- recruitingTherapeutic exploratory (Phase II)
A Multicenter, Randomized, Placebo-Controlled, Parallel Group Trial on the Safety and Efficacy of Istaroxime for Cardiogenic Shock SCAI Stage C (SEISMiC-C)
This study is testing a new medicine, Istaroxime, for people with a serious heart condition called cardiogenic shock. Researchers want to see if it's safe and helps improve blood pressure compared to a dummy medicine. It's an early-stage study to understand its effects better.
Poland · Czechia · Italy - completedNot Applicable
Evaluation of unloading the heart in patients with cardiogenic shock treated with mechanical circulatory support devices
Cardiogenic shock is a life-threatening condition where the heart suddenly fails to pump enough blood. Advanced life-support machines help, but can put extra strain on the heart. This UK study compares two small helper pumps, called IABP and Impella, to discover which one best protects the heart and aids recovery.
United Kingdom - not yet recruitingNA
Feasibility of Protocolised Analgosedation in ECMO
This study looks at whether a special plan for giving painkillers and sedatives (drugs to help you relax) to very sick patients on a life support machine called ECMO could lead to better long-term health. It's testing if such a study is possible to run.
United Kingdom - recruiting
SafeTy and Outcome of contemPorary Treatment Strategies for Cardiogenic SHOCK
This study looks at how people with cardiogenic shock are treated in hospitals today. Researchers want to see which treatments work best, including different medicines, devices, and procedures, to help improve patient outcomes.
Germany - recruiting
Correlation of Cardiac Output Determined by Echocardiography and Indirect Calorimetry in Critically Ill Patients in Cardiogenic Shock on Extracorporeal Circulatory Life Support
This study looks at two ways to measure how well the heart is pumping blood in very sick patients. It compares heart measurements from special scans with measurements from a breathing test to see if they match. This could help doctors get a clearer picture of heart health.
Germany - recruiting
The Clinical and Hemodynamic Course of Cardiogenic Shocks Hospitalized in Critical Care
Doctors are studying people admitted to intensive care for cardiogenic shock, a serious heart condition. They want to see how changes in a patient's blood flow and heart function during their hospital stay are linked to whether they survive. This could help improve care.
France - recruitingNA
Personalisation of Mean Arterial Pressure in Adult Patients With Cardiogenic Shock
This study looks at treating a serious heart condition called cardiogenic shock. We're testing if adjusting blood pressure targets based on individual needs, rather than a standard target, can help patients recover better and improve their chances of survival.
France - recruiting
Genomic Determinants of Outcome in Cardiogenic Shock
This study looks at people with a serious heart condition called cardiogenic shock. Researchers want to understand why some people respond differently to treatments by studying their genes and how their bodies react.
United Kingdom - active not recruiting
Abiomed Impella RT-DAQ - Observational Study
This study is looking at new ways to measure how well the heart is pumping in patients with a serious heart condition called cardiogenic shock. It uses a device called Impella and other sensors to gather information, hoping to find a less invasive way to monitor heart function.
Germany · Italy · Switzerland - active not recruitingNA
Empagliflozin's Microcirculatory Effects in Cardiogenic Shock: an Ancillary Pilot Study of the EMPASHOCK Trial
This study looks at how a drug called empagliflozin affects tiny blood vessels in people with a serious heart condition called cardiogenic shock. We're hoping to understand if it improves blood flow in these tiny vessels, which could help patients recover better.
France - not yet recruitingNA
Pharmacokinetics and Modelling of Beta-Lactam in ECMO-VA Patients
This study looks at how certain antibiotics, called beta-lactams, work in very sick patients on a special life support machine called VA-ECMO. Doctors want to find the best way to give these antibiotics to help fight infections effectively.
France - recruiting
Multimodal Phenotyping In Patients Referred With Acute Cardiac faiLurE
This study looks at hospital information, blood, and urine from adults with serious heart failure. We want to see if this helps doctors understand different types of heart shock and predict patient recovery better. No new treatments are involved.
Germany - active not recruiting
Effect of Early Empagliflozin Initiation in Cardiogenic Shock.
This study looks at whether adding a specific heart medicine, empagliflozin, early to standard care helps people with severe heart failure (cardiogenic shock). We want to see if it reduces deaths and hospital stays after 12 weeks compared to standard care alone.
France - not yet recruitingNA
Efficacy and Safety of Synchronized Cardiac Support in Cardiogenic Shock Patients
This study looks at a special heart support system called Synchronized Cardiac Support (SCS) for people with severe heart failure (cardiogenic shock). It aims to see if SCS, used with a machine called VA ECMO, is safe and helps improve heart function by reducing a chemical called lactate in the blood.
Germany - recruiting
Improving Sedation Practice in Critically Ill Adult Patients Using a Co-designed Sedation Protocol
This study aims to improve how medication for pain and relaxation (sedation) is given to very ill patients on life support (ECMO). We want to create a new guide based on patient, family, and staff experiences to help these patients recover better.
United Kingdom