- active not recruitingPHASE3
Olaparib as Adjuvant Treatment in Patients With Germline BRCA Mutated High Risk HER2 Negative Primary Breast Cancer
This study looks at a drug called Olaparib for people in the UK with a specific type of breast cancer linked to a BRCA gene change. It aims to see if Olaparib, given after standard treatments, can help prevent the cancer from coming back.
United States · Argentina · Australia - recruitingPHASE3
A Phase III Study of Dato-DXd With or Without Durvalumab Compared With Investigator's Choice of Chemotherapy in Combination With Pembrolizumab in Patients With PD-L1 Positive Locally Recurrent Inoperable or Metastatic Triple-negative Breast Cancer (TROPION-Breast05)
This study looks at new treatments for a type of breast cancer called triple-negative. It compares a new drug, Dato-DXd, sometimes with Durvalumab, against standard chemotherapy with Pembrolizumab for patients whose cancer has come back locally or spread.
United States · Argentina · Australia - recruitingPHASE1
A Study of LOXO-783 in Patients With Breast Cancer/Other Solid Tumors
This study is looking into a new medicine, LOXO-783, for breast cancer and other solid tumours with a specific gene change (PIK3CA). It aims to understand if the medicine is safe, what side effects it has, and how well it works.
United States · Australia · Belgium - recruitingPHASE3
Palazestrant in Combination With Ribociclib for the First-line Treatment of ER+/HER2- Advanced Breast Cancer
This study looks at a new drug, palazestrant, combined with standard treatment (ribociclib) for advanced breast cancer that is ER-positive and HER2-negative. It compares this new combination to the standard treatment alone to see if it works better and is safe for people who haven't had other treatments for their advanced cancer.
United States · Australia · Austria - recruitingNA
Safe De-escalation of Chemotherapy for Stage 1 Breast Cancer
This study looks at how a blood test can help doctors decide on the best chemotherapy for early breast cancer. It aims to reduce strong treatments for patients who might not need them, improving their recovery and quality of life.
United Kingdom - active not recruitingPHASE3
Gedatolisib Plus Fulvestrant With or Without Palbociclib vs Standard-of-Care for the Treatment of Patients With Advanced or Metastatic HR+/HER2- Breast Cancer (VIKTORIA-1)
This study looks at new drug combinations for advanced breast cancer that has grown despite previous treatments. It compares different medications, including gedatolisib, fulvestrant, and palbociclib, to see if they are safe and effective.
United States · Argentina · Australia - recruitingNA
Pilot Study of PACHA Program to Enhance Adherence to Adjuvant Endocrine Therapy Among Breast Cancer Survivors
This study looks at a new programme, PACHA, to help women with breast cancer stick to their hormone treatment. It checks if the programme, run from local pharmacies, is easy to use, helpful, and could be studied on a bigger scale.
Canada - recruitingNA
Breast cancEr, FITness and ExeRcise for Heart Health: The BE-FITTER Study
This study looks at how exercise or yoga helps older women who've had breast cancer and chemotherapy. It checks if these activities can improve heart and muscle health and make daily tasks easier.
Canada - recruitingNA
Partial Breast Re-irradiation Using Ultra Hypofractionation (PRESERVE)
This study looks at a new, shorter radiation treatment for women whose breast cancer has come back, or who have developed a new cancer in the same breast after earlier treatment. It aims to see if this quicker, one-week course of radiation is safe and works well.
United States · Australia · Brazil - recruitingPHASE2
A Study to Test Inavolisib Treatments in Participants With Early-Stage, PIK3CA-Mutated Breast Cancer
This study is looking at new treatments for early-stage breast cancer. It focuses on a specific type of breast cancer (ER-positive, HER2-negative) that has a particular gene change (PIK3CA mutation). Researchers want to see how safe and effective the new medicine, Inavolisib, is when combined with other known treatments.
United States · Argentina · Brazil - active not recruitingNA
Randomized Phase III Trial With Mepitel Film for the Prophylaxis of Radiation Dermatitis in Breast Cancer Patients
This study looks into using Mepitel Film to help prevent skin reactions during radiotherapy for breast cancer. It compares the film to standard skin care to see if it reduces problems like redness and soreness, especially for certain patients.
Canada - recruiting
EXActDNA-003 / NSABP B-64: Study of Molecular Residual Disease Detection in Breast Cancer (MRD)
This study looks at a new way to find small amounts of breast cancer DNA in the blood after treatment. It aims to see if this test can help predict how well high-risk breast cancer patients do over time after chemotherapy.
United States · Canada - recruitingPHASE2
Neoadjuvant, SBRT With Intratumoural Pembrolizumab Followed by Neoadjuvant Chemotherapy in Breast Cancer
This study is looking at a new way to treat certain breast cancers before surgery. It combines a special type of radiation with a medicine called pembrolizumab, followed by standard chemotherapy, to see if it can make treatments more effective.
Canada - not yet recruitingNA
SABR PRIMER - Evaluating Stereotactic Ablative Radiotherapy for Primary and Regional Breast Tumors
This study looks at a special type of radiation, called SABR, for people with breast cancer that has spread. Doctors want to see if SABR can help control the cancer in the breast and surrounding areas, and if it's safe to use.
Canada - active not recruitingNA
Efficacy Study With StrataXRT for the Prophylaxis of Radiation Dermatitis in Adjuvant Breast Radiation Treatment in Large Breasted Women Using a Prone Technique
This study looks at how a special gel called StrataXRT can help prevent skin problems (like redness and soreness) for women with larger breasts having breast cancer radiotherapy. It aims to see if the gel can reduce these side effects even when women are treated lying on their front.
Canada - recruitingPHASE3
Topical Betamethasone Versus Moisturizer in Preventing Radiation Dermatitis in Large-Breasted Patients Treated in the Prone Position
This study looks at whether a cream called betamethasone can reduce skin irritation (dermatitis) caused by radiation treatment for breast cancer. It focuses on women with larger breasts who are treated lying face down (prone position).
Canada - active not recruitingPHASE1
A Study to Learn About Study Medicine ALTA2618 in Adults With AKT1 E17K-Mutant Solid Tumors
This study is looking into a new medication called ALTA2618 for adults with certain advanced cancers that have a specific genetic change (AKT1 E17K mutation). The main goal is to check its safety and find the right dose.
United States · Australia · France - recruitingPHASE1, PHASE2
A Phase I/IIa Study of AZD8205 Given Alone or Combined, in Participants With Advanced/Metastatic Solid Malignancies
This study is testing a new medicine called AZD8205, by itself or with other cancer drugs. It's for people with advanced cancers like breast, ovarian, or lung cancer, to see if it's safe and helps shrink tumours.
United States · Australia · Belgium - recruitingPHASE3
Phase 3 Study of Gedatolisib as First-Line Treatment for Patients With HR-Positive, HER2-Negative Advanced Breast Cancer (VIKTORIA-2)
This study looks at new drug combinations for advanced breast cancer. It compares a new treatment (gedatolisib with other drugs) to standard treatments. The aim is to find better ways to treat hormone-positive, HER2-negative breast cancer that has spread.
United States · Argentina · Australia - recruitingNA
Intelligent Vacuum Assisted Biopsy Immediately Before Surgery As an Intra- or Pre-Operative Surrogate for Patient Response to Neoadjuvant Chemotherapy for Breast Cancer
This study looks at a special biopsy method for breast cancer patients who have had chemotherapy before surgery. It aims to see if this biopsy can accurately tell if cancer is gone, potentially helping doctors make better treatment plans after chemo.
Austria · Germany · Switzerland - recruitingNA
Evaluation of the Interest of a Postural and Functional Analysis for the Follow-up of the Adapted Motor Activity of Patients Treated for Breast Cancer
This study looks at how a special exercise programme helps women in the UK after breast cancer surgery. It checks if the exercises are useful by seeing how they affect posture and movement over 15 months.
France - recruitingPHASE4
Comprehensive Analysis of Spatial, Temporal and Molecular Patterns of Ribociclib Efficacy and Resistance in Advanced Breast Cancer Patients
This study looks at how well a breast cancer drug called ribociclib works for women with a specific type of advanced breast cancer and why it might or might not work. It also checks for side effects and how patients feel.
Germany - recruitingNA
Efficacy and Safety of Vaginal Radiofrequency for Vulvovaginal Atrophy in Breast Cancer Patients
This study looks into whether a treatment called vaginal radiofrequency can help women with breast cancer who experience vaginal dryness. It compares this new treatment to a commonly used moisturiser to see if it offers extra relief.
France - not yet recruitingPHASE1, PHASE2
FMT in Triple Negative Breast Cancer Guided by ctDNA
This study looks at whether changing gut bacteria (FMT) can help standard treatments work better for an aggressive type of breast cancer (TNBC). It aims to check if FMT is safe and possible to use alongside usual chemotherapy and immunotherapy.
Canada - not yet recruitingNA
Validation of Capillary Microsampling for Therapeutic Drug Monitoring of CDK4/6 Inhibitors in Breast Cancer Patients (TDHOME)
This study looks at a new way to test medicine levels in breast cancer patients. Instead of a needle in your arm, we're testing finger-prick samples, which are much easier. This could help make sure you're getting the right dose and feeling your best.
France - active not recruitingPHASE3
A Phase-3, Open-Label, Randomized Study of Dato-DXd Versus Investigator's Choice of Chemotherapy (ICC) in Participants With Inoperable or Metastatic HR-Positive, HER2-Negative Breast Cancer Who Have Been Treated With One or Two Prior Lines of Systemic Chemotherapy (TROPION-Breast01)
This study tests a new drug, Dato-DXd, for advanced breast cancer. It compares Dato-DXd to standard chemotherapy in women whose cancer is HR-positive and HER2-negative and has already been treated with other chemotherapy. Researchers want to see if Dato-DXd works better.
United States · Argentina · Belgium - recruiting
International Prospective REgistry on Pre-pectorAl Breast REconstruction
This study looks at how well a type of breast reconstruction works after breast cancer surgery. It's for women who have reconstruction using implants placed above the chest muscle. Doctors are collecting information on surgery, appearance, cancer results, and quality of life.
Argentina · Egypt · Greece - active not recruitingNA
Omission of SLNB in Triple-negative and HER2-positive Breast Cancer Patients With rCR and pCR in the Breast After NAST
This study looks at whether some breast cancer patients can skip a common armpit lymph node surgery after successful chemotherapy. It focuses on specific cancer types like triple-negative or HER2-positive, where chemotherapy works very well.
Austria · Germany · Italy - recruitingPHASE3
A Study Evaluating the Efficacy and Safety of Inavolisib Plus CDK4/6 Inhibitor and Letrozole vs Placebo + CDK4/6i and Letrozole in Participants With Endocrine-Sensitive PIK3CA-Mutated, Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer
This study is looking at a new combination of medicines for a certain type of advanced breast cancer. It compares a new drug, inavolisib, with existing treatments to see if it's more effective and safe for people whose cancer has a specific genetic change (PIK3CA mutation).
United States · Argentina · Australia - recruitingNA
Prediction in Silico of Pathological Response in a Prospective Cohort Study of Early Breast Cancer Patients
This study aims to better predict how well breast cancer treatments will work for patients with early-stage breast cancer. By collecting detailed information from patients, researchers hope to develop a tool to help doctors choose the best treatment for each person.
France - active not recruitingPHASE2
Docosahexaenoic Acid (DHA) for Women With Breast Cancer in the Neoadjuvant Setting
This study looks at whether a special omega-3 fatty acid, DHA, can help women with breast cancer when given alongside their usual chemotherapy. We want to see if DHA makes chemotherapy work better and reduces side effects.
Canada - recruitingNA
Mainstreaming Genetics: Evaluation of a Digital Application to Scale and Spread Oncologist-initiated Genetic Testing
This study looks at a new digital tool called GA-Mainstream. It helps people with certain cancers like breast, ovarian, and colon cancer understand genetic testing better. The goal is to make sure patients feel informed and supported while getting tested for genes that can affect their cancer treatment.
Canada - active not recruitingPHASE3
PALbociclib CoLlaborative Adjuvant Study
This study is looking at whether adding a drug called palbociclib to standard hormone therapy can improve outcomes for people with some types of early breast cancer. It's a large, international study involving many patients.
United States · Australia · Austria - recruitingNA
MRI Screening for Brain Metastases Among Patients With Triple Negative or HER2+ Stage II or III Breast Cancer
This study looks at whether advanced breast cancer that's HER2+ or 'triple negative' has spread to the brain, even if there are no symptoms. It uses special MRI scans and blood tests to find out and understand how patients feel about these tests.
Canada - recruiting
PROVIDENCE - Prospective Non-interventional Study (NIS) to Examine Patient-reported Outcomes and Real-world Clinical Data in Patients With HER2-positive, HER2-low or HER2-ultralow Unresectable or Metastatic Breast Cancer Treated With Trastuzumab Deruxtecan
This study looks at how a new breast cancer treatment, trastuzumab deruxtecan (T-DXd), works in real life for people with advanced HER2-positive, HER2-low, or HER2-ultralow breast cancer. It will also gather information on how patients feel and their experiences with the treatment.
Germany - recruitingPHASE3
OP-1250 (Palazestrant) vs. Standard of Care for the Treatment of ER+/HER2- Advanced Breast Cancer
This study compares a new medicine called palazestrant with standard treatments for advanced breast cancer that has grown despite previous hormone therapy. It's for men and women whose cancer is ER-positive and HER2-negative.
United States · Argentina · Australia - recruitingPHASE2
A PoC Study to Evaluate Treatments' Efficacy by Monitoring MRD Using ctDNA in HR-positive/HER2-negative EBC Population
This study looks at new treatments for HR-positive/HER2-negative breast cancer that has been surgically removed. It uses blood tests to find tiny traces of cancer that might come back. If found, patients may get new drug combinations to see if they can stop the cancer from returning.
Spain · United Kingdom - recruiting
TAD in Primary Breast Cancer With Initially ≥ 3 Suspicious Lymph Nodes
This study looks at a new, less invasive surgery called TAD for breast cancer that has spread to many lymph nodes. It compares TAD to a more involved surgery (ALND) to see how effective TAD is at finding all affected nodes after chemotherapy, aiming to reduce side effects.
Germany - recruitingPHASE2
A Phase II Study Evaluating the Efficacy and Safety of Inavolisib Plus Ribociclib Plus Fulvestrant Versus Placebo Plus Ribociclib Plus Fulvestrant in Participants With Advanced Breast Cancer
This study is looking at a new combination of medicines for advanced breast cancer that has stopped responding to hormone therapy. It aims to see if combining inavolisib with ribociclib and fulvestrant works better than the current treatment.
United States · Argentina · Brazil - not yet recruitingNA
Exercise Intervention in Women Diagnosed With Triple-negative Breast Cancer Receiving Oncologic Treatment
This study looks at how high-intensity exercise might help women with a specific type of breast cancer (triple-negative breast cancer) when they're having cancer treatment. Researchers want to see if this exercise can improve how well treatments work and help the body fight the cancer better.
Germany - not yet recruitingNA
Assessment of Adherence to Remotely Monitored Physical Activity Tracked on a Smartwatch, and Its Impact on Reducing Fatigue 3 Months After Adjuvant Chemotherapy for Cancer
This study looks at how well people with certain cancers stick to a special exercise program after chemotherapy. It uses smartwatches to track activity and checks if exercise helps reduce tiredness three months later.
France - active not recruiting
Impact of the Intraoperative Use of Amines in Breast Cancer Surgery on Tumor Recurrence
This study looks at whether certain medicines given during breast cancer surgery (mastectomy) might affect if the cancer comes back. We're checking old patient records to see if these common medicines, used to keep patients stable during surgery, have any link to cancer returning.
France - recruitingPHASE3
Opioid Free Versus Opioid Based Anaesthesia for Free Flap Reconstruction Surgery of the Breast: A Phase III Multicentric Randomized Controlled Study.
This study looks at two ways to give pain relief during and after breast reconstruction surgery for breast cancer. One way uses strong pain medicine (opioids) and the other tries to use less, comparing how much pain relief is needed afterwards.
France - not yet recruitingNA
Confirmation of the Link Between Endocrine Disruptors Exposure and Breast Cancer and Identification of Biological Response Biomarkers
This study looks into the link between chemicals, called endocrine disruptors, and breast cancer. Researchers are collecting information and samples from women having breast surgery to understand how these chemicals might affect breast health and cancer development.
France - recruitingPHASE3
Phase 3 Study to Evaluate the Efficacy and Safety of HER2/Neu Peptide GLSI-100 (GP2 + GM-CSF) in HER2/Neu Positive Subjects
This study is testing a new immunotherapy, GLSI-100, for people with a specific type of HER2-positive breast cancer to see if it can stop the cancer from coming back. It involves injections given over time.
United States · Belgium · France - recruitingPHASE1
[177Lu]Lu-NeoB in Combination With Ribociclib and Fulvestrant in Participants With ER+, HER2- and GRPR+ Advanced Breast Cancer
This study looks at a new combination treatment for advanced breast cancer. It combines a special radiation drug ([177Lu]Lu-NeoB) with two existing medicines (ribociclib and fulvestrant) to see if it's safe and effective, especially for patients whose cancer has come back or worsened after previous hormone treatments.
United States · China · France - active not recruitingPHASE3
Trial of Perioperative Endocrine Therapy - Individualising Care
This study looks at a new way to treat breast cancer in postmenopausal women. It compares standard treatment with adding extra hormone therapy (aromatase inhibitors) for a short time before surgery. The aim is to see if this improves recovery and helps doctors personalise care.
United Kingdom - active not recruitingPHASE3
A Phase III Randomised Study to Evaluate Dato-DXd and Durvalumab for Neoadjuvant/Adjuvant Treatment of Triple-Negative or Hormone Receptor-low/HER2-negative Breast Cancer
This study is looking at new ways to treat a type of breast cancer that doesn't have certain hormone receptors or HER2 protein, called triple-negative or hormone receptor-low/HER2-negative breast cancer. It tests two different treatment plans using new and existing medicines before and after surgery.
United States · Australia · Austria - not yet recruiting
CLinical Evaluation Of a comPuter Algorithm To Report BreAst cAncers (CLEOPATRAA)
This study is testing a new computer program called QPORB. It helps doctors by looking at breast cancer biopsy images to see how well it can identify and classify cancer. The aim is to see if this technology can improve how breast cancer is diagnosed and treated in the UK.
United Kingdom - recruiting
To Assess the Correlation of High-resolution Specimen PET-CT Imaging, Using the XEOS AURA 10 PET-CT, With the Histopathology Results and Long-term Outcome of Patients Undergoing Resective Cancer Surgery.
This study looks at how well a special scan, called PET-CT, works on removed cancer tissue. It compares these scans with lab results and patient health over time to see if this technology can improve cancer care and treatment decisions.
Belgium · United Kingdom