- recruitingHuman Pharmacology (Phase I)- Other
Research into new test methods to measure pain with two existing drugs (nefopam and oxycodone)
Researchers are looking into new ways to measure pain. This study will test two existing pain relief medicines, nefopam and oxycodone, to see how well these new measurement methods work. It's for adults with long-term pain and is one of the first steps in testing.
Netherlands - completed
Developing and testing a way to correctly identify people with chronic pain from their primary care records
Researchers in Scotland are testing a computer tool to identify people living with chronic pain using GP records. By comparing medical files with patient surveys and interviews, the study aims to give the NHS accurate figures, helping planners design better pain services and improve everyday care across the country.
United Kingdom · Scotland - recruitingHuman Pharmacology (Phase I)- Other
A randomized, double-blind, double dummy, placebo-controlled, four-way cross-over study to investigate the analgesic effects and CNS effects of morphine and fluvoxamine in healthy subjects.
This study is looking at how two medications, morphine and fluvoxamine, affect pain and the brain in healthy adults. It's an early-stage study to understand how these drugs work, especially when given together.
Netherlands - enrolling by invitationNA
Pain-at-Work Toolkit (Definitive Trial)
This study is testing an online toolkit to help people in the UK manage long-term pain at work. It aims to boost confidence, provide support, and improve their work experience so they can stay in their jobs.
United Kingdom - not yet recruitingNA
Virtual Reality and Cranial Nerve Neuromodulation to Manage Chronic Pain
This study looks at using virtual reality (VR) and a new tongue stimulation method (Cranial Nerve Neuromodulation) to help Canadian military veterans with long-lasting pain and PTSD. It aims to see if combining these treatments works better than VR alone.
Canada - active not recruitingNA
The Effect of Physiotherapy Integrated With Yoga and Mindfulness on Individuals With Fibromyalgia
This study looks at a new program called PhYoMind for people with fibromyalgia. It combines special exercises, yoga, and mindfulness to see if it helps with pain, tiredness, and overall well-being. Participants will either do PhYoMind or a home exercise routine for 8 weeks.
Germany - active not recruitingNA
IPRP Repeated Transcranial Magnetic Stimulation (rTMS)
This study looks at combining a special rehabilitation program with a gentle brain stimulation technique for young people with long-lasting pain. It aims to see if this combination can help reduce pain and improve their mental well-being and daily life.
Canada - recruitingNA
Neurosensorial Disorder and Pain in Oral Cavity and Oropharynx Cancer Traited Patients (OCAPA)
This study looks at nerve problems and pain in people who have had treatment for mouth and throat cancer. It aims to understand these issues better by mapping them out and seeing how they affect patients.
France - active not recruiting
Long-term Effectiveness, Safety, and Performance of the Evoke Closed-Loop SCS System to Treat Patients With Chronic Pain of the Trunk and/or Limbs
This study looks at how well the Evoke Spinal Cord Stimulation (SCS) system works in the long term for people with ongoing body or limb pain. Researchers want to see how safe and effective it is in everyday life for managing chronic pain.
Belgium · Germany · Netherlands - enrolling by invitation
Pain Science Education for Labour and Postpartum Pain
This study brings together experts to create better ways to teach pregnant women about pain, especially during and after labour. It aims to help develop new tools to manage pain, reduce fear, and support wellbeing.
United Kingdom - recruitingPHASE2
Novel Use of Probenecid to Alleviate Symptoms of Opioid Withdrawal
This study is looking at a medicine called probenecid to help people reduce the difficult symptoms they experience when trying to cut down or stop opioid pain medication. Researchers want to see if probenecid can make it easier for patients to manage chronic pain without strong opioids.
Canada - recruiting
Observational Study of the Use of 8% Capsaicin Patch in Children 0 to 18 Years Old
This study looks at how children and teenagers with long-lasting nerve pain get on when treated with an 8% capsaicin patch. Doctors want to understand how well it works and whether it causes any problems, by collecting information from patients and their families.
France - not yet recruitingNA
Dance-therapy and Chronic Pain
This study explores how dance therapy might help young people aged 12-20 with long-lasting pain like chronic headaches or Complex Regional Pain Syndrome. It aims to see if moving and expressing themselves through dance can reduce pain, fear of movement, and anxiety, ultimately improving their well-being.
France - recruitingPHASE2
Treatment With Psilocybin for Chronic Neuropathic Pain and Depression (TRANSCEND)
This study is exploring if a single dose of psilocybin, a compound from 'magic mushrooms,' could help people aged 18-65 with tough-to-treat depression and ongoing nerve pain. Researchers want to see if it's safe, and if it makes a difference to their symptoms.
Canada - active not recruitingPHASE4
Intraoperative Sufentanil and Chronic Postsurgical Pain in Non-major Scheduled Abdominal Surgery
This study looks at whether a pain medicine called sufentanil, given during common tummy operations, might affect long-term pain. We want to see if there's a link between how much sufentanil is given in surgery and if patients feel ongoing pain three months later.
France - recruitingNA
Music Intervention in Chronic Pain Patients
This study looks at whether listening to music can help people who live with ongoing pain. Researchers want to see if personalised music sessions can reduce pain, anxiety, and make people feel better overall, compared to not having music sessions.
Canada - recruitingNA
Reducing Opioid Use for Chronic Pain Patients Following Surgery
This study looks at a new program helping people with long-term pain who take strong painkillers (opioids) after surgery. It aims to reduce how many opioids they use while still managing their pain, using education, therapy, and a self-management app.
Canada - recruiting
DEterminants of Decisional Autonomy In Chronic Pain Patients and Assessment of Treatment Effectiveness
This study looks at how people with ongoing pain make decisions about their treatment. It aims to understand what helps or hinders their choices and how this affects their recovery. Researchers will use a special tool to measure decision-making abilities.
France - active not recruitingNA
Patient Education, Self-management and Physiotherapy for Chronic Temporomandibular Disorders
This study compares two ways to help with long-lasting jaw pain (TMD): simple home exercises with education, or standard physiotherapy with hands-on care. Researchers want to see which one works better to reduce pain and improve daily life for adults aged 18-65.
Canada - recruiting
Pain Clinic Provides Public Health Safety
This study looks at how pain clinics help adults aged 20-99 with long-lasting pain and other problems. We want to see if managing pain can improve their health, social life, money situation, and jobs, helping them feel better all round and improve public safety.
Canada - recruiting
Cohort of Chronic Pain Patients
This study is looking into new ways to help people with ongoing pain. It uses a smartphone app called e-DOL to track how pain affects daily life and to help healthcare professionals understand and support patients better. The aim is to improve pain management for many people.
France - active not recruitingPHASE2, PHASE3
Evaluating the Efficacy of Intranasal Oxytocin on Chronic Pain
This study looks at whether a nasal spray with oxytocin can help people with long-lasting pain. Oxytocin is a natural body chemical. We want to see if different doses can reduce pain and improve daily life more than a dummy spray.
Canada - recruitingNA
Comparison of the Efficacy of an Empowered Relief Single-Session Versus Standard Care for Reducing Postoperative Pain Following Elective Orthopedic Surgery: A Randomized Controlled Trial
This study compares a new pain management class called Empowered Relief (ER) with standard care for people having orthopaedic surgery. We want to see if ER helps reduce pain and improves recovery after an operation, especially for those with long-term pain before surgery.
Canada - active not recruiting
Implementation and Evaluation of a Stepped-Care Mental Health Treatment Program for Patients With Chronic Pain
This study looks at a new way to help people in Canada with long-term pain who also have mental health issues or problems with substance use. It uses online workshops and group sessions to give support and teach coping skills, especially since the COVID-19 pandemic has made things harder for these individuals.
Canada - recruiting
Patient Retrospective Outcomes (PRO)
This study looks back at anonymous medical records of adults with long-lasting pain. It compares how well different treatments worked, including those from Boston Scientific, to help doctors understand what works best for patients.
United States · Australia · Belgium - recruitingPHASE2
Perioperative Vitamin C to Reduce Persistent Pain After Total Knee Arthroplasty
This study is looking at whether Vitamin C can help reduce long-lasting pain after knee replacement surgery. It's a small, early-stage trial comparing Vitamin C to a dummy pill to see if a bigger study should be done in the future.
Canada - enrolling by invitation
Distress in Adolescents With Chronic Pain: Who is at Risk, When, and Why
This study looks at why some young people with ongoing pain also feel very distressed. Researchers want to understand who is most at risk and when, so they can help at the right time. 70 young people will share their feelings and pain experiences for 30 days.
United Kingdom - not yet recruiting
Chronic Pain Predictors in Major Trauma
This study looks at why some people with severe injuries and broken bones develop long-term pain. Researchers want to find out what puts people at risk of this pain up to six months after their injury.
United Kingdom - recruitingNA
Whole-Body Photobiomodulation and Chronic Pain Trial
This study looks into a new, gentle light therapy for long-lasting pain. It's called whole-body photobiomodulation. We want to see if it's a good and helpful option for people dealing with chronic pain, reducing pain, inflammation, and helping with recovery.
United Kingdom - recruiting
Long-Term Real-World Outcomes Study on Patients Implanted With a Neurostimulator
This study looks at how well special devices called neurostimulators work for people with long-term pain. Researchers want to see if these devices are safe and effective over time in everyday situations.
United States · Australia · Belgium