RecruitingOBSERVATIONAL

Genomic Determinants of Outcome in Cardiogenic Shock

This study is about a life-threatening heart condition called cardiogenic shock. This is when your heart suddenly can't pump enough blood to meet your body's needs. The researchers want to understand why people with cardiogenic shock react differently to the same treatments. They will look at people's genetic information and how their immune system responds. By doing this, they hope to find better ways to treat cardiogenic shock in the future, especially for people who have had a heart attack. This is an observational study, which means people will be carefully monitored, but no new treatments will be tested.

At a glance

Status

Recruiting

Sponsor

Barts & The London NHS Trust

Enrolment target

300

Start

08 Aug 2022

Estimated completion

31 Dec 2026

Cardiogenic Shock

What is this study about?

Imagine your heart is a pump, working hard to send blood all over your body. Sometimes, after a severe heart attack or other serious heart problems, this pump suddenly struggles and can't send enough blood. This is called cardiogenic shock, and it's a very serious condition where your body's organs don't get the oxygen they need. Doctors often use different treatments and machines to help the heart recover, but sometimes these treatments work better for some people than for others.

This study aims to understand why there are these differences in how people respond to treatment. Researchers believe that tiny differences in our genes (our body's instruction manual) and how our immune system reacts might play a big role. By looking closely at these factors in people with cardiogenic shock, they hope to find clues. For example, they might discover certain genetic patterns or immune reactions that predict which treatments will be most effective for different individuals.

The ultimate goal of this research is to improve how doctors care for people with cardiogenic shock. By gaining a deeper understanding of these differences, scientists hope to pave the way for more personalised and effective treatments in the future. This could mean that doctors might one day be able to choose the best treatment for you based on your unique body, rather than a more general approach.

Key takeaways

Study aims to understand individual differences in cardiogenic shock.
It's an observational study; no new treatments are given.
Information gathered could lead to better future treatments.
Participation involves monitoring and collection of samples like blood.
You can withdraw from the study at any time without affecting your care.

Who may be eligible?

This study is looking for people who have recently had a heart attack and also developed a severe heart condition called cardiogenic shock. This means your blood pressure is very low, and your body isn't getting enough blood, leading to noticeable symptoms like confusion or very cold skin. You must have had your heart attack symptoms start within the last 24 hours and have had treatment to unblock your heart artery.

They are also looking for a smaller group of people who developed cardiogenic shock due to other heart conditions, like inflammation of the heart muscle (myocarditis). Additionally, some people who had a heart attack but *didn't* develop cardiogenic shock might be included, to help compare information.

There are also some reasons why you wouldn't be able to join. For example, if you're under 18 or over 80, or if your cardiogenic shock was caused by something other than a heart attack or myocarditis, like a severe infection (sepsis) or major bleeding. You also couldn't join if you have certain other serious illnesses, advanced dementia, or if doctors don't expect you to live for at least another 12 months. Everyone needs to be able to understand and agree to take part, or have someone legally appointed to agree for them.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Have I recently had a heart attack and also developed cardiogenic shock?
Did my heart attack symptoms start in the last 24 hours?
Have I had treatment to unblock my heart artery?
Am I between 18 and 80 years old?
Am I able to understand and agree to take part, or is there an appointed person who can?
My cardiogenic shock is not caused by a severe infection or major bleeding.

Answer every question to see your result.

What does participation involve?

If you decide to take part in this study, it's considered an "observational study." This means doctors will monitor your condition very closely and collect detailed information about your health, your treatment, and how you respond. You won't be given any new or experimental medications or treatments as part of the study itself; you'll receive the standard care your doctors would normally provide. Throughout the study, various samples, such as blood, will be taken at different times to help researchers understand your genetic information and immune responses. The exact number of visits and the full duration of your participation would be explained in detail by the study team, as it would depend on your individual medical situation and recovery.

Potential risks and benefits

The main benefit of taking part in this study is that you would be contributing to valuable research that could lead to better treatments for cardiogenic shock in the future. While you won't receive a direct benefit from participating, the information gathered from people like you is crucial for scientific understanding. The risks involved are generally low, mainly related to the standard medical procedures you would already be undergoing, such as blood tests. Any discomfort from blood draws would be temporary. Remember, you have the right to withdraw from the study at any time, for any reason, without it affecting your medical care.

Locations (1)

Some site locations are approximate. We're improving this — please verify with the trial team before travelling.

Barts Health NHS trust
Verified postcode
London, United Kingdom· Recruiting

Common questions

What is cardiogenic shock?

It's a serious condition where your heart suddenly can't pump enough blood to your body, often after a severe heart attack.

What does 'observational study' mean?

It means doctors will closely watch your health and collect information, but you won't receive any new study treatments; you'll get standard care.

Will I be given any new medicines?

No, this study doesn't test new medicines. You will receive the usual care and treatments your doctors recommend.

How long will I be in the study?

The study team will explain the exact duration, which depends on your individual health journey and recovery.

Can I leave the study at any time?

Yes, you have the right to withdraw from the study at any point, and it won't affect your medical care.

How to find out more

Alastair Proudfoot

alastair.proudfoot1@nhs.net 02037658707 Official trial record

Always speak to your GP or specialist before deciding to take part in a study.