- recruitingNA
Evaluation of the Interest of a Postural and Functional Analysis for the Follow-up of the Adapted Motor Activity of Patients Treated for Breast Cancer
This study looks at how a special exercise programme helps women in the UK after breast cancer surgery. It checks if the exercises are useful by seeing how they affect posture and movement over 15 months.
France - recruitingPHASE4
Comprehensive Analysis of Spatial, Temporal and Molecular Patterns of Ribociclib Efficacy and Resistance in Advanced Breast Cancer Patients
This study looks at how well a breast cancer drug called ribociclib works for women with a specific type of advanced breast cancer and why it might or might not work. It also checks for side effects and how patients feel.
Germany - recruitingNA
Efficacy and Safety of Vaginal Radiofrequency for Vulvovaginal Atrophy in Breast Cancer Patients
This study looks into whether a treatment called vaginal radiofrequency can help women with breast cancer who experience vaginal dryness. It compares this new treatment to a commonly used moisturiser to see if it offers extra relief.
France - not yet recruitingPHASE1, PHASE2
FMT in Triple Negative Breast Cancer Guided by ctDNA
This study looks at whether changing gut bacteria (FMT) can help standard treatments work better for an aggressive type of breast cancer (TNBC). It aims to check if FMT is safe and possible to use alongside usual chemotherapy and immunotherapy.
Canada - not yet recruitingNA
Validation of Capillary Microsampling for Therapeutic Drug Monitoring of CDK4/6 Inhibitors in Breast Cancer Patients (TDHOME)
This study looks at a new way to test medicine levels in breast cancer patients. Instead of a needle in your arm, we're testing finger-prick samples, which are much easier. This could help make sure you're getting the right dose and feeling your best.
France - active not recruitingPHASE3
A Phase-3, Open-Label, Randomized Study of Dato-DXd Versus Investigator's Choice of Chemotherapy (ICC) in Participants With Inoperable or Metastatic HR-Positive, HER2-Negative Breast Cancer Who Have Been Treated With One or Two Prior Lines of Systemic Chemotherapy (TROPION-Breast01)
This study tests a new drug, Dato-DXd, for advanced breast cancer. It compares Dato-DXd to standard chemotherapy in women whose cancer is HR-positive and HER2-negative and has already been treated with other chemotherapy. Researchers want to see if Dato-DXd works better.
United States · Argentina · Belgium - recruiting
International Prospective REgistry on Pre-pectorAl Breast REconstruction
This study looks at how well a type of breast reconstruction works after breast cancer surgery. It's for women who have reconstruction using implants placed above the chest muscle. Doctors are collecting information on surgery, appearance, cancer results, and quality of life.
Argentina · Egypt · Greece - active not recruitingNA
Omission of SLNB in Triple-negative and HER2-positive Breast Cancer Patients With rCR and pCR in the Breast After NAST
This study looks at whether some breast cancer patients can skip a common armpit lymph node surgery after successful chemotherapy. It focuses on specific cancer types like triple-negative or HER2-positive, where chemotherapy works very well.
Austria · Germany · Italy - recruitingPHASE3
A Study Evaluating the Efficacy and Safety of Inavolisib Plus CDK4/6 Inhibitor and Letrozole vs Placebo + CDK4/6i and Letrozole in Participants With Endocrine-Sensitive PIK3CA-Mutated, Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer
This study is looking at a new combination of medicines for a certain type of advanced breast cancer. It compares a new drug, inavolisib, with existing treatments to see if it's more effective and safe for people whose cancer has a specific genetic change (PIK3CA mutation).
United States · Argentina · Australia - recruitingNA
Prediction in Silico of Pathological Response in a Prospective Cohort Study of Early Breast Cancer Patients
This study aims to better predict how well breast cancer treatments will work for patients with early-stage breast cancer. By collecting detailed information from patients, researchers hope to develop a tool to help doctors choose the best treatment for each person.
France - active not recruitingPHASE2
Docosahexaenoic Acid (DHA) for Women With Breast Cancer in the Neoadjuvant Setting
This study looks at whether a special omega-3 fatty acid, DHA, can help women with breast cancer when given alongside their usual chemotherapy. We want to see if DHA makes chemotherapy work better and reduces side effects.
Canada - recruitingNA
Mainstreaming Genetics: Evaluation of a Digital Application to Scale and Spread Oncologist-initiated Genetic Testing
This study looks at a new digital tool called GA-Mainstream. It helps people with certain cancers like breast, ovarian, and colon cancer understand genetic testing better. The goal is to make sure patients feel informed and supported while getting tested for genes that can affect their cancer treatment.
Canada - active not recruitingPHASE3
PALbociclib CoLlaborative Adjuvant Study
This study is looking at whether adding a drug called palbociclib to standard hormone therapy can improve outcomes for people with some types of early breast cancer. It's a large, international study involving many patients.
United States · Australia · Austria - recruitingNA
MRI Screening for Brain Metastases Among Patients With Triple Negative or HER2+ Stage II or III Breast Cancer
This study looks at whether advanced breast cancer that's HER2+ or 'triple negative' has spread to the brain, even if there are no symptoms. It uses special MRI scans and blood tests to find out and understand how patients feel about these tests.
Canada - recruiting
PROVIDENCE - Prospective Non-interventional Study (NIS) to Examine Patient-reported Outcomes and Real-world Clinical Data in Patients With HER2-positive, HER2-low or HER2-ultralow Unresectable or Metastatic Breast Cancer Treated With Trastuzumab Deruxtecan
This study looks at how a new breast cancer treatment, trastuzumab deruxtecan (T-DXd), works in real life for people with advanced HER2-positive, HER2-low, or HER2-ultralow breast cancer. It will also gather information on how patients feel and their experiences with the treatment.
Germany - recruitingPHASE3
OP-1250 (Palazestrant) vs. Standard of Care for the Treatment of ER+/HER2- Advanced Breast Cancer
This study compares a new medicine called palazestrant with standard treatments for advanced breast cancer that has grown despite previous hormone therapy. It's for men and women whose cancer is ER-positive and HER2-negative.
United States · Argentina · Australia - recruitingPHASE2
A PoC Study to Evaluate Treatments' Efficacy by Monitoring MRD Using ctDNA in HR-positive/HER2-negative EBC Population
This study looks at new treatments for HR-positive/HER2-negative breast cancer that has been surgically removed. It uses blood tests to find tiny traces of cancer that might come back. If found, patients may get new drug combinations to see if they can stop the cancer from returning.
Spain · United Kingdom - recruiting
TAD in Primary Breast Cancer With Initially ≥ 3 Suspicious Lymph Nodes
This study looks at a new, less invasive surgery called TAD for breast cancer that has spread to many lymph nodes. It compares TAD to a more involved surgery (ALND) to see how effective TAD is at finding all affected nodes after chemotherapy, aiming to reduce side effects.
Germany - recruitingPHASE2
A Phase II Study Evaluating the Efficacy and Safety of Inavolisib Plus Ribociclib Plus Fulvestrant Versus Placebo Plus Ribociclib Plus Fulvestrant in Participants With Advanced Breast Cancer
This study is looking at a new combination of medicines for advanced breast cancer that has stopped responding to hormone therapy. It aims to see if combining inavolisib with ribociclib and fulvestrant works better than the current treatment.
United States · Argentina · Brazil - not yet recruitingNA
Exercise Intervention in Women Diagnosed With Triple-negative Breast Cancer Receiving Oncologic Treatment
This study looks at how high-intensity exercise might help women with a specific type of breast cancer (triple-negative breast cancer) when they're having cancer treatment. Researchers want to see if this exercise can improve how well treatments work and help the body fight the cancer better.
Germany - not yet recruitingNA
Assessment of Adherence to Remotely Monitored Physical Activity Tracked on a Smartwatch, and Its Impact on Reducing Fatigue 3 Months After Adjuvant Chemotherapy for Cancer
This study looks at how well people with certain cancers stick to a special exercise program after chemotherapy. It uses smartwatches to track activity and checks if exercise helps reduce tiredness three months later.
France - active not recruiting
Impact of the Intraoperative Use of Amines in Breast Cancer Surgery on Tumor Recurrence
This study looks at whether certain medicines given during breast cancer surgery (mastectomy) might affect if the cancer comes back. We're checking old patient records to see if these common medicines, used to keep patients stable during surgery, have any link to cancer returning.
France - recruitingPHASE3
Opioid Free Versus Opioid Based Anaesthesia for Free Flap Reconstruction Surgery of the Breast: A Phase III Multicentric Randomized Controlled Study.
This study looks at two ways to give pain relief during and after breast reconstruction surgery for breast cancer. One way uses strong pain medicine (opioids) and the other tries to use less, comparing how much pain relief is needed afterwards.
France - not yet recruitingNA
Confirmation of the Link Between Endocrine Disruptors Exposure and Breast Cancer and Identification of Biological Response Biomarkers
This study looks into the link between chemicals, called endocrine disruptors, and breast cancer. Researchers are collecting information and samples from women having breast surgery to understand how these chemicals might affect breast health and cancer development.
France - recruitingPHASE3
Phase 3 Study to Evaluate the Efficacy and Safety of HER2/Neu Peptide GLSI-100 (GP2 + GM-CSF) in HER2/Neu Positive Subjects
This study is testing a new immunotherapy, GLSI-100, for people with a specific type of HER2-positive breast cancer to see if it can stop the cancer from coming back. It involves injections given over time.
United States · Belgium · France - recruitingPHASE1
[177Lu]Lu-NeoB in Combination With Ribociclib and Fulvestrant in Participants With ER+, HER2- and GRPR+ Advanced Breast Cancer
This study looks at a new combination treatment for advanced breast cancer. It combines a special radiation drug ([177Lu]Lu-NeoB) with two existing medicines (ribociclib and fulvestrant) to see if it's safe and effective, especially for patients whose cancer has come back or worsened after previous hormone treatments.
United States · China · France - active not recruitingPHASE3
Trial of Perioperative Endocrine Therapy - Individualising Care
This study looks at a new way to treat breast cancer in postmenopausal women. It compares standard treatment with adding extra hormone therapy (aromatase inhibitors) for a short time before surgery. The aim is to see if this improves recovery and helps doctors personalise care.
United Kingdom - recruitingPHASE3
Palazestrant in Combination With Ribociclib for the First-line Treatment of ER+/HER2- Advanced Breast Cancer
This study looks at a new drug, palazestrant, combined with standard treatment (ribociclib) for advanced breast cancer that is ER-positive and HER2-negative. It compares this new combination to the standard treatment alone to see if it works better and is safe for people who haven't had other treatments for their advanced cancer.
United States · Australia · Austria - active not recruitingPHASE3
A Phase III Randomised Study to Evaluate Dato-DXd and Durvalumab for Neoadjuvant/Adjuvant Treatment of Triple-Negative or Hormone Receptor-low/HER2-negative Breast Cancer
This study is looking at new ways to treat a type of breast cancer that doesn't have certain hormone receptors or HER2 protein, called triple-negative or hormone receptor-low/HER2-negative breast cancer. It tests two different treatment plans using new and existing medicines before and after surgery.
United States · Australia · Austria - not yet recruiting
CLinical Evaluation Of a comPuter Algorithm To Report BreAst cAncers (CLEOPATRAA)
This study is testing a new computer program called QPORB. It helps doctors by looking at breast cancer biopsy images to see how well it can identify and classify cancer. The aim is to see if this technology can improve how breast cancer is diagnosed and treated in the UK.
United Kingdom - recruiting
To Assess the Correlation of High-resolution Specimen PET-CT Imaging, Using the XEOS AURA 10 PET-CT, With the Histopathology Results and Long-term Outcome of Patients Undergoing Resective Cancer Surgery.
This study looks at how well a special scan, called PET-CT, works on removed cancer tissue. It compares these scans with lab results and patient health over time to see if this technology can improve cancer care and treatment decisions.
Belgium · United Kingdom - active not recruitingPHASE3
Olaparib as Adjuvant Treatment in Patients With Germline BRCA Mutated High Risk HER2 Negative Primary Breast Cancer
This study looks at a drug called Olaparib for people in the UK with a specific type of breast cancer linked to a BRCA gene change. It aims to see if Olaparib, given after standard treatments, can help prevent the cancer from coming back.
United States · Argentina · Australia - recruiting
Real-world Evaluation of Patient Outcomes and Experiences With Ribociclib Early Adopters.
This study looks at how well new breast cancer medicines, ribociclib and abemaciclib, work for people with early-stage breast cancer, and what their experiences are like. It helps us understand how these treatments are used in real life.
United Kingdom - active not recruitingPHASE3
DS-8201a Versus T-DM1 for Human Epidermal Growth Factor Receptor 2 (HER2)-Positive, Unresectable and/or Metastatic Breast Cancer Previously Treated With Trastuzumab and Taxane [DESTINY-Breast03]
This study compares two treatments, trastuzumab deruxtecan and trastuzumab emtansine (T-DM1), for advanced HER2-positive breast cancer. It looks at how well they work and if they are safe for patients who have already had certain other treatments.
United States · Australia · Belgium - recruiting
TRIple Negative Breast Cancer Markers In Liquid Biopsies Using Artificial Intelligence
This study looks at a new blood test, called a "liquid biopsy," for an aggressive type of breast cancer. It uses AI to find out if cancer has spread or how much is left after treatment, helping doctors decide the best care.
Canada - recruitingNA
Magseed Pro(R)/ Sentimag(R) Gen3
This study looks at a new way to mark breast cancer and affected lymph nodes before surgery. It uses a small marker called Magseed Pro and a special device called Sentimag Gen3 to help surgeons find and remove the right tissue accurately.
Germany · United Kingdom - not yet recruiting
Three-Dimensional Ultrasound and Spectroscopy as Early Indicators of Breast Cancer Response to Neoadjuvant Treatment
This study uses special ultrasound scans and a technique called spectroscopy to see if we can find signs early on that breast cancer treatment is working. We're looking at how tumours respond to chemotherapy or a mix of chemotherapy and radiotherapy.
Canada - active not recruitingPHASE1
A Study of GDC-9545 Alone or in Combination With Palbociclib and/or Luteinizing Hormone-Releasing Hormone (LHRH) Agonist in Locally Advanced or Metastatic Estrogen Receptor-Positive Breast Cancer
This study is looking at a new drug, GDC-9545, for advanced breast cancer that has spread. It will check if the drug is safe and effective, both on its own and with other treatments. It's for women whose cancer is hormone-sensitive.
United States · Australia · South Korea - not yet recruitingPHASE3
NeoAdjuvant Therapy Comparing Sacituzumab Govitecan+Pembrolizumab vs. SoC Chemotherapy in Clinical Stage II-III, Triple-negative Early Breast Cancer
This study looks at new ways to treat a type of breast cancer called triple-negative early breast cancer. It compares a new drug combination with standard treatment to see if it works better at shrinking tumours before surgery and stopping cancer from coming back.
Germany - recruitingPHASE1
A Study Evaluating the Safety, Pharmacokinetics and Early Efficacy of AVA6000 in Solid Tumours
This study is testing a new drug, AVA6000, for people with advanced solid tumours like breast, ovarian, or salivary gland cancer. It aims to find a safe dose and see how well it works when standard treatments may no longer be effective.
United States · United Kingdom - recruiting
Feasibility of Serial Multisite Image-guided Biopsy to Study Breast Cancer Evolution
This study aims to understand how breast cancer changes over time, especially when it spreads. Researchers will take several small tissue samples and blood tests from different areas to see how the cancer evolves. This could help develop better treatments in the future.
United Kingdom - recruitingPHASE3
Regional Radiotherapy in Biomarker Low-Risk Node Positive and T3N0 Breast Cancer
This study looks at whether some women with early-stage breast cancer can skip a type of radiation treatment called regional radiotherapy. Researchers want to see if not having this radiation is just as good at stopping the cancer from coming back, helping women avoid unnecessary side effects.
United States · Canada - recruitingEARLY_PHASE1
B-GLUCANCER2 : A Pilot Study Evaluating a New Method for Cancer Detection by Measuring the Activity of Different Glycosidase Enzymes in the Plasma of Patients With a Localized Cancer.
This study aims to find a new way to detect cancer early using a simple blood test. Researchers are looking for tiny clues called 'glycosidases' in blood plasma that might show if someone has breast, lung, or pancreatic cancer, and how well treatments are working.
France - recruitingPHASE2
Liquid-biopsy Informed Platform Trial to Evaluate CDK4/6-inhibitor Resistant ER+/HER2- Metastatic Breast Cancer
This study looks at new ways to treat advanced breast cancer that has stopped responding to standard treatments. By checking your blood or tumour for specific signs, doctors hope to find the best treatment for you, exploring several new drugs and combinations.
Canada - recruitingPHASE2
Investigating the Effects of Atezolizumab in People Whose Tumour DNA or RNA Indicates Possible Sensitivity
This study looks at a medicine called atezolizumab for different cancers. We want to see if a special test of your cancer cells can predict if the medicine will work well for you. This helps us learn more about tailoring treatments.
Canada - active not recruitingNA
Breast-Conserving Surgery and Whole-Breast Radiation Therapy With or Without Additional Radiation Therapy to the Tumor in Treating Women With Ductal Carcinoma in Situ (BONBIS)
This study looks at treating a very early form of breast cancer called ductal carcinoma in situ (DCIS). After surgery, some women receive standard radiation, while others get standard radiation plus a small extra dose to the area where the tumour was. Scientists want to see which approach works best.
France - active not recruiting
NOSTRA-Feasibility Study: A Study Looking at Ultrasound Guided Biopsies for Breast Cancer
This study looks into whether we can use special ultrasound-guided biopsies to check for breast cancer cells after treatment. The aim is to see if some patients might be able to avoid surgery if their cancer has responded well to chemotherapy and targeted drugs.
United Kingdom - active not recruitingPHASE1, PHASE2
A Study to Learn About Vepdegestrant When Given With PF-07220060 to People With Advanced or Metastatic Breast Cancer.
This study is testing two new medicines, vepdegestrant and PF-07220060, for advanced breast cancer that has spread and isn't responding to previous treatments. Researchers want to see if the combination is safe and effective.
United States · Belgium · Canada - recruiting
LIVInG With chrONic Cancer TrEatments (LONGEVITI) Study
This study looks at how new cancer treatments affect daily life for people with long-term cancer. It aims to understand how to best support them while they are on these treatments, often for many months or years.
Canada - active not recruitingNA
POSNOC - A Trial Looking at Axillary Treatment in Early Breast Cancer
This study, called POSNOC, looks at whether women with early breast cancer and a small number of affected lymph nodes can skip extra armpit surgery or radiotherapy, and just have standard drug treatment. We want to see if this is just as effective.
Australia · New Zealand · United Kingdom