Diabetes mellitus type 1 research hub

A study to test how insulin NNC0471-0119 H works in the body in participants with type 1 diabetes when given by an insulin pump.

This study is looking at a new type of insulin, called NNC0471-0119 H, for people with type 1 diabetes. Researchers want to understand how it works in the body when delivered using an insulin pump. It's an early-stage study to learn more about this new treatment.

Supplementation With B. Infantis for Mitigation of Type 1 Diabetes Autoimmunity

This study looks at whether giving a special good bacteria (B. infantis) to very young babies at higher risk of type 1 diabetes can help prevent their immune system from attacking their own body, which is what causes the condition.

TrialNet Pathway to Prevention of T1D

This study helps us understand how type 1 diabetes develops by screening relatives of people with the condition. We look for early signs in the blood. If detected, we offer close monitoring and a chance to join studies working on prevention or early treatment.

Anti-viral Action Against Type 1 Diabetes Autoimmunity

This study is testing if a COVID-19 vaccine can help prevent type 1 diabetes in young children who are at a higher risk. It involves giving children, aged 6 months and older, either the vaccine or a dummy shot to see if it reduces their chance of developing certain signs of diabetes.

A Study of Baricitinib (LY3009104) for the Delay of Stage 3 Type 1 Diabetes in At-Risk Children and Adults

This study is looking into whether a medicine called baricitinib can delay Type 1 Diabetes in children and adults who are at a high risk of developing it. It's a key step in preventing the condition.

RT-CGM in Young Adults at Risk of DKA

This study looks at how a special device called real-time continuous glucose monitoring (RT-CGM) helps young adults, aged 18-25, manage their type 1 diabetes. We want to see if it improves blood sugar control and reduces hospital visits for high blood sugar.

Prevention of Chronic Kidney Disease(CDK) Progression in Type 1 Diabetes With Long Term Use of Sodium-Glucose-coTransporter Inhibitors Avoiding Kidney hypOxia

This study looks at a new drug, sotagliflozin, to see if it can protect kidneys in people with type 1 diabetes. Researchers want to understand how it affects kidney oxygen levels and overall kidney health over 12 weeks.

Closed Loop and Education for Hypoglycemia Awareness Restoration

This study looks at new ways to help people with type 1 diabetes better recognise when their blood sugar is going too low. It tests special insulin pumps and educational programmes to see which ones work best to improve awareness and reduce dangerous low blood sugar episodes.

A Safety, Tolerability, and Efficacy Study of VX-880 in Participants With Type 1 Diabetes

This study looks at a new treatment called VX-880 for people with Type 1 diabetes. We want to see if it's safe, if people can tolerate it well, and if it helps those who often have severe low blood sugar and don't realise it.

Quantifying Artificial Pancreas-related Changes in Diabetic Neuropathy

This study looks at how new insulin delivery systems, like insulin pumps and 'artificial pancreases', might help people with type 1 diabetes who have nerve damage (neuropathy) by improving blood sugar control. It compares them to standard insulin injections.

A Study of Baricitinib (LY3009104) to Preserve Beta Cell Function in Children and Adults Newly Diagnosed With Type 1 Diabetes (BARICADE-PRESERVE)

This study investigates if a drug called baricitinib can protect the body's insulin-making cells in children and adults newly diagnosed with type 1 diabetes. It aims to see if preserving these cells helps manage the condition better.

Recent-Onset Type 1 Diabetes Extension Study Evaluating the Long-Term Safety of Teplizumab (PROTECT Extension)

This study looks at the long-term safety of a treatment called teplizumab for young people with recent Type 1 diabetes. It follows participants from a previous study, PROTECT, for an extra 42 months to see how they're doing without giving new medication.

Chronotype of Patients With Diabetes and Effect on Glycaemic Control

This study looks at how your natural sleep patterns, called chronotype, are linked to managing diabetes and your overall heart health. We want to understand how different sleep timings affect blood sugar levels and other health factors in people with type 1 and type 2 diabetes.

Glucagon enhanced insulin absorption in Diabetes Mellitus type 1