measurement by Field Cycling Imaging
This study looks at a new type of MRI scan called Field-Cycling Imaging (FCI) to see if it can accurately measure the size of a specific type of breast cancer (DCIS). We want to know if FCI is better than standard methods for sizing these tumours before surgery.
United Kingdom - active not recruitingPHASE3
A Study of Nonsteroidal Aromatase Inhibitors Plus Abemaciclib (LY2835219) in Postmenopausal Women With Breast Cancer
This study looks at a new combination of medicines for postmenopausal women with a certain type of breast cancer. It tests if abemaciclib with standard hormone therapy works better than hormone therapy alone.
United States · Australia · Austria - recruitingPHASE1, PHASE2
Study of Patritumab Deruxtecan With Other Anticancer Agents in Participants With HER2 Positive Breast Cancer That Has Spread and Cannot Be Surgically Removed (MK-1022-009)
This study looks into a new medicine, patritumab deruxtecan, for HER2-positive breast cancer that has spread and can't be removed by surgery. Researchers want to see if it's safe, how well people tolerate it, and if it can shrink or get rid of the cancer.
United States · Canada · Israel - recruitingPHASE1, PHASE2
A Phase I/II, Dose Finding and Optimization Study of [177Lu]Lu-NeoB in Combination With Capecitabine in Patients With GRPR+, ER+, HER2- Metastatic Breast Cancer After Progression on Previous Endocrine Therapy in Combination With a CDK4/6 Inhibitor.
This study is for people with advanced breast cancer that has grown despite previous treatments. It tests a new combination of targeted radiation therapy and chemotherapy to see if it can stop cancer growth and if it's safe. We're looking at different doses to find the best way to use these treatments.
United States · Australia · Canada - recruitingPHASE2, PHASE3
Platinum and Polyadenosine 5'Diphosphoribose Polymerisation Inhibitor for Neoadjuvant Treatment of Triple Negative Breast Cancer and/or Germline BRCA Positive Breast Cancer
This study is for people with certain types of breast cancer to see if adding a drug called olaparib to standard chemotherapy before surgery can improve treatment. It's focused on triple-negative breast cancer or breast cancer linked to a BRCA gene change.
United Kingdom - active not recruitingPHASE2, PHASE3
A Study Evaluating the Efficacy and Safety of Inavolisib + Palbociclib + Fulvestrant vs Placebo + Palbociclib + Fulvestrant in Participants With PIK3CA-Mutant, Hormone Receptor-Positive, HER2-Negative, Locally Advanced or Metastatic Breast Cancer
This study looks at a new drug, Inavolisib, combined with standard treatments (Palbociclib and Fulvestrant) for a specific type of advanced breast cancer. It compares this new combination to the standard treatments alone, checking how well it works and if it's safe.
United States · Argentina · Australia - active not recruiting
NOSTRA-Feasibility Study: A Study Looking at Ultrasound Guided Biopsies for Breast Cancer
This study looks into whether we can use special ultrasound-guided biopsies to check for breast cancer cells after treatment. The aim is to see if some patients might be able to avoid surgery if their cancer has responded well to chemotherapy and targeted drugs.
United Kingdom - active not recruiting
The EMBRACE Study The EMBRACE Study
This study looks at how breast cancer chemotherapy affects the heart. Some treatments can weaken the heart. Researchers want to find out if changes in the heart's energy happen before any damage, so they can find ways to protect it early.
United Kingdom - active not recruitingPHASE1
A Study of GDC-9545 Alone or in Combination With Palbociclib and/or Luteinizing Hormone-Releasing Hormone (LHRH) Agonist in Locally Advanced or Metastatic Estrogen Receptor-Positive Breast Cancer
This study is looking at a new drug, GDC-9545, for advanced breast cancer that has spread. It will check if the drug is safe and effective, both on its own and with other treatments. It's for women whose cancer is hormone-sensitive.
United States · Australia · South Korea - active not recruitingPHASE1, PHASE2
A Phase 1-2 Study of ST101 in Patients With Advanced Solid Tumors
This study is testing a new drug, ST101, for people with advanced cancers like breast cancer, melanoma, and glioblastoma. It aims to see if the drug is safe, how much to give, and if it could help shrink tumors. It's for adults whose cancer hasn't responded to other treatments.
United States · United Kingdom - active not recruitingPHASE3
A Study Evaluating the Efficacy and Safety of Adjuvant Atezolizumab or Placebo and Trastuzumab Emtansine for Participants With HER2-Positive Breast Cancer at High Risk of Recurrence Following Preoperative Therapy
This study looked at new treatments for HER2-positive breast cancer that had already been treated but still showed signs of cancer after surgery. Researchers wanted to see if adding certain drugs could prevent the cancer from coming back.
United States · Australia · Austria - active not recruiting
Male Breast Cancer: Understanding the Biology for Improved Patient Care
This study looks at breast cancer in men. Researchers are gathering information and samples from men with breast cancer to better understand the disease and improve how it's treated. It's a large international effort to learn more about this rare condition.
United States · Belgium · Brazil - recruitingPHASE1
A Study of MGC026 in Participants With Advanced Solid Tumors
This study is testing a new medicine called MGC026 for people with advanced cancers that have come back or spread. Doctors want to see if it's safe, what side effects it causes, and if it can help slow down or shrink tumors.
United States · Australia · United Kingdom - active not recruiting
The OPBC-07/microNAC Study
This study looks at whether it's safe to skip a full lymph node removal surgery in breast cancer patients who have only tiny traces of cancer left in their armpit lymph nodes after chemotherapy. It checks how these patients have fared over time.
United States · Argentina · Australia - recruiting
An Investigation Into Dielectric Assessment of Permittivity and Conductivity in Human Using a Novel Electrical Capacitance Tomography Scanner
This study uses a new Z-scanner to check for breast cancer and other breast conditions. It aims to see if the scanner can tell the difference between healthy, harmless, and cancerous breast tissue by measuring electrical properties. This might help improve early detection methods.
United Kingdom - active not recruitingPHASE3
A Study Evaluating the Efficacy and Safety of Inavolisib Plus Fulvestrant Compared With Alpelisib Plus Fulvestrant in Participants With HR-Positive, HER2-Negative, PIK3CA Mutated, Locally Advanced or Metastatic Breast Cancer Post CDK4/6i and Endocrine Combination Therapy
This study looks at two drug combinations, inavolisib with fulvestrant, and alpelisib with fulvestrant, for advanced breast cancer that has specific genetic changes and has already been treated with certain therapies. It aims to see which combination works better and is safer.
United States · Argentina · Australia - active not recruitingPHASE3
Study of Pembrolizumab (MK-3475) Versus Placebo in Combination With Neoadjuvant Chemotherapy & Adjuvant Endocrine Therapy in the Treatment of Early-Stage Estrogen Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative (ER+/HER2-) Breast Cancer (MK-3475-756/KEYNOTE-756)
This study looks at a new drug, pembrolizumab, for early-stage breast cancer. It's for people with a specific type of breast cancer (ER+/HER2-). Researchers want to see if adding pembrolizumab to standard chemotherapy and hormone therapy works better than standard treatment alone.
United States · Australia · Belgium - active not recruitingPHASE3
A Phase-3, Open-Label, Randomized Study of Dato-DXd Versus Investigator's Choice of Chemotherapy (ICC) in Participants With Inoperable or Metastatic HR-Positive, HER2-Negative Breast Cancer Who Have Been Treated With One or Two Prior Lines of Systemic Chemotherapy (TROPION-Breast01)
This study tests a new drug, Dato-DXd, for advanced breast cancer. It compares Dato-DXd to standard chemotherapy in women whose cancer is HR-positive and HER2-negative and has already been treated with other chemotherapy. Researchers want to see if Dato-DXd works better.
United States · Argentina · Belgium - active not recruitingPHASE3
A Study of Dato-DXd With or Without Durvalumab Versus Investigator's Choice of Therapy in Patients With Stage I-III Triple-negative Breast Cancer Without Pathological Complete Response Following Neoadjuvant Therapy (TROPION-Breast03)
This study looks at new drug combinations for stage I-III triple-negative breast cancer that hasn't fully responded to initial treatment. It compares Dato-DXd with or without Durvalumab against standard treatments to see if they're more effective and safe.
United States · Belgium · Brazil - recruitingPHASE1, PHASE2
Open-Label Umbrella Study To Evaluate Safety And Efficacy Of Elacestrant In Various Combination In Participants With Metastatic Breast Cancer
This study is testing a new drug called elacestrant with other breast cancer medicines. It's for people with a specific type of advanced breast cancer that has spread. The main goals are to see if these drug combinations are safe and if they can help shrink the cancer.
United States · Argentina · Australia - recruiting
Prospective Evaluation of AI R&D Tool for Patient Stratification - MoA Evaluation in Triple Negative Breast Cancer (PEAR-MET)
This study is testing a new tool for people with advanced triple-negative breast cancer. It uses a small sample of your tumour to see how it might react to different treatments. This helps researchers understand how to better choose treatments in the future, aiming to improve care for patients.
United Kingdom - active not recruitingPHASE3
Add-Aspirin: A Trial Assessing the Effects of Aspirin on Disease Recurrence and Survival After Primary Therapy in Common Non Metastatic Solid Tumours
This study looks at whether taking aspirin daily after cancer treatment can stop cancer coming back and help people live longer. It focuses on common cancers like breast, bowel, and prostate cancer.
Ireland · United Kingdom - recruitingPHASE2
A Phase II Study Evaluating the Efficacy and Safety of Inavolisib Plus Ribociclib Plus Fulvestrant Versus Placebo Plus Ribociclib Plus Fulvestrant in Participants With Advanced Breast Cancer
This study is looking at a new combination of medicines for advanced breast cancer that has stopped responding to hormone therapy. It aims to see if combining inavolisib with ribociclib and fulvestrant works better than the current treatment.
United States · Argentina · Brazil