Evaluation of Salivary RNA in Subjects Scheduled for Surgery for a Gynecologic Pathology

You might be able to take part if you are an adult woman, aged 18 or over. You need to be insured for medical care and understand and sign a consent form.

You could be eligible if you are having symptoms (like bleeding or pain) and are scheduled for surgery or a biopsy for conditions such as endometriosis, ovarian cysts, fibroids, or cancers of the ovary, cervix, or womb. You might also be included if you don't have symptoms but have had an abnormal cervical screening test (Pap smear) or if you are having a routine cervical screening as part of your gynaecological check-up. The key is that you haven't yet had surgery or other treatments like chemotherapy or radiotherapy for these conditions.

There are also some reasons why you might not be able to join. These include having a recent infection, active mouth or digestive fungal infections, certain ongoing mouth problems, being pregnant, or having other non-gynaecological problems in your pelvis. If you have a different type of cancer (other than some skin cancers) or have been treated for cancer in the last five years, you won't be able to join. Also, if you have difficulty reading or writing, or are already part of another drug trial, you wouldn't be able to take part.

If you decide to take part, your involvement will be very straightforward. You will be asked to provide a saliva sample. This happens during a routine visit you are already making to your gynaecology or gynaecological oncology department, often when you are scheduled for surgery or a biopsy. Importantly, participation will not change your planned medical care, specialist appointments, or any treatments your doctor has recommended. Your care pathway remains exactly the same. There are no additional medications, extra doctor visits, or follow-up procedures specifically for this study. The total duration of your participation is essentially limited to the time it takes to provide the saliva sample.