- recruitingPhase III
A study of JNJ-78934804 in participants with moderately to severely active Crohn's disease
This clinical trial is testing a new combination medicine, JNJ-78934804, for moderate to severe Crohn’s disease. It combines two drugs into one injection to target gut inflammation. Researchers want to see if this two-in-one approach works better than a single medicine for people whose previous treatments have stopped working.
United Kingdom · England · Northern Ireland - recruitingTherapeutic exploratory (Phase II)
A Phase 2, multinational, multicenter, randomized, double blind, placebo controlled, dose-ranging study to evaluate the efficacy and safety of SAR441566 in adults with moderate to severe Crohn’s disease.
This clinical study tests a new medicine called balinatunfib (SAR441566) for adults with moderate to severe Crohn's disease. Researchers want to see if different doses help heal the bowel lining and reduce symptoms compared to a dummy treatment (placebo), while checking for any unwanted side effects.
Hungary · Spain · France - recruitingPhase III and phase IV (Integrated)
An Open-Label Extension and long-term efficacy and safety monitoring study of patients with Crohn's disease previously included in the loss of RESponse to Ustekinumab treated by dose Escalation study (REScUE-OLE)
This study looks at how well a medicine called Stelara works for Crohn's disease over a long time. It checks if people can stay well without steroids and how safe the medicine is for patients who have been in a previous study.
Belgium - recruitingHuman Pharmacology (Phase I)- Other
PET study of changes in [11C]AZ14132516 uptake following administration of multiple AZD7798 doses to patients with Crohn’s disease.
This study is looking at how a new medicine, AZD7798, affects the bodies of people with Crohn's disease. Researchers will use special scans to see if the medicine changes the way a certain marker called [11C]AZ14132516 appears in the body after receiving several doses.
Sweden - recruitingTherapeutic exploratory (Phase II)
A Phase 2a, Multi-Center, Open-Label Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of PRA023 in Subjects with Moderately to Severely Active Crohn’s Disease
This study is looking at a new medicine called tulisokibart for people with Crohn's disease. We want to see if it's safe, how well it works, and how the body handles it. It's an early-stage study to understand its potential.
France · Poland · Czechia - recruitingPhase II and Phase III (Integrated)
C5041006 (APD334 202 or APD334-202EU): A Multicenter, Randomized, Double Blind, Parallel Group Study to Assess the Efficacy and Safety of Oral Etrasimod as Induction and Maintenance Therapy for Moderately to Severely Active Crohn’s Disease
This study is testing a new medicine called etrasimod for people with moderate to severe Crohn's disease. Researchers want to see if it helps improve symptoms and gut health, and if it is safe to use.
Austria · Denmark · Poland - recruitingTherapeutic use (Phase IV)
A Prospective Multicenter Randomized Controlled, Open-label Study to Compare the Efficacy of Subcutaneous Infliximab Monotherapy with Subcutaneous Infliximab and Concomitant Immunosuppression in the Treatment of Moderate to Severe Crohn’s Disease ( Direct-CD)
This study looks at treating Crohn's disease with a medicine called Remsima given by injection under the skin. It compares giving Remsima alone versus Remsima with another medicine. The goal is to see which approach works best to reduce symptoms and heal the gut.
Netherlands - recruitingPhase I and Phase II (Integrated)- Other
Treatment of refractory Crohn's disease lesions by local injection of mesenchymal stem cells
This study is testing a new treatment using special cells called mesenchymal stem cells (MSCs) for people with Crohn's disease whose usual treatments haven't fully worked. Doctors will carefully inject these cells into affected areas to see if they help heal the problem and if the treatment is safe.
Belgium - recruitingTherapeutic confirmatory (Phase III)
Evaluation of the efficacy of topical treatment with budesonide in children with Crohn's disease located in the esophagus and/or stomach and/or duodenum - BETHESDa
This study, called BETHESDa, is looking into how well a medicine called budesonide works for children with Crohn's disease that affects their food pipe, stomach, or the first part of their small bowel. They're checking if it can make visible signs of the disease disappear.
Poland - active not recruitingPHASE2
A Study of Combination Therapy With Guselkumab and Golimumab in Participants With Moderately to Severely Active Crohn's Disease
This study is looking at a new combination treatment, JNJ-78934804, for people aged 18-65 with Crohn's disease that is moderate to severe. It compares this new treatment to existing medicines, guselkumab and golimumab, to see how well it works over 48 weeks.
United States · Australia · Austria - recruitingPHASE3
A Study to Evaluate the Efficacy and Safety of Tulisokibart (MK-7240) in Participants With Moderate to Severe Crohn's Disease (MK-7240-008)
This study is testing a new medication called Tulisokibart for people with moderate to severe Crohn's disease. Researchers want to see if it's safe and effective in reducing symptoms and improving the gut lining. It involves different ways of giving the medicine compared to a dummy treatment.
United States · Australia · Austria - active not recruitingPHASE3
A Study of the Efficacy and Safety of Risankizumab in Participants With Crohn's Disease
This study looks at a new medicine called risankizumab for Crohn's disease. We're checking how well it works and if it's safe for people who have already started treatment. It's like a follow-up to see how different doses work and how people feel over time.
United States · Argentina · Australia - recruitingPHASE3
An Induction Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Crohn's Disease
This study is testing a new medicine called Duvakitug for people with Crohn's disease that isn't well controlled. It compares Duvakitug to a dummy medicine to see if it's safe and effective in improving symptoms for those with moderately to severely active Crohn's.
United States · Argentina · Australia - recruitingPHASE3
A Study of Vedolizumab With and Without Upadacitinib in Adults With Crohn's Disease
This study looks at combining two medicines, vedolizumab and upadacitinib, for adults with moderate to severe Crohn's Disease. It aims to see if this combination better reduces bowel inflammation and ulcers compared to vedolizumab alone, and to check its safety.
United States · Austria · Belgium - active not recruitingPHASE2, PHASE3
A Study of the Efficacy and Safety of Guselkumab in Participants With Moderately to Severely Active Crohn's Disease
This study looks at a new medicine called guselkumab for adults with moderately to severely active Crohn's disease. Researchers want to see how well it works and if it's safe compared to other treatments or a dummy medicine.
United States · Australia · Austria - recruitingPHASE3
A Study to Assess Adverse Events, Change in Disease Activity, and How Intravenous and Subcutaneous Risankizumab Moves Through the Body of Pediatric Participants With Moderately to Severely Active Crohn's Disease
This study is looking at a new treatment called risankizumab for children and young people aged 2 to 17 with Crohn's disease that hasn't responded well to other medicines. Scientists want to see if it's safe, helps their symptoms, and how it works in their bodies.
United States · Belgium · Bulgaria - completed
PROFILE - personalised medicine in Crohn's disease
The PROFILE study looks at whether a simple blood test can help doctors choose the right treatment for people newly diagnosed with Crohn’s disease. Everyone in the trial receives proven, active treatments. The goal is to see if matching treatment to a person's biology reduces painful flare-ups.
United Kingdom · England · Scotland - completedPhase I/II
Treg Immunotherapy in Crohn’s Disease
The TRIBUTE study tests a new treatment for adults with moderate to severe Crohn’s disease. Researchers take a patient's own calming immune cells, grow more of them in a laboratory, and return them via a drip. The main goal is to find out if this treatment is safe and reduces gut swelling.
United Kingdom · England - recruitingHuman Pharmacology (Phase I)- First administration to humans
A Phase 1 Study to Evaluate the Safety and Target Engagement of EXL01 in the Maintenance of Steroid-induced Clinical Response or Remission in Patients with Mild to Moderate Crohn's Disease
This early-stage study is looking at a new medicine called EXL01 for people with mild to moderate Crohn's disease. It aims to see if EXL01 is safe and works to keep people feeling well after they've improved with steroid treatment.
Belgium · Poland - not yet recruitingPhase II
A study to investigate whether novel therapeutic vaccines can improve Crohn's disease by targeting a bacterium thought to contribute to the condition
This study is testing two new vaccines for Crohn's disease. Researchers believe these vaccines could help by targeting a specific common bacterium. It's a Phase II trial looking at how well they work, their safety, and how the body reacts in adults with active Crohn's.
United Kingdom · England - recruitingTherapeutic exploratory (Phase II)
A phase II, national, multicenter, uncontrolled and open trial to evaluate the feasibility and safety of lamparoscopic administration of allogenic mesenchymals stem cell (adMSC) extracted by lipoaspirate from healthy patients, for the treatment of patients with inflammatory bowel strictures associated with Crohn's disease. SM
This study looks into using special cells from healthy donors to treat a problem called strictures in people with Crohn's disease. Doctors want to see if this treatment is safe and how well it works to reduce blockages in the gut.
Spain - recruitingTherapeutic exploratory (Phase II)
A phase IIa, open label, Single-centre study to assess the initial antifibrotic efficacy, safety, tolerability, pharmacokinetic and pharmacodynamic profile of MBF-118 in Crohn’s disease patients with stenosis.
This study is testing a new medicine, MBF-118, for people with Crohn's disease whose gut has narrowed (stenosis). Researchers want to see if it's safe and if it helps reduce the narrowing and inflammation, over about two months.
Spain - recruitingHuman Pharmacology (Phase I)- Other
PET study of changes in [11C]AZ14132516 uptake following administration of AZD7798 to healthy participants and patients with Crohn’s disease
This study is looking at a new medicine for Crohn's disease. We want to see how a special scan changes before and after taking the medicine, both in healthy people and those with Crohn's. This helps us understand how the medicine works.
Sweden - recruitingHuman Pharmacology (Phase I)- First administration to humans
A Phase 0 Open Label Positron Emission Tomography Study to Assess the Biodistribution and Binding Characteristics of [11C]AZ14132516 Following Administration to Healthy Participants
This early-stage study uses special scans to see how a new experimental substance called [11C]AZ14132516 moves and attaches in the body of healthy volunteers. It helps scientists understand if it could eventually be used to study Crohn's disease.
Sweden - recruitingPHASE2
A Study to Investigate Efficacy and Safety of Brivekimig in Participants With Crohn's Disease
This study is testing a new medicine, SAR442970, for people with moderate to severe Crohn's disease. Researchers want to see if it's safe and helps improve symptoms compared to a dummy pill. It's a key step in developing new treatments.
United States · Australia · Belgium - active not recruitingPHASE3
Crohn's Disease: Efficacy, Safety, and Pharmacokinetics of Upadacitinib in Pediatric Subjects With Moderately to Severely Active Crohn's Disease
This study is testing a new medicine called Upadacitinib for children and teenagers with Crohn's disease. It's for those whose current treatments aren't working well. We want to see if it's safe and helps them feel better.
United States · Australia · Belgium - active not recruitingPHASE3
A Maintenance and Long-Term Extension Study of the Efficacy and Safety of Upadacitinib (ABT-494) in Participants With Crohn's Disease Who Completed the Studies M14-431 or M14-433
This study looks at a new medicine called upadacitinib for adults with Crohn's disease. It checks how well it works and if it's safe over a long time for people who have already started treatment in previous studies. The aim is to see if it can help manage Crohn's.
United States · Argentina · Australia - active not recruitingPHASE3
A Long-term Extension Study of Mirikizumab (LY3074828) in Participants With Crohn's Disease
This study is looking into the long-term effects and safety of a medicine called mirikizumab for people with Crohn's disease. Participants have already taken part in a related study, and this new study will help us understand how the medicine works over a longer period.
United States · Argentina · Australia - active not recruiting
A Non-Interventional Clinical Study to Evaluate Long-Term Safety and Effectiveness of HUMIRA (Adalimumab) in Pediatric Patients With Moderately to Severely Active Crohn's Disease (CD)
This study looks at how well a medicine called Humira works and how safe it is for children aged 6 to 17 with Crohn's disease. It also compares Humira to other common treatments like azathioprine, 6-mercaptopurine, or methotrexate, watching patients over a long time.
United States · Bosnia and Herzegovina · Bulgaria - recruitingPHASE2
Study of Targeted Therapies for the Treatment of Adult Participants With Moderate to Severe Crohn's Disease
This study looks at new medications for adults with moderate to severe Crohn's disease. Researchers want to see how well these 'targeted therapies' work and if they cause side effects, to find better ways to manage the condition.
United States · Austria · Belgium - recruiting
Pregnancy and Inflammatory Bowel Disease
This study looks at how inflammatory bowel disease (IBD) affects pregnancy and how pregnancy affects IBD. We're studying women with Crohn's disease or ulcerative colitis who have been pregnant, aiming to understand symptoms during pregnancy and after birth.
France - recruitingPHASE2
A Study on the Safety of TAK-279 and Whether it Can Reduce Inflammation in the Bowel of Participants With Moderately to Severely Active Crohn's Disease
This study looks at a new drug, TAK-279, for people aged 18-75 with Crohn's disease that isn't well-controlled. We want to see if it reduces gut inflammation and is safe, compared to a dummy drug. It lasts about one year.
United States · Australia · Belgium - recruiting
MRE Predictors of Disease Relapse After Stopping Biologics
This study looks at whether a special MRI scan, called MRE, can help predict if Crohn's disease will come back quickly after people stop taking certain medications (biologics). It aims to help doctors decide who can safely stop these treatments.
United Kingdom - recruitingPHASE4
A Study of Vedolizumab Intravenous (IV) and Adalimumab or Vedolizumab and Ustekinumab in Adults With Crohn's Disease
This study looks at new ways to treat Crohn's disease. Researchers are testing if combining two medicines, vedolizumab and either adalimumab or ustekinumab, works better than vedolizumab alone for adults with moderate to severe Crohn's.
United States · Canada - authorisedTherapeutic use (Phase IV)
OPTIMAL CARE WITH GUSELKUMAB IN CROHN’S DISEASE
This study looks at how well a medicine called guselkumab works for people with Crohn's disease. Researchers want to see if it can help people stay well without steroids and reduce a marker of gut inflammation over 48 weeks.
France - recruiting
A Study to Generate Real-world Evidence of Guselkumab Effectiveness in Inflammatory Bowel Disease in Germany
This study looks at how a medicine called guselkumab works for people in Germany with Crohn's disease or ulcerative colitis in real life. It also checks how this medicine affects their quality of life, tiredness, and daily activities.
Germany - active not recruitingPHASE3
Transmural Healing and Disease-Modifying Effect of Guselkumab in Crohn's Disease Patients
This study looks at how a medicine called guselkumab helps people with Crohn's disease. Researchers want to see if it heals all layers of the gut and how well it works overall, using special scans to check progress.
United States · Australia · Belgium - recruiting
Longitudinal Study on Bacterial Production of LPC and LPA in Patients With Inflammatory Bowel Disease
This study looks at whether gut bacteria in people with Crohn's and ulcerative colitis cause ongoing tummy pain, even when their condition is calm. They want to find out if certain fats produced by these bacteria, called LPC and LPA, are the culprits.
Canada - recruiting
A Retrospective Study to Evaluate Treat-to-Target and Disease Modification in Adult Participants With Crohn's Disease and Ulcerative Colitis in Real World Setting
This study looks back at medical records of adults in the UK with Crohn's disease or ulcerative colitis. It aims to see how well a 'treat-to-target' approach helps manage these conditions and if it leads to better long-term health outcomes for patients.
China · France - recruitingPHASE3
A Study of Mirikizumab (LY3074828) in Pediatric Participants With Crohn's Disease
This study is looking at a new medicine called mirikizumab for children and teenagers with Crohn's disease. It wants to find out if it's safe, works well, and how the body handles it. It will involve those who haven't responded well to other treatments.
United States · Austria · Belgium - recruitingPHASE3
Mirikizumab and Tirzepatide Administered in Adult Participants With Moderately to Severely Active Crohn's Disease and Obesity or Overweight
This study looks at new medicines, mirikizumab and tirzepatide, for adults with Crohn's disease who are also overweight or have obesity. It wants to see if these treatments are safe and if they help manage Crohn's symptoms and potentially aid weight management.
United States · Austria · Belgium - recruitingPHASE2
A Study to Investigate Efficacy and Safety of SAR441566 in Patients With Crohn's Disease.
This study is testing a new medicine called SAR441566 for adults with Crohn's disease. Researchers want to see if it helps reduce symptoms and if it's safe. Some people will get the medicine, others a dummy pill, to compare.
United States · Argentina · Australia - recruiting
VOICE-Early Response to Vedolizumab and IL-23 Antagonists in Participants With Crohn's Disease: A Prospective Observational Study
This study looks at how quickly different treatments for Crohn's disease, like vedolizumab and others, start working. We want to understand if vedolizumab actually takes longer to reduce symptoms than other medicines, using patient feedback as key information.
United States · Canada - recruitingNA
Study of the Kono-S Anastomosis Versus the Side-to-side Functional End Anastomosis
This study compares two surgical methods, Kono-S and side-to-side, for treating Crohn's disease in the gut. The aim is to see which method is better at preventing the disease from coming back after surgery and improving long-term health for patients.
United States · Belgium · Finland - recruitingPHASE2
A Phase 2 Study to Evaluate MORF-057 in Adults With Moderately to Severely Active Crohn's Disease
This study is testing a new medicine called MORF-057 for adults with moderate to severe Crohn's disease. It compares different doses of the medicine to a dummy pill to see if it's safe and helps improve symptoms.
United States · Australia · Austria - recruitingNA
Vibration Exercise for Crohn's to Observe Response
This study looks at whether a special type of exercise, called whole body vibration, can help people with Crohn's disease feel better. We want to see if standing on a vibrating plate for a short time can improve quality of life and reduce symptoms like tiredness.
United Kingdom - recruitingPHASE3
A Master Protocol (AMAZ): A Study of Mirikizumab (LY3074828) in Pediatric Participants With Ulcerative Colitis or Crohn's Disease (SHINE-ON)
This study looks at a medicine called Mirikizumab for children and teenagers aged 2 to 19 with Ulcerative Colitis or Crohn's Disease. It checks how well the medicine works over a long time to help manage these conditions.
United States · Austria · Belgium - recruitingPHASE3
A Study of Vedolizumab in Children With Ulcerative Colitis (UC) or Crohn's Disease (CD)
This study looks at the long-term safety of a medicine called vedolizumab for children and young people with Crohn's disease or ulcerative colitis. It's for those who have already taken part in a previous study with vedolizumab.
United States · Australia · Belgium - active not recruitingPHASE2
Study Evaluating AZD7798 for Treatment in Crohn's Disease Patients With an Ileostomy
This study is investigating a new medication called AZD7798 for people with Crohn's disease who have had an ileostomy. We want to see if it's safe, well-tolerated, and helps heal the gut lining compared to a dummy drug.
Belgium · Italy · Netherlands - authorisedTherapeutic use (Phase IV)
Methotrexate in paediatric and adolescent Crohn’s disease: an observational study
This study looks at how well a medicine called methotrexate works for young people with Crohn's disease over a year. It checks how much of the medicine stays in the body and if patients need to stop using it due to side effects or if it's not helping enough.
Netherlands