- authorisedTherapeutic exploratory (Phase II)
A multicentre, prospective, open-label study with [68Ga]Ga-ABY-025 PET-imaging to characterize HER2-expression and explore the therapy-predictive value for HER2-antibody drug conjugates in patients with metastatic breast cancer (HER2-Ex PET)
This study looks at a new special scan for breast cancer to see how HER2 protein levels affect treatment. It uses a new drug called Enhertu to treat metastatic breast cancer and aims to find out if the scan can predict how well the treatment will work.
Sweden - active not recruitingPHASE2
KORTUC Phase II - Intra-tumoural Radiation Sensitizer in Patients With Locally Advanced/Recurrent Breast Cancer
This study is testing if a very diluted version of a common chemical, hydrogen peroxide, can make radiotherapy work better for large breast cancer lumps. It involves injecting this special gel into the cancer twice a week during a standard course of radiotherapy. Early results from Japan have been promising.
India · United Kingdom - active not recruitingPHASE3
A Study of Nonsteroidal Aromatase Inhibitors Plus Abemaciclib (LY2835219) in Postmenopausal Women With Breast Cancer
This study looks at a new combination of medicines for postmenopausal women with a certain type of breast cancer. It tests if abemaciclib with standard hormone therapy works better than hormone therapy alone.
United States · Australia · Austria - recruitingPHASE1, PHASE2
A Phase I/II, Dose Finding and Optimization Study of [177Lu]Lu-NeoB in Combination With Capecitabine in Patients With GRPR+, ER+, HER2- Metastatic Breast Cancer After Progression on Previous Endocrine Therapy in Combination With a CDK4/6 Inhibitor.
This study is for people with advanced breast cancer that has grown despite previous treatments. It tests a new combination of targeted radiation therapy and chemotherapy to see if it can stop cancer growth and if it's safe. We're looking at different doses to find the best way to use these treatments.
United States · Australia · Canada - recruitingPHASE1
Study of Orally Administered MOMA-313 in Participants With Advanced or Metastatic Solid Tumors
This early-stage study is testing a new drug, MOMA-313, for advanced solid tumours, including prostate, breast, and pancreatic cancers. It aims to find a safe dose and see how it works, either alone or with another drug called Olaparib, in patients whose tumours have a specific genetic weakness.
United States · Spain · United Kingdom - recruitingPHASE1, PHASE2
A Study to Evaluate the Safety, Tolerability, Drug Levels, and Preliminary Efficacy of BMS-986507 Combinations in Adult Participants With Advanced Solid Tumors
This study is looking at new combinations of medicines for advanced lung or breast cancer. We want to see if they are safe, how much medicine gets into the body, and if they show early signs of working. It's for adults with certain types of advanced cancer.
United States · Australia · Canada - ongoing, recruitingPhase I and Phase II (Integrated)- Other
A Phase 1b/2 Open-Label Study of Samuraciclib in Combination with Elacestrant in Participants with Metastatic or Locally Advanced Hormone-Receptor-Positive and Human Epidermal Growth Factor Receptor 2-Negative Breast Cancer
This study looks at combining two drugs, samuraciclib and elacestrant, for people with advanced breast cancer. It aims to find the best dose and see how well the combination works and if it's safe.
France · Spain - recruitingNA
Biological Matrices Versus Synthetic Meshes
This study looks at two types of mesh used in breast reconstruction after cancer surgery: natural (biological) and man-made (synthetic). It aims to see if patients and doctors are comfortable with not choosing which mesh they get, and to check their long-term safety and how happy people are with the results.
United Kingdom - recruitingPHASE2
To Study the Effect of Inavolisib in Combination With Fulvestrant in Participants With Breast Cancer
This study is looking at a new combination of medicines, Inavolisib and Fulvestrant, for people with a specific type of advanced breast cancer. It aims to see how well this combination works and if it's safe after other treatments haven't worked.
United States · Argentina · Australia - recruitingPHASE4
A Study to Investigate Mechanisms of Resistance to Breast Cancer Therapies
This study looks into why some breast cancers stop responding to treatment. We will examine tissue and blood samples from patients with specific types of breast cancer to understand how the cancer becomes resistant and find new ways to help them.
Belgium · Denmark · Finland - authorisedTherapeutic confirmatory (Phase III)
Assessing Oxytocin's Role in Mitigating Psychosocial Stress in Breast Cancer Survivors
This study looks at whether a nasal spray with a natural hormone called oxytocin can help women who have had breast cancer feel less stressed, anxious, and sad. Researchers will compare it to a dummy spray.
Belgium - active not recruiting
The OPBC-07/microNAC Study
This study looks at whether it's safe to skip a full lymph node removal surgery in breast cancer patients who have only tiny traces of cancer left in their armpit lymph nodes after chemotherapy. It checks how these patients have fared over time.
United States · Argentina · Australia - authorisedPhase I and Phase II (Integrated)- Other
Tumour heterogeneity studies based on dedicated breast PET using proliferation radiotracers: early detection of the treatment response.
This study is looking for better ways to spot early signs if breast cancer treatment is working. It uses a special advanced scan called a PET scan, specifically designed for the breast, to see how fast cancer cells are growing.
Spain - ongoing, recruitingTherapeutic confirmatory (Phase III)
A–BRAVE-Trial. ADJUVANT TREATMENT FOR HIGH-RISK TRIPLE NEGATIVE BREAST CANCER PATIENTS WITH THE ANTI-PD-L1 ANTIBODY AVELUMAB: A PHASE III RANDOMIZED TRIAL
This study is looking at a new treatment called Bavencio for a specific type of breast cancer (triple negative). It's a large study to see if adding Bavencio after initial treatment can help people live longer without their cancer coming back.
Italy - active not recruitingPHASE1, PHASE2
Open-Label Umbrella Study To Evaluate Safety And Efficacy Of Elacestrant In Various Combination In Participants With Metastatic Breast Cancer
This study is testing a new drug called elacestrant with other breast cancer medicines. It's for people with a specific type of advanced breast cancer that has spread. The main goals are to see if these drug combinations are safe and if they can help shrink the cancer.
United States · Argentina · Australia - recruitingPHASE1
A Study of LOXO-783 in Patients With Breast Cancer/Other Solid Tumors
This study is looking into a new medicine, LOXO-783, for breast cancer and other solid tumours with a specific gene change (PIK3CA). It aims to understand if the medicine is safe, what side effects it has, and how well it works.
United States · Australia · Belgium - ongoing, recruitingPhase I and Phase II (Integrated)- Other
Phase I/II study to determine the safety and efficacy of Ribociclib in combination with hormone therapy and hypofractionated radiotherapy in breast cancer, with positive hormone receptors and negative HER2 status, in newly diagnosed, not immediately operable (or wishing to avoid surgery), elderly patient
This study looks at a new way to treat specific breast cancers in older women. It combines a drug called Kisqali with hormone therapy and focused radiotherapy. We want to see if this treatment is safe and effective, especially for patients who can't have or prefer to avoid surgery.
France - active not recruitingPHASE2, PHASE3
A Study Evaluating the Efficacy and Safety of Inavolisib + Palbociclib + Fulvestrant vs Placebo + Palbociclib + Fulvestrant in Participants With PIK3CA-Mutant, Hormone Receptor-Positive, HER2-Negative, Locally Advanced or Metastatic Breast Cancer
This study looks at a new drug, Inavolisib, combined with standard treatments (Palbociclib and Fulvestrant) for a specific type of advanced breast cancer. It compares this new combination to the standard treatments alone, checking how well it works and if it's safe.
United States · Argentina · Australia - active not recruitingPHASE2
Study of Neoadjuvant Olaparib Monotherapy and Olaparib and Durvalumab Combination in HER2 Negative BRCAm Breast Cancer
This study looks at new treatments for a specific type of breast cancer with a BRCA gene change. It tests olaparib, alone or with durvalumab, before surgery. The aim is to find better ways to treat this cancer and reduce the need for strong chemotherapy.
United States · Australia · Austria - active not recruitingPHASE2
Study of Zelenectide Pevedotin in Participants With Advanced Breast Cancer
This study looks at a new drug, zelenectide pevedotin, for advanced breast cancer. It's for people whose cancer has a specific marker called NECTIN4. The study aims to see how well it works and if it's safe for different types of breast cancer.
United States · Australia · Belgium - recruitingNA
Laser Speckle Imaging During Breast Reconstruction
This study looks at a new way to check blood flow during breast reconstruction surgery. It aims to see if a special camera, which doesn’t touch the skin, can help surgeons make better choices and reduce healing problems for women after breast cancer surgery.
United Kingdom - active not recruitingPHASE2
Artificial Intelligence Supporting CAncer Patients Across Europe - the ASCAPE Project
This study uses AI to improve life quality for breast and prostate cancer patients across Europe. It aims to create personalised predictions about challenges patients might face and suggest ways doctors can help, using smart technology and data.
Greece · Spain · Sweden - authorisedTherapeutic confirmatory (Phase III)
A randomized phase III study comparing trastuzumab, pertuzumab plus docetaxel (TPD) followed by 3 cycles of chemotherapy to the current standard regimen as the treatments of early HER2-positive breast cancer
This study looks at a new way to treat early breast cancer that is HER2-positive. It compares a combination of medicines (trastuzumab, pertuzumab, and docetaxel) to the usual treatment to see which is better at preventing the cancer from coming back.
Sweden · Finland - ongoing, recruitingTherapeutic use (Phase IV)
FUnctional selection of advanced breast cancer patients for Talazoparib treatment Using the REpair Capacity (RECAP) test: The FUTURE trial
This study looks at a new test, RECAP, to see if it can predict how well a breast cancer treatment called Talzenna (talazoparib) will work. It focuses on people with advanced breast cancer to find out if the treatment can keep the cancer from growing for at least four months.
Netherlands - recruitingPHASE3
Phase 3 Study of RLY-2608 + Fulvestrant vs Capivasertib + Fulvestrant as Treatment for Locally Advanced or Metastatic PIK3CA-mutant HR+/HER2- Breast Cancer
This study compares two drug combinations, RLY-2608 with fulvestrant, and capivasertib with fulvestrant, for advanced breast cancer that has a specific gene change (PIK3CA mutation) and has grown after previous treatment. It's for HR+/HER2- breast cancer.
United States · Argentina · Australia - active not recruitingPHASE3
A Study Evaluating the Efficacy and Safety of Adjuvant Atezolizumab or Placebo and Trastuzumab Emtansine for Participants With HER2-Positive Breast Cancer at High Risk of Recurrence Following Preoperative Therapy
This study looked at new treatments for HER2-positive breast cancer that had already been treated but still showed signs of cancer after surgery. Researchers wanted to see if adding certain drugs could prevent the cancer from coming back.
United States · Australia · Austria - recruitingPHASE3
A Study Evaluating the Efficacy and Safety of Inavolisib Plus CDK4/6 Inhibitor and Letrozole vs Placebo + CDK4/6i and Letrozole in Participants With Endocrine-Sensitive PIK3CA-Mutated, Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer
This study is looking at a new combination of medicines for a certain type of advanced breast cancer. It compares a new drug, inavolisib, with existing treatments to see if it's more effective and safe for people whose cancer has a specific genetic change (PIK3CA mutation).
United States · Argentina · Australia - active not recruitingPHASE3
Study of PF-07220060 With Letrozole in Adults With HR-positive HER2-negative Breast Cancer Who Have Not Received Anticancer Treatment for Advanced/Metastatic Disease
This study is looking at a new drug, PF-07220060, combined with letrozole for advanced breast cancer. It compares this new treatment to existing approved therapies to see if it's safe and works well for people whose cancer needs hormones to grow.
United States · Argentina · Australia - recruitingNA
Physical Exercise During Preoperative Chemotherapy for Breast Cancer
This study looks at whether regular exercise during chemotherapy for breast cancer can help the treatment work better. It aims to see if exercise helps clear the cancer completely and if it improves patients' well-being during treatment and recovery.
Australia · Finland · Sweden - active not recruiting
The EMBRACE Study The EMBRACE Study
This study looks at how breast cancer chemotherapy affects the heart. Some treatments can weaken the heart. Researchers want to find out if changes in the heart's energy happen before any damage, so they can find ways to protect it early.
United Kingdom - recruiting
The MOMENTUM Study: The Multiple Outcome Evaluation of Radiation Therapy Using the MR-Linac Study
The MOMENTUM Study is tracking how a new type of advanced radiotherapy, called MR-Linac, works for people with different cancers. It aims to see if this treatment improves survival, controls cancer better, and enhances quality of life by using highly precise radiation guidance.
United States · Australia · Belgium - active not recruitingPHASE3
Olaparib as Adjuvant Treatment in Patients With Germline BRCA Mutated High Risk HER2 Negative Primary Breast Cancer
This study looks at a drug called Olaparib for people in the UK with a specific type of breast cancer linked to a BRCA gene change. It aims to see if Olaparib, given after standard treatments, can help prevent the cancer from coming back.
United States · Argentina · Australia - recruiting
Oncologic, Cosmetic and Patient Reported Outcomes in Value-Based Breast Surgery (OnCoPRO Value)
This study looks at breast cancer surgery to improve results for patients. It focuses on how different surgical methods affect cancer outcomes, appearance, and quality of life for women needing breast preservation, aiming for better, more personalised care.
Australia · Sweden · United Kingdom - not yet recruiting
Breast Tumour Size Measurement by Field Cycling Imaging
This study looks at a new type of MRI scan called Field-Cycling Imaging (FCI) to see if it can accurately measure the size of a specific type of breast cancer (DCIS). We want to know if FCI is better than standard methods for sizing these tumours before surgery.
United Kingdom - active not recruitingPHASE2
Basket Study of Entrectinib (RXDX-101) for the Treatment of Patients With Solid Tumors Harboring NTRK 1/2/3 (Trk A/B/C), ROS1, or ALK Gene Rearrangements (Fusions)
This study looks at a drug called entrectinib for different types of advanced cancer. It focuses on cancers with specific genetic changes (NTRK, ROS1, or ALK gene fusions). Researchers want to see if entrectinib can help treat these cancers.
United States · Australia · Belgium - ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
A Study with ABBV-155 Alone and in Combination with Taxane Therapy in Adults with Relapsed and/or Refractory Solid Tumors
This study is testing a new medicine, ABBV-155, by itself and with other cancer drugs called taxanes. It's for adults with certain cancers like lung or breast cancer that have come back or not responded to previous treatments.
Netherlands - not yet recruitingNA
BEAT-Breast: Trial of DE-iPTV in Patients With Primary Breast Cancer With Brain Metastases Who Are Not Suitable for Stereotactic Radiotherapy.
This study looks at a new way to give radiotherapy called DE-iPTV for breast cancer that has spread to the brain. It aims to see if this treatment can be given safely and how it affects patients' quality of life, especially for those who can't have other common treatments.
United Kingdom - recruiting
MIBREAST Making in Immediate Breast REconstruction And the Measurement of the EffectS of RadioTherapy
This study looks at how 3D imaging helps women considering breast reconstruction after mastectomy. It aims to see if it improves confidence, aids surgery planning, and helps us understand how radiotherapy affects reconstructed breasts over time.
United Kingdom - recruitingNA
HERPET- A Novel PET Imaging Study of HER2 in Breast Cancer
This study aims to discover if a new type of scan, using a special tracer called [18F]GE-226, can effectively find and measure a specific protein called HER2 in breast cancer that has spread. We want to find the best time to do this scan and understand how safe it is.
United Kingdom - active not recruiting
Male Breast Cancer: Understanding the Biology for Improved Patient Care
This study looks at breast cancer in men. Researchers are gathering information and samples from men with breast cancer to better understand the disease and improve how it's treated. It's a large international effort to learn more about this rare condition.
United States · Belgium · Brazil - recruitingPHASE2
A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors
This study is looking at a new treatment called HER3-DXd for people with certain advanced solid tumours that haven't responded to other treatments. It aims to see how well it works and if it's safe for different types of cancer, like melanoma, lung cancer, and breast cancer.
United States · Australia · Belgium - active not recruitingPHASE3
A Phase III Randomised Study to Evaluate Dato-DXd and Durvalumab for Neoadjuvant/Adjuvant Treatment of Triple-Negative or Hormone Receptor-low/HER2-negative Breast Cancer
This study is looking at new ways to treat a type of breast cancer that doesn't have certain hormone receptors or HER2 protein, called triple-negative or hormone receptor-low/HER2-negative breast cancer. It tests two different treatment plans using new and existing medicines before and after surgery.
United States · Australia · Austria - recruitingPHASE3
A Study Evaluating the Efficacy and Safety of Inavolisib Plus Fulvestrant Compared With Alpelisib Plus Fulvestrant in Participants With HR-Positive, HER2-Negative, PIK3CA Mutated, Locally Advanced or Metastatic Breast Cancer Post CDK4/6i and Endocrine Combination Therapy
This study looks at two drug combinations, inavolisib with fulvestrant, and alpelisib with fulvestrant, for advanced breast cancer that has specific genetic changes and has already been treated with certain therapies. It aims to see which combination works better and is safer.
United States · Argentina · Australia - active not recruitingPHASE3
A Study of Dato-DXd Versus Investigator's Choice Chemotherapy in Patients With Locally Recurrent Inoperable or Metastatic Triple-negative Breast Cancer, Who Are Not Candidates for PD-1/PD-L1 Inhibitor Therapy (TROPION-Breast02)
This study is looking at a new medicine called Dato-DXd for advanced triple-negative breast cancer. It compares Dato-DXd with standard chemotherapy in patients who cannot have a specific type of immunotherapy. The aim is to see if Dato-DXd is better at shrinking tumours and helping people live longer.
United States · Argentina · Belgium - active not recruitingPHASE3
PALbociclib CoLlaborative Adjuvant Study
This study is looking at whether adding a drug called palbociclib to standard hormone therapy can improve outcomes for people with some types of early breast cancer. It's a large, international study involving many patients.
United States · Australia · Austria - active not recruitingPHASE3
Endocrine Therapy With or Without Abemaciclib (LY2835219) Following Surgery in Participants With Breast Cancer
This study looks at a drug called abemaciclib, given with standard hormone therapy after surgery for a type of breast cancer. We want to see if it's safe and helps stop the cancer coming back in people with certain high-risk breast cancers.
United States · Argentina · Australia - recruitingPHASE3
A Phase III Study of Dato-DXd With or Without Durvalumab Compared With Investigator's Choice of Chemotherapy in Combination With Pembrolizumab in Patients With PD-L1 Positive Locally Recurrent Inoperable or Metastatic Triple-negative Breast Cancer (TROPION-Breast05)
This study looks at new treatments for a type of breast cancer called triple-negative. It compares a new drug, Dato-DXd, sometimes with Durvalumab, against standard chemotherapy with Pembrolizumab for patients whose cancer has come back locally or spread.
United States · Argentina · Australia - not yet recruiting
An Investigation Into Dielectric Testing for the Evaluation and Characterisation of Breast Tissue Using a Novel Time-Domain Bioimpedance Tool
This study is looking at a new device called the ZedScanner. It uses gentle electrical signals to check breast tissue. Researchers want to see if it can safely and accurately tell the difference between healthy, non-cancerous, and cancerous breast tissue. It could help find new ways to detect breast cancer.
United Kingdom - recruiting
Audit of Targeted Sentinel Node Biopsy (TSNB) in Patients With Limited Nodal Disease Undergoing Primary Surgery
This study looks at a new way to remove lymph nodes in breast cancer surgery, called Targeted Sentinel Node Biopsy (TSNB). It helps doctors decide if extra treatment like more surgery or radiotherapy is needed, aiming to reduce side effects.
United Kingdom - active not recruitingPHASE3
Roll Over StudY for Patients Who Have Completed a Previous Oncology Study With Olaparib
This study is for people with ovarian or breast cancer who are already receiving olaparib in a different study and are still benefiting. It allows them to continue getting their treatment if their current study ends, ensuring they keep receiving a medication that is helping them.
United States · Belgium · Bulgaria