- recruitingTherapeutic confirmatory (Phase III)
Phase III, randomized, double-blind, placebo-controlled, multicenter study to evaluate the efficacy of pre-surgical HPV9-valente vaccination in women treated with loop electrosurgical excision (LEEP) for high-grade cervical intraepithelial neoplasia (CIN2+) up to cervical cancer initially invasive (FIGO IA1) - HOPE 9 STUDY
This study looks at whether a special HPV vaccine, Gardasil 9, can help prevent cervical cell changes from coming back in women who've had surgery. It compares vaccinated women to those who received a dummy treatment.
Italy - recruitingPHASE2
A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors
This study is looking at a new treatment called HER3-DXd for people with certain advanced solid tumours that haven't responded to other treatments. It aims to see how well it works and if it's safe for different types of cancer, like melanoma, lung cancer, and breast cancer.
United States · Australia · Belgium - recruitingPHASE3
A Clinical Study of Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) as First-line Maintenance Treatment of Cervical Cancer (MK-2870-036/TroFuse-036/GOG-3123/ENGOT-cx22)
This study is for women with cervical cancer that has spread. It's testing new combinations of medicines (sac-TMT, pembrolizumab, and possibly bevacizumab) to see if they are safe and can help people live longer or stop their cancer from getting worse.
United States · Argentina · Austria - recruitingHuman Pharmacology (Phase I)- Other
ImmunoTHerapy Adjacent to Cervical CAncer (ITHACA) study: safety, toxicity and immunological effects of peritumorally delivered immunotherapy in early-stage cervical cancer
This study is looking at a new way to treat early cervical cancer. It's testing a new medicine that aims to boost the body's own immune system to fight cancer, given directly into or near the tumour. Researchers want to see if it's safe and how it affects the body.
Netherlands - recruitingPHASE1
A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors
This study is testing a new drug, LY4052031, for people with advanced cancers like bladder, breast, and lung cancer. It aims to see if the drug is safe, what dose works best, and if it helps shrink tumors. It's an early-stage study to gather important information.
United States · Australia · China - recruitingNA
FIGO 2018 Stage IB2 Cervical Cancer Treated With Neoadjuvant Chemotherapy Followed by Fertility Sparing Surgery
This study looks at treating cervical cancer with chemotherapy before surgery to help women keep their fertility. It compares this approach to surgery alone, aiming to reduce long-term side effects like infertility while effectively treating the cancer.
United States · Canada - not yet recruitingPHASE2
Hyperthermia Enhanced Re-irradiation of Loco-regional Recurrent Tumors
This study looks at using heat treatment (hyperthermia) with repeat radiation therapy for certain cancers that have come back after earlier radiation. It checks if this combined approach works as well as the first treatment for preventing the cancer from returning locally.
Germany - recruitingNA
German-funded Laparoscopic Approach to Cervical Cancer
This study compares two types of surgery for early cervical cancer: keyhole (laparoscopic/robotic) versus traditional open surgery. It wants to see if keyhole surgery is just as good at preventing the cancer from coming back, with a focus on patients with smaller tumours.
Germany - active not recruitingPHASE1
ASTEROID: A Trial of ASTX660 in Combination With Pembrolizumab
This study is testing a new combination of two drugs, ASTX660 and pembrolizumab, for people with advanced cancers like cervical cancer and a type of breast cancer. It's a first step to see if this new approach can boost the body's own immune system to fight cancer.
United Kingdom - recruitingPHASE1
A Study of NX-1607 in Adults With Advanced Malignancies
This study is looking into a new treatment called NX-1607 for various advanced cancers, including ovarian, stomach, and lung cancer. It aims to see how safe the treatment is and if it can help fight the cancer, sometimes combined with another drug called Paclitaxel.
United States · United Kingdom - recruitingNA
FDG-PET and Circulating HPV in Patients With Cervical Cancer Treated With Definitive Chemoradiation (II)
This study looks at how well special scans and blood tests can find cervical cancer cells after treatment. It aims to see if these tests can predict how well patients will do and if the cancer might come back. Patients will get standard treatment.
Canada - recruitingNA
Using Artificial Intelligence-based ChatBot to Improve Women's Participation to Cervical Cancer Screening Programme
This study aims to make it easier for women to get screened for cervical cancer in France. It uses a special online chatbot to provide information and support, especially for women who haven't had a recent screening or have less schooling, to encourage them to use home testing kits.
France - recruitingNA
Screening for Anal Cancer in Women With High-grade Vulvar Dysplasia or Vulvar Cancer.
This study looks at whether women over 40 with certain vulvar conditions are at higher risk for anal cancer. It aims to see if regular anal screening, like a Pap test for the bottom, could help find and treat problems early in this group.
Canada - recruiting
Therapeutic Abstention and Surveillance of Intra-epithelial Histological Lesions of High Grade Cervical CIN2 (Cervical Intraepithelial Neoplasia Grade 2). SUIVICIN
This study looks at whether regular checks instead of immediate treatment can be safe for women aged 18-39 with a mild cell change called CIN2. It aims to see if CIN2 can clear up on its own over two years, avoiding surgery and its potential downsides.
France - recruitingPHASE1, PHASE2
A Study of BMS-986340 as Monotherapy and as Combination Therapy in Participants With Advanced Solid Tumors
This study is testing a new drug, BMS-986340, by itself and with other treatments for different advanced cancers. Researchers want to find the safest dose and see how well it works. This is the first time BMS-986340 has been tried in people.
United States · Australia · Canada - not yet recruitingPHASE2
Adaptive Radiotherapy for Safe Hypofractionation
This study compares a new, more flexible way of giving radiotherapy called 'adaptive radiotherapy' with the standard treatment for certain cancers. It aims to see if this new method, which uses fewer, stronger doses, is just as safe and effective.
Canada - recruitingNA
A Trial of Robotic Versus Open Hysterectomy Surgery in Cervix Cancer
This study compares two types of surgery for early-stage cervical cancer: 'keyhole' surgery using a robot and traditional open surgery. We want to see if both are equally good at helping patients stay cancer-free.
United States · Canada - active not recruitingNA
Impact of an Educational Physiotherapy-Yoga Intervention on Perceived Stress in Women Treated With Brachytherapy for Cervical Cancer
This study looks at how a special Kine-Yoga programme, which includes education, might help women with cervical cancer feel less stressed during and after brachytherapy treatment. It aims to improve their well-being.
France - recruiting
Evaluation of Salivary RNA in Subjects Scheduled for Surgery for a Gynecologic Pathology
This study looks for clues in your spit to help diagnose common gynaecological problems like endometriosis, ovarian cysts, and cancers. It aims to find new ways to spot these conditions by examining special genetic material (RNA) in saliva.
France - recruitingPHASE1
A Study of MGC026 in Participants With Advanced Solid Tumors
This study is testing a new medicine called MGC026 for people with advanced cancers that have come back or spread. Doctors want to see if it's safe, what side effects it causes, and if it can help slow down or shrink tumors.
United States · Australia · United Kingdom - not yet recruitingNA
EQUITA - A Feasibility Trial of a Faith-placed Intervention to Increase Screening Uptake in Black Adults
This study looks at how faith groups can help Black adults get important cancer and aneurysm screenings. It's a small trial in the North East, Leeds, and Scotland to see if this approach works and is well-received before a larger study.
United Kingdom - active not recruitingPHASE1, PHASE2
Study of AZD5305 as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Malignancies
This study is looking into a new drug, AZD5305, by itself or with other cancer treatments, for advanced solid cancers like ovarian, breast, and lung cancer. It aims to see if it's safe, tolerable, and effective.
United States · Australia · Canada - active not recruitingPHASE1, PHASE2
A Phase I/IIa Trial of HMBD-001 in Advanced HER3 Positive Solid Tumours
This study is testing a new drug, HMBD-001, for advanced cancers where a protein called HER3 is active. We want to find the best dose, understand side effects, and see if it helps stop cancer growth, sometimes with another drug called enzalutamide.
United Kingdom - active not recruitingPHASE3
A Study to Compare Sacituzumab Tirumotecan (MK-2870) Monotherapy Versus Treatment of Physician's Choice as Second-line Treatment for Participants With Recurrent or Metastatic Cervical Cancer (MK-2870-020/TroFuse-020/Gog-3101/ENGOT-cx20)
This study compares a new treatment called Sacituzumab Tirumotecan with standard care for recurrent or metastatic cervical cancer. It aims to see if the new treatment improves how long people live when current treatments aren't enough.
United States · Argentina · Australia - active not recruitingPHASE3
Induction Chemotherapy Plus Chemoradiation as First Line Treatment for Locally Advanced Cervical Cancer
This study looks into adding a short course of chemotherapy (Paclitaxel and Carboplatin) before standard chemoradiation for women with locally advanced cervical cancer. The aim is to see if this extra step improves how long women live and if the cancer stays away.
Brazil · India · Italy - recruitingPHASE1
A Study to Evaluate the Safety, Tolerability, Preliminary Efficacy of KRC-01
This study is looking into a new treatment called KRC-01 for cervical cancer. It aims to see if KRC-01 is safe, if patients can tolerate it, and if it helps shrink tumours when used with standard treatments like radiotherapy and chemotherapy.
India · Thailand · United Kingdom - active not recruitingPHASE2
A Phase II Clinical Trial of Cediranib and Olaparib Maintenance in Advanced Recurrent Cervical Cancer
This study looks at new drug combinations (Cediranib and Olaparib) for women with advanced cervical cancer that has come back. It aims to see if these drugs can stop the cancer from growing for longer after their initial chemotherapy treatment.
United Kingdom - active not recruiting
Biomarkers for Clinical Hypoxia Evaluation in Cervical Cancer
This study looks at new ways to predict how well treatments work for locally advanced cervical cancer. We aim to find better clues (biomarkers) from tumour samples and MRI scans to help doctors choose the best treatment for each patient, improving their chances of recovery.
United Kingdom