- ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
A study to Evaluate AB308 in Combination with AB122 in Participants with Advanced Malignancies (ARC-12)
This early-stage study is testing a new combination of medicines, AB308 and AB122, for people with several types of advanced cancer, including blood cancers and solid tumours. It aims to see if the treatment is safe and how the body reacts to it.
Spain · Poland - ongoing, recruitingTherapeutic confirmatory (Phase III)
Phase III, randomized, double-blind, placebo-controlled, multicenter study to evaluate the efficacy of pre-surgical HPV9-valente vaccination in women treated with loop electrosurgical excision (LEEP) for high-grade cervical intraepithelial neoplasia (CIN2+) up to cervical cancer initially invasive (FIGO IA1) - HOPE 9 STUDY
This study looks at whether a special HPV vaccine, Gardasil 9, can help prevent cervical cell changes from coming back in women who've had surgery. It compares vaccinated women to those who received a dummy treatment.
Italy - active not recruitingPHASE3
A Study to Compare Sacituzumab Tirumotecan (MK-2870) Monotherapy Versus Treatment of Physician's Choice as Second-line Treatment for Participants With Recurrent or Metastatic Cervical Cancer (MK-2870-020/TroFuse-020/Gog-3101/ENGOT-cx20)
This study compares a new treatment called Sacituzumab Tirumotecan with standard care for recurrent or metastatic cervical cancer. It aims to see if the new treatment improves how long people live when current treatments aren't enough.
United States · Argentina · Australia - recruitingPHASE1
ASTEROID: A Trial of ASTX660 in Combination With Pembrolizumab
This study is testing a new combination of two drugs, ASTX660 and pembrolizumab, for people with advanced cancers like cervical cancer and a type of breast cancer. It's a first step to see if this new approach can boost the body's own immune system to fight cancer.
United Kingdom - active not recruitingPHASE2
A Phase II Clinical Trial of Cediranib and Olaparib Maintenance in Advanced Recurrent Cervical Cancer
This study looks at new drug combinations (Cediranib and Olaparib) for women with advanced cervical cancer that has come back. It aims to see if these drugs can stop the cancer from growing for longer after their initial chemotherapy treatment.
United Kingdom - active not recruiting
Biomarkers for Clinical Hypoxia Evaluation in Cervical Cancer
This study looks at new ways to predict how well treatments work for locally advanced cervical cancer. We aim to find better clues (biomarkers) from tumour samples and MRI scans to help doctors choose the best treatment for each patient, improving their chances of recovery.
United Kingdom - recruitingPHASE1
A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors
This study is testing a new drug, LY4052031, for people with advanced cancers like bladder, breast, and lung cancer. It aims to see if the drug is safe, what dose works best, and if it helps shrink tumors. It's an early-stage study to gather important information.
United States · Australia · China - not yet recruitingNA
EQUITA - A Feasibility Trial of a Faith-placed Intervention to Increase Screening Uptake in Black Adults
This study looks at how faith groups can help Black adults get important cancer and aneurysm screenings. It's a small trial in the North East, Leeds, and Scotland to see if this approach works and is well-received before a larger study.
United Kingdom - recruitingPHASE1
A Study of NX-1607 in Adults With Advanced Malignancies
This study is looking into a new treatment called NX-1607 for various advanced cancers, including ovarian, stomach, and lung cancer. It aims to see how safe the treatment is and if it can help fight the cancer, sometimes combined with another drug called Paclitaxel.
United States · United Kingdom - ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
A Phase 1 Study of SGN-ALPV in Advanced Solid Tumors
This early-stage study is testing a new treatment called SGN-ALPV for advanced solid cancers, including certain stomach, lung, and gynaecological cancers. It's looking closely at how safe the treatment is and what side effects it might cause when first given to people.
Spain · Sweden · Netherlands - ongoing, recruitingHuman Pharmacology (Phase I)- Other
ImmunoTHerapy Adjacent to Cervical CAncer (ITHACA) study: safety, toxicity and immunological effects of peritumorally delivered immunotherapy in early-stage cervical cancer
This study is looking at a new way to treat early cervical cancer. It's testing a new medicine that aims to boost the body's own immune system to fight cancer, given directly into or near the tumour. Researchers want to see if it's safe and how it affects the body.
Netherlands - ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
A Phase 1 open-label, first-in-human, multi-center, dose escalation and dose expansion study of CLN-619 administered alone or in combination with pembrolizumab in patients with advanced solid tumors.
This study is testing a new medicine, CLN-619, for people with advanced cancers like lung, cervical, or breast cancer. It's the first time this medicine is being given to people, either alone or with another drug called pembrolizumab, to see if it's safe and how much to give.
Spain · Poland - active not recruitingPHASE1, PHASE2
Study of AZD5305 as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Malignancies
This study is looking into a new drug, AZD5305, by itself or with other cancer treatments, for advanced solid cancers like ovarian, breast, and lung cancer. It aims to see if it's safe, tolerable, and effective.
United States · Australia · Canada - recruitingPHASE1
A Study of MGC026 in Participants With Advanced Solid Tumors
This study is testing a new medicine called MGC026 for people with advanced cancers that have come back or spread. Doctors want to see if it's safe, what side effects it causes, and if it can help slow down or shrink tumors.
United States · Australia · United Kingdom - recruitingPHASE2
A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors
This study is looking at a new treatment called HER3-DXd for people with certain advanced solid tumours that haven't responded to other treatments. It aims to see how well it works and if it's safe for different types of cancer, like melanoma, lung cancer, and breast cancer.
United States · Australia · Belgium - active not recruitingPHASE3
Induction Chemotherapy Plus Chemoradiation as First Line Treatment for Locally Advanced Cervical Cancer
This study looks into adding a short course of chemotherapy (Paclitaxel and Carboplatin) before standard chemoradiation for women with locally advanced cervical cancer. The aim is to see if this extra step improves how long women live and if the cancer stays away.
Brazil · India · Italy - recruitingPHASE1
A Study to Evaluate the Safety, Tolerability, Preliminary Efficacy of KRC-01
This study is looking into a new treatment called KRC-01 for cervical cancer. It aims to see if KRC-01 is safe, if patients can tolerate it, and if it helps shrink tumours when used with standard treatments like radiotherapy and chemotherapy.
India · Thailand · United Kingdom - active not recruitingPHASE1, PHASE2
A Phase I/IIa Trial of HMBD-001 in Advanced HER3 Positive Solid Tumours
This study is testing a new drug, HMBD-001, for advanced cancers where a protein called HER3 is active. We want to find the best dose, understand side effects, and see if it helps stop cancer growth, sometimes with another drug called enzalutamide.
United Kingdom