A Study to Investigate Mechanisms of Resistance to Breast Cancer Therapies

To join this study, you would generally need to have been diagnosed with HER2-positive, hormone receptor-positive, or triple-negative breast cancer. The doctors would need to be able to safely take a small sample of your tumour (like a biopsy) and a blood sample. You also need to have some existing tumour tissue from a previous diagnosis available for the researchers to look at.

There are two main groups we are looking for. One group includes people whose cancer started to grow again after being on treatment for at least six months. The other group is for people whose cancer is still growing or getting worse even though they have been on treatment for at least four weeks but less than six months.

There are also some reasons why you might not be able to join. For example, if taking a tumour sample would be risky for you (like if you have a bleeding problem), or if you have another serious medical condition that would make it unsafe to take part. Also, if your cancer has already spread to your bones and that's the only place they could take a sample from, you wouldn't be able to join this particular study.

If you decide to take part in this study, the main things you will need to do are:

Firstly, you’ll need to have a procedure to get a small sample of your tumour. This might be a biopsy, where a small piece of tissue is removed, or a slightly larger procedure, depending on what your doctor recommends and what is safest for you.

Secondly, you will have a blood sample taken.

Apart from these sample collections, the study team will also review your medical history and previous scan results. There are no new medications given as part of *this* study. This study is focused on collecting and analysing samples, not on testing new treatments. The exact duration of your involvement will depend on when the samples are collected, usually within four weeks of finishing your last anti-cancer treatment.